Results 71 to 80 of about 4,549 (160)

Unraveling the spatial landscape of dystrophinopathies: a transcriptomic approach to Becker and Duchenne muscular dystrophies

The Journal of Pathology, Volume 269, Issue 3, Page 363-380, July 2026.
Abstract Dystrophinopathies are caused by pathogenic variants in the DMD gene, resulting in partial (Becker) or complete loss (Duchenne) of dystrophin. Becker (BMD) and Duchenne muscular dystrophy (DMD) are characterized by progressive muscle wasting, fatty replacement, fibrosis, and loss of function.
Laura GM Heezen, Qirong Mao, Stefan Nicolau, Claudio Novella Rausell, Julia van der Weerd, Jan Kueckelhaus, Rasya Gokul Nath, Jordi Diaz‐Manera, Hermien E Kan, Erik H Niks, Maaike van Putten, Annemieke Aartsma‐Rus, Kevin M Flanigan, Ahmed Mahfouz, Pietro Spitali   +14 more
wiley   +1 more source

Blood flow‐restricted resistance exercise: rapidly affecting the myofibre and the myonuclei

The Journal of Physiology, 2012
Acute blood flow restriction (BFR) by itself or in combination with low-intensity aerobic and/or low-load resistance exercise has been shown to result in favourable effects on skeletal muscle, namely increases in muscle size and strength (Loenneke et al. 2012). These positive muscular adaptations have been observed across a wide range of populations (e.
Jeremy P, Loenneke, Robert S, Thiebaud, Christopher A, Fahs, Lindy M, Rossow   +3 more
openaire   +3 more sources

Fiber Type-Specific Satellite Cell Content in Cyclists Following Heavy Training With Carbohydrate and Carbohydrate-Protein Supplementation

Frontiers in Physiology, 2016
The central purpose of this study was to evaluate the fiber type-specific satellite cell and myonuclear responses of endurance-trained cyclists to a block of intensified training, when supplementing with carbohydrate (CHO) vs. carbohydrate-protein (PRO).
Alec I McKenzie, Andrew C D'Lugos, Michael J Saunders, Keith D Gworek, Nicholas D Luden   +4 more
doaj   +1 more source

Standardization of Immunohistochemistry Using an Anti‐WASLB Antibody in the Skeletal Muscle of Teleost Fish

Current Protocols, Volume 6, Issue 6, June 2026.
Abstract Immunohistochemistry (IHC) is a widely used technique for the identification, localization, and analysis of protein expression in tissues, playing a critical role in pathological diagnosis and validation of data derived from molecular biology. Despite its well‐established use in mammalian tissues, applying IHC to fish still presents challenges,
Erika Stefani Perez, Matheus Naia Fioretto, Bruna Tereza Thomazini Zanella, Rafael Henrique Nóbrega, Bruno Oliveira da Silva Duran, Maeli Dal Pai‐Silva   +5 more
wiley   +1 more source

Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle

eLife, 2019
In overloaded and regenerating muscle, the generation of new myonuclei depends on muscle satellite cells (MuSCs). Because MuSC behaviors in these two environments have not been considered separately, MuSC behaviors in overloaded muscle remain unexamined.
Sumiaki Fukuda, Akihiro Kaneshige, Takayuki Kaji, Yu-taro Noguchi, Yusei Takemoto, Lidan Zhang, Kazutake Tsujikawa, Hiroki Kokubo, Akiyoshi Uezumi, Kazumitsu Maehara, Akihito Harada, Yasuyuki Ohkawa, So-ichiro Fukada   +12 more
doaj   +1 more source

SARM Rad140 Increases Osteoblasts, Muscle Fiber Size, Myonuclei, and Reduces Osteoclasts in Orchidectomized Wistar Rats

MCBS (Molecular and Cellular Biomedical Sciences)
Background: Orchidectomy is a surgical androgen deprivation therapy (ADT) for prostate cancer patients to achieve castrate testosterone levels. Selective androgen receptor modulators (SARMs) are used to mitigate the adverse effects of ADT, including ...
Taufiq Nur Budaya, Besut Daryanto, Kurnia Penta Seputra, Dio Mafazi Fabrianta, Aditya Airlangga Ekaputra, RA Rose Khasana Dewi, Kenty Wantri Anita, Fauzan Kurniawan Dhani, Amira Fithri Rofifa   +8 more
doaj   +1 more source

Spatial and mechanical environments regulate the heterogeneity of myonuclei

Abstract Skeletal muscle formation involves tight interactions between muscle cells and associated connective tissue fibroblasts. Every muscle displays the same type of organisation, they are innervated in the middle and attached at both extremities to tendons.
Nicolas, Rosa, Bonnin, Marie-Ange, Blavet, Cédrine, Lima, Joana Esteves, Legallais, Cécile, Duprez, Delphine   +5 more
openaire   +2 more sources

Recent advances in understanding skeletal muscle ageing: Functional, morphological and omics perspectives

Experimental Physiology, Volume 111, Issue 7, Page 3127-3129, 1 July 2026.
Oscar Horwath, William Apró
wiley   +1 more source

Developmental Programming in Response to Intrauterine Growth Restriction Impairs Myoblast Function and Skeletal Muscle Metabolism

Journal of Pregnancy, 2012
Fetal adaptations to placental insufficiency alter postnatal metabolic homeostasis in skeletal muscle by reducing glucose oxidation rates, impairing insulin action, and lowering the proportion of oxidative fibers.
D. T. Yates, A. R. Macko, M. Nearing, X. Chen, R. P. Rhoads, S. W. Limesand   +5 more
doaj   +1 more source

Shift from Pro- to Anti-Inflammatory Phase in Pelvic Floor Muscles at Postpartum Matches Histological Signs of Regeneration in Multiparous Rabbits

Medicina
Background and Objectives: Pelvic floor muscles (PFM) play a core role in defecation and micturition. Weakening of PFM underlies urogynecological disorders such as pelvic organ prolapse and stress urinary incontinence.
Esteban Rodríguez-Benítez, Kenia López-García, Nicte Xelhuantzi, Dora Luz Corona-Quintanilla, Francisco Castelán, Margarita Martínez-Gómez   +5 more
doaj   +1 more source