Results 11 to 20 of about 59,530 (304)

The SCFA Receptor GPR43 and Energy Metabolism [PDF]

Frontiers in Endocrinology, 2014
Free fatty acids (FFAs) are essential nutrients and act as signaling molecules in various cellular processes via binding with FFA receptors. Of these receptors, GPR43 is activated by short-chain fatty acids (SCFAs; e.g., acetate, propionate, and butyrate).
Ikuo eKimura, Ikuo eKimura, Daisuke eInoue, Kanako eHirano, Gozoh eTsujimoto   +4 more
openaire   +3 more sources

SCFA: mechanisms and functional importance in the gut [PDF]

Proceedings of the Nutrition Society, 2020
In recent years, the importance of the gut microbiota in human health has been revealed and many publications have highlighted its role as a key component of human physiology. Owing to the use of modern sequencing approaches, the characterisation of the microbiome in healthy individuals and in disease has demonstrated a disturbance of the microbiota ...
Camille Martin-Gallausiaux, Ludovica Marinelli, Hervé M. Blottière, Pierre Larraufie, Nicolas Lapaque   +4 more
openaire   +2 more sources

A compromised developmental trajectory of the infant gut microbiome and metabolome in atopic eczema

Gut Microbes, 2020
Evidence is accumulating that the establishment of the gut microbiome in early life influences the development of atopic eczema. In this longitudinal study, we used integrated multi-omics analyses to infer functional mechanisms by which the microbiome ...
Le Duc Huy Ta, James Chun Yip Chan, Gaik Chin Yap, Rikky W. Purbojati, Daniela I. Drautz-Moses, Yanqing Michelle Koh, Carina Jing Xuan Tay, Chiung-Hui Huang, Dorinda Yan Qin Kioh, Jia Yun Woon, Elizabeth Huiwen Tham, Evelyn Xiu Ling Loo, Lynette P.C. Shek, Neerja Karnani, Anne Goh, Hugo P.S. Van Bever, Oon Hoe Teoh, Yiong Huak Chan, Christophe Lay, Jan Knol, Fabian Yap, Kok Hian Tan, Yap-Seng Chong, Keith M. Godfrey, Staffan Kjelleberg, Stephan C. Schuster, Eric Chun Yong Chan, Bee Wah Lee   +27 more
doaj   +1 more source

Dietary betaine prevents obesity through gut microbiota-drived microRNA-378a family

Gut Microbes, 2021
Betaine is a natural compound present in commonly consumed foods and may have a potential role in the regulation of glucose and lipids metabolism. However, the underlying molecular mechanism of its action remains largely unknown.
Jingjing Du, Peiwen Zhang, Jiang Luo, Linyuan Shen, Shunhua Zhang, Hao Gu, Jin He, Linghui Wang, Xue Zhao, Mailing Gan, Liu Yang, Lili Niu, Ye Zhao, Qianzi Tang, Guoqing Tang, Dongmei Jiang, Yanzhi Jiang, Mingzhou Li, Anan Jiang, Long Jin, Jideng Ma, Surong Shuai, Lin Bai, Jinyong Wang, Bo Zeng, De Wu, Xuewei Li, Li Zhu   +27 more
doaj   +1 more source

Role of gut microbiota in the aetiology of obesity: proposed mechanisms and review of the literature [PDF]

, 2016
The aetiology of obesity has been attributed to several factors (environmental, dietary, lifestyle, host, and genetic factors); however none of these fully explain the increase in the prevalence of obesity worldwide.
Edwards, Christine Ann, Gerasimidis, Konstantinos, Khan, Muhammad Jaffar, Shaikh, M. Guftar   +3 more
core   +3 more sources

Modified Mediterranean Diet for Enrichment of Short Chain Fatty Acids: Potential Adjunctive Therapeutic to Target Immune and Metabolic Dysfunction in Schizophrenia? [PDF]

, 2017
Growing interest in gut and digestive processes and their potential link to brain and peripheral based inflammation or biobehavioral phenotypes has led to an increasing number of basic and translational scientific reports focused on the role of gut ...
Cadenhead, Kristen S, Depp, Colin, Joseph, Jamie, Schmid-Schönbein, Geert, Shih, Pei-An B   +4 more
core   +1 more source

SCFA transport in rat duodenum

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2015
Bacterial or ingested food-derived short-chain fatty acids (SCFAs) are present in the duodenal lumen. Acetate, the most abundant SCFA in the foregut lumen, is absorbed immediately after ingestion, although the mechanism by which this absorption occurs is not fully understood. We investigated the distribution and function of candidate SCFA transporters
Izumi, Kaji, Toshihiko, Iwanaga, Masahiko, Watanabe, Paul H, Guth, Eli, Engel, Jonathan D, Kaunitz, Yasutada, Akiba   +6 more
openaire   +3 more sources

SCFAs Control Skin Immune Responses via Increasing Tregs [PDF]

Journal of Investigative Dermatology, 2017
We are surrounded by billions of microbes, and our immune system is substantially affected by the commensal bacteria on the surface of our body. Schwarz et al. describe the immune-suppressive effect of sodium butyrate, a bacterial metabolite that is categorized as one of the short-chain fatty acids, during skin inflammatory responses.
Gyohei, Egawa, Tetsuya, Honda, Kenji, Kabashima   +2 more
openaire   +2 more sources

The influence of orally administered short chain fatty acids on intestinal histopathological changes and intensity of Trichinella spiralis infection in mice

Veterinární Medicína, 2010
The influence of short chain fatty acids (SCFA) on histopathological changes in the small intestine and the intensity of invasion of T. spiralis in mice were investigated in this study. The animals were infected with doses of 500 and 250 T.
D. Mista, J. Piekarska, M. Houszka, W. Zawadzki, M. Gorczykowski   +4 more
doaj   +1 more source

Dietary bioactive lipid compounds rich in menthol alter Interactions among members of ruminal microbiota in sheep [PDF]

, 2019
This study aimed to investigate the effects of two practically relevant doses of menthol-rich plant bioactive lipid compounds (PBLC) on fermentation, microbial community composition, and their interactions in sheep rumen.
Aschenbach, Jörg R., Braun, Hannah-Sophie, Geiger, Sebastian, Park, Tansol, Patra, Amlan K., Pieper, Robert, Yu, Zhongtang   +6 more
core   +1 more source