Results 31 to 40 of about 4,549 (160)

Effects of mechanical over-loading on the properties of soleus muscle fibers, with or without damage, in wild type and mdx mice. [PDF]

PLoS ONE, 2012
Effects of mechanical over-loading on the characteristics of regenerating or normal soleus muscle fibers were studied in dystrophin-deficient (mdx) and wild type (WT) mice.
Masahiro Terada, Fuminori Kawano, Takashi Ohira, Naoya Nakai, Norihiro Nishimoto, Yoshinobu Ohira   +5 more
doaj   +1 more source

Exclusive vital labeling of myonuclei for studying myonuclear arrangement in mouse skeletal muscle tissue

Skeletal Muscle, 2020
Background The arrangement of myonuclei in skeletal muscle tissue has long been used as a biomarker for muscle health, but there is a dearth of in vivo exploration of potential effects of myonuclear organization on the function and regeneration of ...
Robert Louis Hastings, Ryan T. Massopust, Seth G. Haddix, Young il Lee, Wesley J. Thompson   +4 more
doaj   +1 more source

Mechanotransduction via the LINC complex regulates DNA replication in myonuclei [PDF]

Journal of Cell Biology, 2018
Nuclear mechanotransduction has been implicated in the control of chromatin organization; however, its impact on functional contractile myofibers is unclear. We found that deleting components of the linker of nucleoskeleton and cytoskeleton (LINC) complex in Drosophila melanogaster larval muscles abolishes the controlled and synchronized DNA ...
Shuoshuo Wang, Elizabeth Stoops, Unnikannan CP, Barak Markus, Adriana Reuveny, Elly Ordan, Talila Volk   +6 more
openaire   +2 more sources

Skeletal Muscles Do Not Undergo Apoptosis During Either Atrophy or Programmed Cell Death-Revisiting the Myonuclear Domain Hypothesis

Frontiers in Physiology, 2019
Skeletal muscles are the largest cells in the body and are one of the few syncytial ones. There is a longstanding belief that a given nucleus controls a defined volume of cytoplasm, so when a muscle grows (hypertrophy) or shrinks (atrophy), the number of
Lawrence M. Schwartz
doaj   +1 more source

Roles played by protein metabolism and myogenic progenitor cells in exercise-induced muscle hypertrophy and their relation to resistance training regimens

Journal of Physical Fitness and Sports Medicine, 2012
To learn the mechanisms underlying resistance exercise-induced muscle hypertrophy, recent studies on muscle protein metabolism and myogenic progenitor cells were reviewed. Numerous studies have suggested that activation of the translation process plays a
Naokata Ishii, Riki Ogasawara, Koji Kobayashi, Koichi Nakazato   +3 more
doaj   +1 more source

Functional specialisation and coordination of myonuclei

Biological Reviews
ABSTRACTMyofibres serve as the functional unit for locomotion, with the sarcomere as fundamental subunit. Running the entire length of this structure are hundreds of myonuclei, located at the periphery of the myofibre, juxtaposed to the plasma membrane.
Korb, Amaury, Tajbakhsh, Shahragim, Comai, Glenda   +2 more
openaire   +3 more sources

Myonuclear Domain Flexibility Challenges Rigid Assumptions on Satellite Cell Contribution to Skeletal Muscle Fiber Hypertrophy

Frontiers in Physiology, 2018
Satellite cell-mediated myonuclear accretion is thought to be required for skeletal muscle fiber hypertrophy, and even drive hypertrophy by preceding growth. Recent studies in humans and rodents provide evidence that challenge this axiom.
Kevin A. Murach, Kevin A. Murach, Davis A. Englund, Davis A. Englund, Esther E. Dupont-Versteegden, Esther E. Dupont-Versteegden, John J. McCarthy, John J. McCarthy, Charlotte A. Peterson, Charlotte A. Peterson   +9 more
doaj   +1 more source

Myonuclear permanence in skeletal muscle memory: a systematic review and meta‐analysis of human and animal studies

Journal of Cachexia, Sarcopenia and Muscle, 2022
One aspect of skeletal muscle memory is the ability of a previously trained muscle to hypertrophy more rapidly following a period of detraining. Although the molecular basis of muscle memory remains to be fully elucidated, one potential mechanism thought
Masoud Rahmati, John J. McCarthy, Fatemeh Malakoutinia   +2 more
doaj   +1 more source

Nuclei of aged myofibres undergo structural and functional changes suggesting impairment in RNA processing

European Journal of Histochemistry, 2009
Advancing adult age is associated with a progressive decrease in skeletal muscle mass, strength and quality known as sarcopenia. The mechanisms underlying age-related skeletal muscle wasting and weakness are manifold and still remain to be fully ...
C Pellicciari, C Zancanaro, S Muller, F Perdoni, M Malatesta   +4 more
doaj   +3 more sources

Electrical Modalities in the Rehabilitation of Peripheral Nerve Injuries: State of the Literature and Current Clinical Applications

Muscle &Nerve, EarlyView.
ABSTRACT Peripheral nerve injuries (PNIs) are a common cause of long‐term motor and sensory disability despite advances in microsurgical repair. Functional recovery following PNI depends not only on axonal regeneration, but also on preservation of distal nerve pathways, maintenance of neuromuscular junction integrity, prevention of irreversible muscle ...
Sarah M. Smith, Kirsten M. Schlosser, Ranee Munaim, Stephanie H. Vu, JulieAnn H. Uh, Yusha K. Liu   +5 more
wiley   +1 more source