Results 61 to 70 of about 4,549 (160)
The FEBS Journal, Volume 293, Issue 15, Page 4624-4644, August 2026.Alpha‐crystallin B chain (CRYAB) has been reported to stabilize mothers against decapentaplegic homolog 4 (SMAD4) in transforming growth factor‐β (TGF‐β) signaling, enabling target gene transcription. We show nuclear CRYAB–SMAD4 interaction for the first time in human skeletal muscle fibers and its regulation by exercise.
Kirill Schaaf +7 more
wiley +1 more source
Satellite cells and myonuclei in long‐term denervated rat muscles
The Anatomical Record, 1995 AbstractBackground: The percentage of satellite cells rapidly decreases in aneurally regenerating soleus muscles of rat. Also denervation of intact muscles causes fiber loss and regeneration, but the fate of satellite cells is unknown; myonuclei have been suggested to undergo changes resembling those in apoptotic cells.Methods: Rat soleus and extensor ...
Rodrigues, A. de Castro +1 more
openaire +3 more sources
Overexpression of the double homeodomain protein DUX4c interferes with myofibrillogenesis and induces clustering of myonuclei [PDF]
Skeletal Muscle, 2018 Facioscapulohumeral muscular dystrophy (FSHD) is associated with DNA hypomethylation at the 4q35 D4Z4 repeat array. Both the causal gene DUX4 and its homolog DUX4c are induced. DUX4c is immunodetected in every myonucleus of proliferative cells, while DUX4 is present in only 1/1000 of myonuclei where it initiates a gene deregulation cascade.
Vanderplanck, Céline +9 more
openaire +4 more sources
Experimental Physiology, Volume 111, Issue 8, Page 3502-3513, 1 August 2026.Abstract Standard chemotherapy regimens for patients with breast cancer are based on epirubicin–cyclophosphamide (EC) and paclitaxel (TAX) administrations. While it has been shown that first EC administration impairs mitochondrial homeostasis, the isolated effects of TAX have not been studied without previous chemotherapy exposure.
Joris Mallard +10 more
wiley +1 more source
Myonuclear Dynamics After Skeletal Muscle Surgical Injury
The FASEB Journal, Volume 40, Issue 14, 31 July 2026.Using a recombination‐independent doxycycline inducible model of timed nonsatellite cell‐derived myonuclear labeling in adult skeletal muscle, we show that resident myonuclei move and become displaced within intact muscle fibers after muscle surgical injury.
Micah Goeke +3 more
wiley +1 more source
Long-Term Endurance Exercise in Humans Stimulates Cell Fusion of Myoblasts along with Fusogenic Endogenous Retroviral Genes In Vivo. [PDF]
PLoS ONE, 2015 Myogenesis is defined as growth, differentiation and repair of muscles where cell fusion of myoblasts to multinucleated myofibers is one major characteristic.
Sebastian Frese +17 more
doaj +1 more source
The FASEB Journal, Volume 40, Issue 13, 15 July 2026.Simvastatin induces metabolic suppression, mitochondrial dysfunction, and atrophy‐related responses in skeletal muscle cells. In differentiated C2C12 myotubes, metformin partially attenuates these alterations by preserving myotube structural integrity, reducing cellular stress signaling, and maintaining mitochondrial network organization despite ...
Chuqi He +6 more
wiley +1 more source
Muscular dystrophy: Centronucleation may reflect a compensatory activation of defective myonuclei
Journal of Biomedical Science, 1998 Muscular dystrophy has long been believed to be characterized by degeneration and abortive regeneration of muscle fibers (the muscle degeneration theory), but unfortunately its pathogenesis is still unclear and an effective treatment has yet to be developed.
T, Totsuka +4 more
openaire +2 more sources
The myonuclear DNA methylome in response to an acute hypertrophic stimulus
Epigenetics, 2020 In addition to multi-nucleated muscle fibres, numerous resident and infiltrating mononuclear cells populate the muscle compartment. As most epigenetic assays in skeletal muscle are conducted on whole tissue homogenates, essentially nothing is known about
Ferdinand Von Walden +6 more
doaj +1 more source
A Myocyte‐Enriched Long Non‐Coding RNA NRMLncR Enhances Myogenesis in Mouse
The FASEB Journal, Volume 40, Issue 13, 15 July 2026.We identified a novel myocyte‐enriched, Notch‐repressed myogenic lncRNA, NRMLncR, that is induced by myogenic regulatory factors (MRFs) during myogenic progression in mouse. NRMLncR localizes to cytoplasmic and nuclear compartments, associates with the RNA‐binding protein CUGBP Elav‐like family member 1 (CELF1), and is linked to neighboring gene Tbx1 ...
Yufen Li +12 more
wiley +1 more source