Results 41 to 50 of about 90,927 (310)

High intensity training may reverse the fiber type specific decline in myogenic stem cells in multiple sclerosis patients

Frontiers in Physiology, 2016
Multiple sclerosis (MS) is associated with loss of skeletal muscle mass and function. The myogenic stem cells (satellite cells – SCs) are instrumental to accretion of myonuclei, but remain to be investigated in MS.
Jean eFarup, Jean eFarup, Ulrik eDalgas, Charly eKeytsman, Bert O. Eijnde, Inez eWens   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes [PDF]

, 2010
Copyright: © 2010 Stimpson et al.Genome rearrangement often produces chromosomes with two centromeres (dicentrics) that are inherently unstable because of bridge formation and breakage during cell division. However, mammalian dicentrics, and particularly
Sullivan, Beth A., Sullivan, Beth A, Karen E. Hayden, Kaitlin M. Stimpson, Beth A Sullivan, Bridger Joanna M., Song, IY, Sullivan, BA, Ihn Young Song, Beth A. Sullivan, Karen E Hayden, Hayden, Karen E., Jauch, A, Bridger, Joanna M., Joanna M Bridger, Joanna M. Bridger, Hayden, Karen E, Song Ihn Young, Jauch, Anna, Holtgreve-Grez, Heidi, Heidi Holtgreve-Grez, Holtgreve-Grez Heidi, Stimpson, Kaitlin M, Stimpson, KM, Kaitlin M Stimpson, Anna Jauch, Bridger, JM, Jauch Anna, Bridger, Joanna M, Stimpson Kaitlin M., Sullivan Beth A., Song, Ihn Young, Hayden Karen E., Hayden, KE, Holtgreve-Grez, H, Stimpson, Kaitlin M.   +35 more
core   +1 more source

Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle

eLife, 2019
In overloaded and regenerating muscle, the generation of new myonuclei depends on muscle satellite cells (MuSCs). Because MuSC behaviors in these two environments have not been considered separately, MuSC behaviors in overloaded muscle remain unexamined.
Sumiaki Fukuda, Akihiro Kaneshige, Takayuki Kaji, Yu-taro Noguchi, Yusei Takemoto, Lidan Zhang, Kazutake Tsujikawa, Hiroki Kokubo, Akiyoshi Uezumi, Kazumitsu Maehara, Akihito Harada, Yasuyuki Ohkawa, So-ichiro Fukada   +12 more
doaj   +1 more source

Bu-M-P-ing Iron: How BMP Signaling Regulates Muscle Growth and Regeneration

Journal of Developmental Biology, 2020
The bone morphogenetic protein (BMP) pathway is best known for its role in promoting bone formation, however it has been shown to play important roles in both development and regeneration of many different tissues.
Matthew J Borok, Despoina Mademtzoglou, Frederic Relaix   +2 more
doaj   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

No change in skeletal muscle satellite cells in young and aging rat soleus muscle

, 2009
Satellite cells are muscle stem cells capable of replenishing or increasing myonuclear number. It is postulated that a reduction in satellite cells may contribute to age-related sarcopenia.
Brooks, Naomi, Schuenke, Mark, Hikida, Robert   +2 more
core   +1 more source

Noninvasive PET Imaging and Tracking of Engineered Human Muscle Precursor Cells for Skeletal Muscle Tissue Engineering [PDF]

, 2016
Transplantation of human muscle precursor cells (hMPCs) is envisioned for the treatment of various muscle diseases. However, a feasible noninvasive tool to monitor cell survival, migration, and integration into the host tissue is still missing. METHODS:
Handschin, Christoph, Eberli, Daniel, Ametamey, Simon M, Dinulovic, Ivana, Salemi, Souzan, Meline Stoelting, Deana Haralampieva, Ivana Dinulovic, Tullio Sulser, Haralampieva, Deana, Krämer, Stefanie D., Sulser, Tullio, Stefanie D. Krämer, Christoph Handschin, Daniel Eberli, Thomas Betzel, Simon M. Ametamey, Stoelting, Meline, Betzel, Thomas, Souzan Salemi, Schibli, Roger, Ametamey, Simon M., Roger Schibli, Krämer, Stefanie D; https://orcid.org/   +23 more
core   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Microcarriers for Upscaling Cultured Meat Production

Frontiers in Nutrition, 2020
Due to the considerable environmental impact and the controversial animal welfare associated with industrial meat production, combined with the ever-increasing global population and demand for meat products, sustainable production alternatives are ...
Vincent Bodiou, Vincent Bodiou, Vincent Bodiou, Panagiota Moutsatsou, Panagiota Moutsatsou, Mark J. Post, Mark J. Post, Mark J. Post   +7 more
doaj   +1 more source