Heat Stress Triggers Nuclear Invagination and Spatial Compartmentalization of Protein Metabolism
Cell Proliferation, EarlyView.Cells adapt heat stress to shape a nuclear invagination region function as “protein metabolism hotspots”, where both protein production and degradation are enhanced. ABSTRACT Heat stress is a common challenge for cells, causing multiple types of cellular damage while triggering complex stress responses, including the highly conserved mechanism known as
Zhi‐Hao Zhang +11 more
wiley +1 more source
European Journal of Haematology, EarlyView.ABSTRACT Adult T‐cell leukemia/lymphoma (ATL) is an aggressive hematological malignancy with a poor prognosis and limited therapeutic options. ATL cells exhibit aberrant surface glycosylation patterns resulting from dysregulated glycosyltransferase expression, representing a potentially tumor‐specific therapeutic target.
Yuichiro Uchida +7 more
wiley +1 more source
Beyond Starch: Towards a Scalable Potato Platform for Molecular Farming
Plant Biotechnology Journal, EarlyView.Re‐engineering potato as a biosafe and host‐optimised platform for plant molecular farming by integrating intrinsic biological traits with targeted engineering strategies. ABSTRACT Thirty‐five years after the first recombinant protein was produced in potato and 30 years after clinical trials of edible vaccines from its tubers, the crop is being ...
Izabela Anna Chincinska +2 more
wiley +1 more source
EXTH-08. REPLACEMENT OF MICROGLIA BY BRAIN-ENGRAFTED MACROPHAGES PREVENTS MEMORY DEFICITS AFTER THERAPEUTIC WHOLE-BRAIN IRRADIATION [PDF]
, 2019 Microglia have a distinct origin compared to blood circulating myeloid cells. Under normal physiological conditions, microglia are maintained by self-renewal, independent of hematopoietic progenitors. Following genetic or pharmacologic depletion, newborn
Boosalis, Zoe +6 more
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Tool development for analysis of scFv NGS data in databases related to 3D structures: evolution of antibodies In silico [PDF]
, 2021 Mathias Coelho Batista +5 more
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Protein Science, Volume 35, Issue 6, June 2026.Abstract Membrane fusion between HIV and host cells requires interaction between the N‐terminal and C‐terminal repeat regions (NHR and CHR) of the gp41 envelope subunit. A deep hydrophobic pocket (HP) on the surface of NHR is considered crucial in this interaction.
Daniel Polo‐Megías +9 more
wiley +1 more source
Identification of a WSSV neutralizing scFv antibody by phage display technology and in vitro screening [PDF]
, 2006 Yuan Li +8 more
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Protein design and RNA design: Perspectives
Quantitative Biology, Volume 14, Issue 2, June 2026.Abstract Advances in deep learning and generative modeling have transformed the landscape of protein and RNA design, enabling rapid and precise creation of novel biomolecules with tailored structures and functions. In protein design, generative deep learning frameworks now support backbone generation, sequence optimization, and joint sequence–structure
Xi Chen, Xu Dai, Peilong Lu
wiley +1 more source
Genetically Engineered T-Cells for Malignant Glioma: Overcoming the Barriers to Effective Immunotherapy. [PDF]
, 2018 Malignant gliomas carry a dismal prognosis. Conventional treatment using chemo- and radiotherapy has limited efficacy with adverse events. Therapy with genetically engineered T-cells, such as chimeric antigen receptor (CAR) T-cells, may represent a ...
Almeida, Neil D +4 more
core
Bioinformatics in molecular immunology laboratories demonstrated: Modeling an anti-CMV scFv antibody [PDF]
, 2006 Chua Kek Heng, Rofina Yasmin Othman
openalex +1 more source