Results 51 to 60 of about 64,872 (306)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Unfamiliar habits: James and the ethics and politics of self-experimentation [PDF]

, 2015
The article critically surveys William James's understanding of habit in the light of his wider ethical and political concerns, showcasing its import for a contemporary philosophical usage of the ...
Marchetti, Sarin
core  

Physical Study by Surface Characterizations of Sarin Sensor on the Basis of Chemically Functionalized Silicon Nanoribbon Field Effect Transistor

, 2016
Surface characterizations of an organophosphorus (OP) gas detector based on chemically functionalized silicon nanoribbon field-effect transistor (SiNR-FET) were performed by Kelvin Probe Force Microscopy (KPFM) and ToF-SIMS, and correlated with changes ...
Carella, A., Dubois, E., Guerin, D., Lenfant, S., Melin, T., Ordronneau, L., Passi, V., Simonato, J. P., Smaali, K., Vuillaume, D.   +9 more
core   +4 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Creating realistic nerve agent victim profiles for computer simulation of medical CBRN disaster response

Frontiers in Public Health, 2023
In the last decades, Chemical, Biological, Radiological and Nuclear (CBRN) threats have become serious risks prompting countries to prioritize preparedness for such incidents.
Ruben De Rouck, Mehdi Benhassine, Michel Debacker, Christian Dugauquier, Christian Dugauquier, Erwin Dhondt, Filip Van Utterbeeck, Ives Hubloue   +7 more
doaj   +1 more source

Jamesian Liberalism and the Self [PDF]

, 2019
Despite he did not write any full-fledge and comprehensive treatise of the kind Thomas Jefferson, Walter Lippman, or John Rawls did, William James is among the great American liberal philosophers.
MARCHETTI, SARIN
core  

Central Executive Dysfunction and Deferred Prefrontal Processing in Veterans with Gulf War Illness. [PDF]

, 2013
Gulf War Illness is associated with toxic exposure to cholinergic disruptive chemicals. The cholinergic system has been shown to mediate the central executive of working memory (WM).
Bennett, Ilana J, Brigante, Ryan M, Haley, Robert W, Hubbard, Nicholas A, Hutchison, Joanna L, Motes, Michael A, Rypma, Bart, Shokri-Kojori, Ehsan   +7 more
core   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Antidote administration in mice exposed to sarin resulted in brainwave stabilization without cognitive protection

Neuroscience Research
Resurgence of sarin use in the Syrian conflict demonstrates that chemical weapons are a vivid threat. Like other organophosphate compounds, sarin inhibits acetylcholinesterase resulting in cholinergic crisis.
Mélanie Lagadec, Pauline Thiebot, Isabelle Malissin, Alexandre Champault, Julie Somkhit, Julie Knoertzer, Assia Belkebir, Bruno Megarbane, Karine Thibault, Gregory Dal Bo   +9 more
doaj   +1 more source

OXIMES AND ATROPINE IN SARIN POISONING [PDF]

British Journal of Pharmacology and Chemotherapy, 1957
Three oximes, monoisonitrosoacetone (MINA), pyridine‐2‐aldoxime methiodide (PAM) and diacetylmonoxime (DAM), have been examined in combination with atropine as antidotes in sarin poisoning. When treatment was administered 15 min. before sarin, atropine enhanced the protective effect of MINA and DAM 2 to 3 times and of PAM 9 to 10 times in mice and rats.
openaire   +2 more sources