Results 21 to 30 of about 4,549 (160)
Displaced Myonuclei in Cancer Cachexia Suggest Altered Innervation [PDF]
International Journal of Molecular Sciences, 2020 An idiopathic myopathy characterized by central nuclei in muscle fibers, a hallmark of muscle regeneration, has been observed in cancer patients. In cancer cachexia skeletal muscle is incapable of regeneration, consequently, this observation remains unaccounted for.
Nissrine Daou +11 more
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Challenging Dogma about Myonuclei Behavior in Skeletal Muscle Cells
Function, 2023 Espen E Spangenburg
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Skeletal Muscle Activity and the Fate of Myonuclei [PDF]
Acta Naturae, 2010 Adult skeletal muscle fiber is a symplast multinuclear structure developed in ontogenesis by the fusion of the myoblasts (muscle progenitor cells). The nuclei of a muscle fiber (myonuclei) are those located at the periphery of fiber in the space between myofibrils and sarcolemma.
Shenkman, B. +3 more
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A Touch from Myofibroblasts Puts the Squeeze on Myonuclei [PDF]
Developmental Cell, 2018 The even positioning of nuclei at the periphery of differentiated myofibers is among the most striking examples of cellular organization. In this issue of Developmental Cell, Roman et al. (2018) show that fibronectin deposited by the associated myofibroblasts initiates both lateral and peripheral nuclear movements by distinct downstream mechanisms.
Torrey R, Mandigo, Eric S, Folker
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Frontiers in Cell and Developmental Biology, 2022 The nuclei of multinucleated skeletal muscles experience substantial external force during development and muscle contraction. Protection from such forces is partly provided by lamins, intermediate filaments that form a scaffold lining the inner nuclear ...
Nicholas M. Shaw +6 more
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Function, 2021 Using a mouse model of conditional and inducible in vivo fluorescent myonuclear labeling (HSA-GFP), sorting purification of nuclei, low-input reduced representation bisulfite sequencing (RRBS), and a translatable and reversible model of exercise ...
Yuan Wen +5 more
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Myonuclei acquired by overload exercise precede hypertrophy and are not lost on detraining [PDF]
Proceedings of the National Academy of Sciences, 2010 Effects of previous strength training can be long-lived, even after prolonged subsequent inactivity, and retraining is facilitated by a previous training episode. Traditionally, such “muscle memory” has been attributed to neural factors in the absence of any identified local memory mechanism in the muscle tissue. We have used in vivo imaging techniques
J C, Bruusgaard +4 more
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Magnetic Resonance Microscopy (MRM) of Single Mammalian Myofibers and Myonuclei [PDF]
Scientific Reports, 2017 AbstractRecently, the first magnetic resonance microscopy (MRM) images at the cellular level in isolated mammalian brain tissues were obtained using microsurface coils. These methods can elucidate the cellular origins of MR signals and describe how these signals change over the course of disease progression and therapy.
Choong H. Lee +5 more
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Decoding the transcriptome of denervated muscle at single‐nucleus resolution
Journal of Cachexia, Sarcopenia and Muscle, 2022 Background Skeletal muscle exhibits remarkable plasticity under both physiological and pathological conditions. One major manifestation of this plasticity is muscle atrophy that is an adaptive response to catabolic stimuli.
Hongchun Lin +6 more
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Frontiers in Physiology, 2016 Multiple sclerosis (MS) is associated with loss of skeletal muscle mass and function. The myogenic stem cells (satellite cells – SCs) are instrumental to accretion of myonuclei, but remain to be investigated in MS.
Jean eFarup +5 more
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