The Evolution of the Scavenger Receptor Cysteine-Rich Domain of the Class A Scavenger Receptors [PDF]
Frontiers in Immunology, 2015 The class A Scavenger Receptor (cA-SR) family is a group of five evolutionarily related innate immune receptors. The cA-SRs are known for their promiscuous ligand binding; as they have been shown to bind bacteria such as Streptococcus pneumoniae, and ...
Nicholas eYap +3 more
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Scavenger receptors in host defense: from functional aspects to mode of action [PDF]
Cell Communication and Signaling, 2022 Scavenger receptors belong to a superfamily of proteins that are structurally heterogeneous and encompass the miscellaneous group of transmembrane proteins and soluble secretory extracellular domain.
Qamar Taban +4 more
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Macrophage scavenger receptors: Tumor support and tumor inhibition [PDF]
Frontiers in Oncology, 2023 Tumor-associated macrophages (TAMs) are a heterogeneous population of myeloid cells that constitute up to 50% of the cell mass of human tumors. TAMs interact with the components of the tumor microenvironment (TME) by using scavenger receptors (SRs), a ...
Elena Kazakova +10 more
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Alpha-Fetoprotein Binding Mucin and Scavenger Receptors: An Available Bio-Target for Treating Cancer [PDF]
Frontiers in Oncology, 2021 Alpha-fetoprotein (AFP) entrance into cancer cells is mediated by AFP receptors (AFPRs) and exerts malignant effects. Therefore, understanding the structure of AFPRs will facilitate the development of rational approaches for vaccine design, drug delivery,
Bo Lin +6 more
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Targeting Scavenger Receptors in Inflammatory Disorders and Oxidative Stress [PDF]
Antioxidants, 2022 Oxidative stress and inflammation cannot be considered as diseases themselves; however, they are major risk factors for the development and progression of the pathogenesis underlying many illnesses, such as cancer, neurological disorders (including ...
Govigerel Bayarsaikhan +3 more
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More Than Just a Removal Service: Scavenger Receptors in Leukocyte Trafficking [PDF]
Frontiers in Immunology, 2018 Scavenger receptors are a highly diverse superfamily of proteins which are grouped by their inherent ability to bind and internalize a wide array of structurally diverse ligands which can be either endogenous or exogenous in nature.
Daniel A. Patten, Shishir Shetty
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Journal of Lipid Research, 1981 Improved techniques of cell isolation resulted in 90 to 100 million monocytes from a single donor. Addition of low density lipoprotein (LDL) to to cultures of these cells resulted in the down regulation of LDL receptor activity.
A M Fogelman +4 more
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Scavenger Receptors as Biomarkers and Therapeutic Targets in Cardiovascular Disease [PDF]
Cells, 2020 The process of atherosclerosis leads to the formation of plaques in the arterial wall, resulting in a decreased blood supply to tissues and organs and its sequelae: morbidity and mortality.
Gary A. Cuthbert +4 more
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Immunological Outcomes Mediated Upon Binding of Heat Shock Proteins to Scavenger Receptors SCARF1 and LOX-1, and Endocytosis by Mononuclear Phagocytes [PDF]
Frontiers in Immunology, 2020 Heat shock proteins (HSP) are a highly abundant class of molecular chaperones that can be released into the extracellular milieu and influence the immune response. HSP release can occur when cells undergo necrosis and exude their contents.
Ayesha Murshid +6 more
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Identification of scavenger receptors and thrombospondin‐type‐1 repeat proteins potentially relevant for plastid recognition in Sacoglossa [PDF]
Ecology and Evolution, 2020 Functional kleptoplasty is a photosymbiotic relationship, in which photosynthetically active chloroplasts serve as an intracellular symbiont for a heterotrophic host.
Jenny Melo Clavijo +6 more
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