Results 21 to 30 of about 80,080 (219)

Emerging gene editing strategies for Duchenne muscular dystrophy targeting stem cells

Frontiers in Physiology, 2014
The progressive loss of muscle mass characteristic of many muscular dystrophies impairs the efficacy of most of the gene and molecular therapies currently being pursued for the treatment of those disorders.
Carmen eBertoni
doaj   +1 more source

Sphingosine 1-phosphate axis: a new leader actor in skeletal muscle biology

Frontiers in Physiology, 2013
Sphingosine 1-phosphate (S1P) is a bioactive lipid involved in the regulation of biological processes such as proliferation, differentiation, motility and survival. Here we review the role of S1P in the biology and homeostasis of skeletal muscle.
Chiara eDonati, Chiara eDonati, Francesca eCencetti, Francesca eCencetti, Paola eBruni, Paola eBruni   +5 more
doaj   +1 more source

Advances in vascular endothelial cell-mediated regulation of satellite cell repair and regeneration

Inflammation and Regeneration
With advancing age, vascular endothelial cells (ECs) exhibit functional decline and reduced angiogenic capacity, adversely affecting muscle homeostasis.
Chunyan Yang, Liting Zhang, Lihua Liu, Lijuan Bai, Yun Liu, Ruiyun Wang, Benling Qi   +6 more
doaj   +1 more source

Muscle stem cells contribute to long‐term tissue repletion following surgical sepsis

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background Over the past decade, advances in sepsis identification and management have resulted in decreased sepsis mortality. This increase in survivorship has highlighted a new clinical obstacle: chronic critical illness (CCI), for which there are no ...
Rebecca E. Schmitt, Aneesha Dasgupta, Paige C. Arneson‐Wissink, Srijani Datta, Alexandra M. Ducharme, Jason D. Doles   +5 more
doaj   +1 more source

Impact of Metastatic Patterns on Survival and Response to Therapy in Neuroblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background While the presence of metastases in neuroblastoma (NB) is a well‐established prognostic factor, the clinical significance of dissemination patterns and tumour burden and their impact on response and survival remains poorly understood.
Mariona Morell‐Daniel, Santiago Pérez‐Hoyos, Aroa Soriano, Ana Coma, Amalia Varo, Raquel Hladun, Gabriela Guillén, Soraya Mico, Marta Garrido, Lourdes Rubio, Alba Rubio‐San‐Simón, Ana Minguez, Ricardo López‐Almaraz, Laura Illade, Miguel F. Segura, Lucas Moreno   +15 more
wiley   +1 more source

Histological analysis of the medial gastrocnemius muscle in young healthy children

Frontiers in Physiology
IntroductionHistological data on muscle fiber size and proportion in (very) young typically developing (TD) children is not well documented and data on capillarization and satellite cell content are also lacking.AimsThis study investigated the ...
Anke Andries, Jorieke Deschrevel, Karen Maes, Nathalie De Beukelaer, Marlies Corvelyn, Lauraine Staut, Hannah De Houwer, Domiziana Costamagna, Domiziana Costamagna, Domiziana Costamagna, Stefaan Nijs, Willem-Jan Metsemakers, Elga Nijs, Greet Hens, Eva De Wachter, Sandra Prinsen, Kaat Desloovere, Anja Van Campenhout, Ghislaine Gayan-Ramirez   +18 more
doaj   +1 more source

High intensity training may reverse the fiber type specific decline in myogenic stem cells in multiple sclerosis patients

Frontiers in Physiology, 2016
Multiple sclerosis (MS) is associated with loss of skeletal muscle mass and function. The myogenic stem cells (satellite cells – SCs) are instrumental to accretion of myonuclei, but remain to be investigated in MS.
Jean eFarup, Jean eFarup, Ulrik eDalgas, Charly eKeytsman, Bert O. Eijnde, Inez eWens   +5 more
doaj   +1 more source

The Role of Satellite Cells in Skeletal Muscle Regeneration—The Effect of Exercise and Age

Biology, 2021
The population of satellite cells (mSCs) is highly diversified. The cells comprising it differ in their ability to regenerate their own population and differentiate, as well as in the properties they exhibit.
Agnieszka Kaczmarek, Mateusz Kaczmarek, Maria Ciałowicz, Filipe Manuel Clemente, Paweł Wolański, Georgian Badicu, Eugenia Murawska-Ciałowicz   +6 more
doaj   +1 more source

The Role of Chemotherapy in Pediatric Myoepithelial Carcinoma: A Systematic Review of the Literature

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Myoepithelial carcinoma (MEC) in pediatric patients is a rare and aggressive malignancy characterized by heterogeneous morphology and variable molecular features. The optimal role of chemotherapy remains unclear. We conducted a systematic review according to PRISMA 2020 guidelines to evaluate chemotherapy in pediatric and young‐adult patients ...
Marco Salvi, Maria Carmen Affinita, Giulia Fichera, Luisa Santoro, Angela Scagnellato, Calogero Virgone, Elena Poli, Gianni Bisogno   +7 more
wiley   +1 more source

Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle

eLife, 2019
In overloaded and regenerating muscle, the generation of new myonuclei depends on muscle satellite cells (MuSCs). Because MuSC behaviors in these two environments have not been considered separately, MuSC behaviors in overloaded muscle remain unexamined.
Sumiaki Fukuda, Akihiro Kaneshige, Takayuki Kaji, Yu-taro Noguchi, Yusei Takemoto, Lidan Zhang, Kazutake Tsujikawa, Hiroki Kokubo, Akiyoshi Uezumi, Kazumitsu Maehara, Akihito Harada, Yasuyuki Ohkawa, So-ichiro Fukada   +12 more
doaj   +1 more source