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The Evolution of the Scavenger Receptor Cysteine-Rich Domain of the Class A Scavenger Receptors [PDF]
Frontiers in Immunology, 2015 The class A Scavenger Receptor (cA-SR) family is a group of five evolutionarily related innate immune receptors. The cA-SRs are known for their promiscuous ligand binding; as they have been shown to bind bacteria such as Streptococcus pneumoniae, and ...
Nicholas eYap +3 more
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The evolution of the class A scavenger receptors [PDF]
BMC Evolutionary Biology, 2012 Background The class A scavenger receptors are a subclass of a diverse family of proteins defined based on their ability to bind modified lipoproteins. The 5 members of this family are strikingly variable in their protein structure and function, raising ...
Whelan Fiona J +4 more
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Scavenger receptors in host defense: from functional aspects to mode of action [PDF]
Cell Communication and Signaling, 2022 Scavenger receptors belong to a superfamily of proteins that are structurally heterogeneous and encompass the miscellaneous group of transmembrane proteins and soluble secretory extracellular domain.
Qamar Taban +4 more
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Curr Biol, 2020 Scavenger receptors (SRs) are a large family of cell-surface receptors that are diverse in their structure and biological function and are divided into different classes. SRs can bind to a range of ligands and enhance the elimination of altered-self or non-self targets.
Alquraini A, El Khoury J.
europepmc +4 more sources
Macrophage scavenger receptors: Tumor support and tumor inhibition [PDF]
Frontiers in Oncology, 2023 Tumor-associated macrophages (TAMs) are a heterogeneous population of myeloid cells that constitute up to 50% of the cell mass of human tumors. TAMs interact with the components of the tumor microenvironment (TME) by using scavenger receptors (SRs), a ...
Elena Kazakova +10 more
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Alpha-Fetoprotein Binding Mucin and Scavenger Receptors: An Available Bio-Target for Treating Cancer [PDF]
Frontiers in Oncology, 2021 Alpha-fetoprotein (AFP) entrance into cancer cells is mediated by AFP receptors (AFPRs) and exerts malignant effects. Therefore, understanding the structure of AFPRs will facilitate the development of rational approaches for vaccine design, drug delivery,
Bo Lin +6 more
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Targeting Scavenger Receptors in Inflammatory Disorders and Oxidative Stress [PDF]
Antioxidants, 2022 Oxidative stress and inflammation cannot be considered as diseases themselves; however, they are major risk factors for the development and progression of the pathogenesis underlying many illnesses, such as cancer, neurological disorders (including ...
Govigerel Bayarsaikhan +3 more
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Scavenger Receptors and Atherosclerosis
Biological Research, 2000 Scavenger receptors were discovered as cell surface proteins capable of binding and internalization of modified lipoproteins. These receptors exhibit a broad ligand binding specificity including potential physiological and pathophysiological ligands ...
ATTILIO RIGOTTI
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More Than Just a Removal Service: Scavenger Receptors in Leukocyte Trafficking [PDF]
Frontiers in Immunology, 2018 Scavenger receptors are a highly diverse superfamily of proteins which are grouped by their inherent ability to bind and internalize a wide array of structurally diverse ligands which can be either endogenous or exogenous in nature.
Daniel A. Patten, Shishir Shetty
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Journal of Lipid Research, 1981 Improved techniques of cell isolation resulted in 90 to 100 million monocytes from a single donor. Addition of low density lipoprotein (LDL) to to cultures of these cells resulted in the down regulation of LDL receptor activity.
A M Fogelman +4 more
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