Results 11 to 20 of about 4,549 (160)

Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle [PDF]

Skeletal Muscle
Non-peripheral (displaced) myonuclei are characteristic of skeletal muscle pathology and severe injury but also appear after exercise and with aging. Displaced myonuclei are typically attributed to the activity of muscle stem cells, or satellite cells ...
Nathan Serrano, Pieter Jan Koopmans, Kevin A. Murach   +2 more
doaj   +2 more sources

Skeletal muscle memory: implications for sports, aging and nutrition [PDF]

Frontiers in Nutrition
Observations of an enhanced hypertrophic response in previously trained muscles following periods of detraining have led researchers to propose that muscle tissue retains a form of “cellular memory”, even after returning to baseline muscle mass.
Íñigo M. Pérez-Castillo, Sergio R. Ruiz-Caride, Ricardo Rueda, José López-Chicharro, Felipe Segura-Ortiz, Hakim Bouzamondo   +5 more
doaj   +2 more sources

Single‐Nucleus Transcriptome Reveals Cellular Heterogeneity and Transcriptional Response to Heat Stress in Skeletal Muscle [PDF]

Journal of Cachexia, Sarcopenia and Muscle
Background Heat stress can induce skeletal muscle injury. Typical characteristics of heat‐exposed muscle tissues include apoptosis, oxidative stress and autophagy.
Ziyin Han, Li Chen, Zhiyu Lei, Jiaman Zhang, Ziyu Chen, Xiaolan Fan, Bo Zeng, Anan Jiang, Hai Xiang, Hua Li, Mingzhou Li, Long Jin   +11 more
doaj   +2 more sources

A muscular dystrophy associated with bi‐allelic LEMD2 variants: Expanding the genotype of nuclear envelopathies [PDF]

Brain Pathology, Volume 36, Issue 4, July 2026.
Proteomics‐guided exome re‐analysis identifies bi‐allelic variants in the nuclear envelope LEMD2 gene, expanding its phenotypic spectrum. Created in BioRender. Pauper, M. (2026) https://BioRender.com/xamvo92.
Marc Pauper, Heike Kölbel, Iakowos Karakesisoglou, Anne Schänzer, Johann Böhm, Rachel Thompson, Nicolai Kohlschmidt, Bernd Ringel, Gisèle Bonne, Katja Neuhoff, Andrea Gangfuß, Ozge Aksel Kilicarslan, Sergi Beltran Agullo, Andreas Hentschel, Ulrike Schara‐Schmidt, Hanns Lochmüller, Kiran Polavarapu, Andreas Roos   +17 more
wiley   +2 more sources

3D-environment and muscle contraction regulate the heterogeneity of myonuclei

Skeletal Muscle
Skeletal muscle formation involves tight interactions between muscle cells and associated connective tissue fibroblasts. Every muscle displays the same type of organisation, they are innervated in the middle and attached at both extremities to tendons ...
Rosa Nicolas, Marie-Ange Bonnin, Cédrine Blavet, Joana Esteves de Lima, Cécile Legallais, Delphine Duprez   +5 more
doaj   +4 more sources

Biochemical Isolation of Myonuclei from Mouse Skeletal Muscle Tissue

Bio-Protocol, 2017
Skeletal muscle provides the contractile force necessary for movement, swallowing, and breathing and, consequently, is necessary for survival. Skeletal muscle cells are unique in that they are extremely large cells containing thousands of nuclei.
Alicia Cutler, Anita Corbett, Grace Pavlath   +2 more
doaj   +4 more sources

Loss of Myonuclei and Transcriptional Activity During Diaphragm Atrophy in Critically Ill Patients [PDF]

Journal of Cachexia, Sarcopenia and Muscle
Background Diaphragm weakness frequently develops in critically ill patients and is explained by a combination of atrophy and myofiber dysfunction.
Wout J. Claassen, Marloes van denBerg, Zhong Hua Shi, Rianne. J. Baelde, Sylvia Bogaards, Luuk Bonis, Heleen Hakkeling, Arezou Bamyani, Gerben J. Schaaf, Albertus Beishuizen, Chris Dickhoff, Reinier A. Boon, Leo Heunks, Tyler J. Kirby, Coen A. C. Ottenheijm   +14 more
doaj   +2 more sources

SH3KBP1 promotes skeletal myofiber formation and functionality through ER/SR architecture integrity [PDF]

EMBO Reports
Dynamic changes in the arrangement of myonuclei and the organization of the sarcoplasmic reticulum are important determinants of myofiber formation and muscle function.
Alexandre Guiraud, Nathalie Couturier, Emilie Christin, Léa Castellano, Marine Daura, Carole Kretz-Remy, Alexandre Janin, Alireza Ghasemizadeh, Peggy del Carmine, Laloe Monteiro, Ludivine Rotard, Colline Sanchez, Vincent Jacquemond, Claire Burny, Stéphane Janczarski, Anne-Cécile Durieux, David Arnould, Norma Beatriz Romero, Mai Thao Bui, Vladimir L Buchman, Laura Julien, Marc Bitoun, Vincent Gache   +22 more
doaj   +2 more sources

Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance [PDF]

Nature Communications
The neuromuscular junction (NMJ) is the synapse formed between motor neurons and skeletal muscle fibers. Its stability relies on the continued expression of genes in a subset of myonuclei, called NMJ myonuclei.
Alexander S. Ham, Shuo Lin, Alice Tse, Marco Thürkauf, Timothy J. McGowan, Lena Jörin, Filippo Oliveri, Markus A. Rüegg   +7 more
doaj   +2 more sources

High-intensity interval training alleviates STZ-induced muscle atrophy by restoration of nuclear positioning defects in C57BL/6 male mice [PDF]

Scientific Reports
We tested the hypothesis that improper myonuclei arrangement and morphology are involved in diabetes-induced myofiber atrophy and whether and how high-intensity interval training (HIIT) affects these impairments in isolated skeletal muscle myofibers. STZ-
Masoud Rahmati, Rohollah Nikooie
doaj   +2 more sources