Results 1 to 10 of about 4,549 (160)

Interplay between microtubule interactome, myonuclei mechanotransduction, and positioning in myopathies [PDF]

Nucleus
Myofibers are the building block of skeletal muscle cells providing its capacity to contract and produce movement. The microtubule (MT) network sustains myofiber formation and its spatial organization is remodel during myofiber formation.
Streichenberger Nathalie, Vincent Gache   +1 more
exaly   +6 more sources

Going nuclear: Molecular adaptations to exercise mediated by myonuclei

Sports Medicine and Health Science, 2023
Muscle fibers are multinucleated, and muscle fiber nuclei (myonuclei) are believed to be post-mitotic and are typically situated near the periphery of the myofiber.
Kevin Zwetsloot, Kevin Murach, Pieter Koopmans   +2 more
exaly   +6 more sources

Specialized Positioning of Myonuclei Near Cell-Cell Junctions [PDF]

Frontiers in Physiology, 2018
Skeletal muscles are large cells with multiple nuclei that are precisely positioned. The importance of the correct nuclear position is highlighted by the correlation between mispositioned nuclei and muscle disease (Spiro et al., 1966; Gueneau et al ...
Margherita Perillo, Eric S Folker, Folker Eric S   +2 more
exaly   +5 more sources

Maintenance of subsynaptic myonuclei number is not driven by neural input

Frontiers in Physiology, 2023
The development and maintenance of neuromuscular junctions (NMJ) are supported by a specialized population of myonuclei that are referred to as the subsynaptic myonuclei (SSM).
Lloyd P. Ruiz, Peter C. Macpherson, Susan V. Brooks, Susan V. Brooks   +3 more
doaj   +3 more sources

Detection of muscle stem cell-derived myonuclei in murine overloaded muscles

STAR Protocols, 2022
Summary: Muscle satellite cells (MuSCs) supply nuclei to existing myofibers in response to mechanical loading. This myonuclear accretion is critical for efficient muscle hypertrophy.
Akihiro Kaneshige, Takayuki Kaji, Hayato Saito, Tatsuyoshi Higashimoto, Ayasa Nakamura, Tamaki Kurosawa, Madoka Ikemoto-Uezumi, Akiyoshi Uezumi, So-ichiro Fukada   +8 more
doaj   +3 more sources

MACF1 controls skeletal muscle function through the microtubule-dependent localization of extra-synaptic myonuclei and mitochondria biogenesis

eLife, 2021
Skeletal muscles are composed of hundreds of multinucleated muscle fibers (myofibers) whose myonuclei are regularly positioned all along the myofiber’s periphery except the few ones clustered underneath the neuromuscular junction (NMJ) at the synaptic ...
Alireza Ghasemizadeh, Emilie Christin, Alexandre Guiraud, Nathalie Couturier, Marie Abitbol, Valerie Risson, Emmanuelle Girard, Christophe Jagla, Cedric Soler, Lilia Laddada, Colline Sanchez, Francisco-Ignacio Jaque-Fernandez, Vincent Jacquemond, Jean-Luc Thomas, Marine Lanfranchi, Julien Courchet, Julien Gondin, Laurent Schaeffer, Vincent Gache   +18 more
doaj   +1 more source

Skeletal Muscle Nuclei in Mice are not Post-mitotic

Function, 2023
The skeletal muscle research field generally accepts that nuclei in skeletal muscle fibers (ie, myonuclei) are post-mitotic and unable to proliferate. Because our deuterium oxide (D2O) labeling studies showed DNA synthesis in skeletal muscle tissue, we ...
Agnieszka K Borowik, Arik Davidyan, Frederick F Peelor, Evelina Voloviceva, Stephen M Doidge, Matthew P Bubak, Christopher B Mobley, John J McCarthy, Esther E Dupont-Versteegden, Benjamin F Miller   +9 more
doaj   +1 more source

Positional Context of Myonuclear Transcription During Injury-Induced Muscle Regeneration

Frontiers in Physiology, 2022
Fundamental aspects underlying downstream processes of skeletal muscle regeneration, such as myonuclear positioning and transcription are poorly understood.
Kole H. Buckley, Andrea L. Nestor-Kalinoski, Francis X. Pizza   +2 more
doaj   +1 more source

Morphometric and Histological Pattern of Recovery of Adult Rat Gastrocnemius Muscle Exposed to 8-Week Anabolic Steroid Administration and Similar Period of Drug Stoppage [PDF]

The Egyptian Journal of Histology, 2023
Introduction: Anabolic androgenic steroids (AAS) were first used by athletes involved in pursuits of strength, young men interested in enhancing their appearance.
Adel Abdelmalek, Doaa Hamed, tarik mostafa, Rasha Anwar   +3 more
doaj   +1 more source

Syd/JIP3 and JNK signaling are required for myonuclear positioning and muscle function. [PDF]

PLoS Genetics, 2014
Highlighting the importance of proper intracellular organization, many muscle diseases are characterized by mispositioned myonuclei. Proper positioning of myonuclei is dependent upon the microtubule motor proteins, Kinesin-1 and cytoplasmic Dynein, and ...
Victoria K Schulman, Eric S Folker, Jonathan N Rosen, Mary K Baylies   +3 more
doaj   +1 more source