Results 51 to 60 of about 4,549 (160)

Uncoordinated transcription and compromised muscle function in the lmna-null mouse model of Emery- Emery-Dreyfuss muscular dystrophy.

open access: yesPLoS ONE, 2011
LMNA encodes both lamin A and C: major components of the nuclear lamina. Mutations in LMNA underlie a range of tissue-specific degenerative diseases, including those that affect skeletal muscle, such as autosomal-Emery-Dreifuss muscular dystrophy (A-EDMD)
Viola F Gnocchi   +9 more
doaj   +1 more source

Satellite cell proliferation and myofiber cross-section area increase after electrical stimulation following sciatic nerve crush injury in rats

open access: yesChinese Medical Journal, 2020
. Background. Electrical stimulation has been recommended as an effective therapy to prevent muscle atrophy after nerve injury. However, the effect of electrical stimulation on the proliferation of satellite cells in denervated muscles has not yet been ...
Hua-Yi Xing   +3 more
doaj   +1 more source

Designing the MyoFusion Media: A Serum‐Free Medium Optimized for Bovine Satellite Cell Differentiation

open access: yesBiotechnology and Bioengineering, Volume 123, Issue 8, Page 2048-2061, August 2026.
ABSTRACT Cultivated meat production requires efficient differentiation of muscle progenitor cells into myotubes without relying on animal‐derived serum, which poses ethical and scalability challenges. This study aimed to develop a chemically defined, serum‐free medium optimized for bovine satellite cell differentiation.
Aysenaz Tavsanli   +3 more
wiley   +1 more source

The Impact of Ageing on Skeletal Muscle: Roles of Mitochondrial Dysregulation, Systemic Communication, and Exercise

open access: yesJournal of Cellular Physiology, Volume 241, Issue 8, August 2026.
ABSTRACT Ageing is a major risk factor for degenerative diseases, including sarcopenia, which is characterized by a progressive loss of skeletal muscle mass and function, frailty, and is associated with increased mortality. Skeletal muscle regeneration relies on muscle stem cells and efficient communication with cellular microenvironment.
Juan Diego Hernández‐Camacho   +1 more
wiley   +1 more source

Nuclear Positioning in Muscle Development and Disease

open access: yesFrontiers in Physiology, 2013
Muscle disease as a group is characterized by muscle weakness, muscle loss, and impaired muscle function. Although the phenotype is the same, the underlying cellular pathologies, and the molecular causes of these pathologies, are diverse.
Eric eFolker, Mary eBaylies
doaj   +1 more source

Dnajb5 From Antarctic Fish Reveals a Redox‐Sensitive Mechanism Coordinating Muscle Regeneration via mTORC1 and HDAC4

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Dnajb5, a member of the heat shock protein family, has not been previously reported to play a role in muscle differentiation. We identify Dnajb5 as a negative regulator of myogenesis via mammalian target of rapamycin (mTOR) and histone deacetylase 4 (HDAC4) signalling, functioning as a central controller of muscle growth and ...
Sun‐Hee Cho   +8 more
wiley   +1 more source

Fast and slow myofiber nuclei, satellite cells, and size distribution with lifelong endurance exercise in men and women

open access: yesPhysiological Reports
We previously observed lifelong endurance exercise (LLE) influenced quadriceps whole‐muscle and myofiber size in a fiber‐type and sex‐specific manner.
Cristhian F. Montenegro   +8 more
doaj   +1 more source

Effects of long term supplementation of anabolic androgen steroids on human skeletal muscle. [PDF]

open access: yesPLoS ONE, 2014
The effects of long-term (over several years) anabolic androgen steroids (AAS) administration on human skeletal muscle are still unclear. In this study, seventeen strength training athletes were recruited and individually interviewed regarding self ...
Ji-Guo Yu   +5 more
doaj   +1 more source

Effect of belt electrode-skeletal muscle electrical stimulation on immobilization-induced muscle fibrosis.

open access: yesPLoS ONE, 2021
PurposeMacrophage accumulation in response to decreasing myonuclei may be the major mechanism underlying immobilization-induced muscle fibrosis in muscle contracture, an intervention strategy suppressing these lesions is necessary.
Yuichiro Honda   +8 more
doaj   +1 more source

Differential Myopathic and Transcriptomic Changes in Soleus and Gastrocnemius Muscles in a Novel Chronic Hindlimb Ischemia Rat Model Induced by Endovascular Catheter Occlusion

open access: yesActa Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Peripheral artery disease (PAD) is a progressive atherothrombotic disorder affecting more than 230 million people worldwide. Conventional animal models of chronic hindlimb ischemia (HLI) are highly invasive, technically challenging, fail to account for anatomical variation, and may not accurately recapitulate progressive PAD pathophysiology ...
Oliver Kitzerow   +4 more
wiley   +1 more source

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