Results 181 to 190 of about 35,905 (251)

Mechanisms of Action and Limitations of Monoclonal Antibodies and Single Chain Fragment Variable (scFv) in the Treatment of Cancer

Biomedicines, 2023
Monoclonal antibodies are among the most effective tools for detecting tumor-associated antigens. The U.S. Food and Drug Administration (FDA) has approved more than 36 therapeutic antibodies for developing novel alternative therapies that have ...
Amalia Vences-Velázquez, Eugenia Flores-Alfaro, Luz Del Carmen Alarc´On-Romero   +2 more
exaly   +2 more sources

Targeted nanomedicine with anti-EGFR scFv for siRNA delivery into triple negative breast cancer cells

European Journal of Pharmaceutics and Biopharmaceutics, 2020
A targeted nanomedicine with humanized anti-EGFR scFv (NM-scFv) was developed for siRNA delivery into triple negative breast cancer (TNBC) cells. NM-scFv consisted of i) targeted nanovector (NV-scFv): nano-cargo with targeting properties; ii) siRNA ...
Catherine Passirani, Stephanie David, Katel Hervé Aubert   +2 more
exaly   +2 more sources

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Deciphering Protein Corona by scFv-Based Affinity Chromatography.

Nano letters (Print), 2021
It remains challenging to precisely decipher the structural and functional characteristics of protein coronas. To overcome the drawbacks frequently occurring in the traditional separation methods, an anti-PEG single-chain variable fragment (PEG-scFv ...
Yuxiu Chu, Wenjing Tang, Zui Zhang, Cheng Li, Jun Qian, Xiaoli Wei, T. Ying, Weiyue Lu, Changyou Zhan   +8 more
semanticscholar   +1 more source

Impact of scFv structure in chimeric antigen receptor on receptor expression efficiency and antigen recognition properties.

Biochemical and Biophysical Research Communications - BBRC, 2020
Gene-modifying T cells expressing chimeric antigen receptor (CAR) with an extracellular domain consisting of single chain variable fragment (scFv) and an intracellular domain with a T cell activation motif, are promising cancer immuno-medicines that can ...
K. Fujiwara, M. Masutani, M. Tachibana, N. Okada   +3 more
semanticscholar   +1 more source

Intratumoral Delivery of a PD-1–Blocking scFv Encoded in Oncolytic HSV-1 Promotes Antitumor Immunity and Synergizes with TIGIT Blockade

Cancer immunology research, 2020
Oncolytic virus activity is often limited by an immunosuppressive tumor microenvironment. The antitumor efficacy of oncolytic herpes simplex virus is improved by delivering a single-chain variable fragment specific for PD-1.
Chaolong Lin, Wenfeng Ren, Yong Luo, Shaopeng Li, Yating Chang, Lu Li, D. Xiong, Xiaoxuan Huang, Zilong Xu, Zeng Yu, Yingbing Wang, Jun Zhang, Chenghao Huang, N. Xia   +13 more
semanticscholar   +1 more source

Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo

Nature Biotechnology, 2018
The efficacy of chimeric antigen receptor (CAR) T cell therapy against poorly responding tumors can be enhanced by administering the cells in combination with immune checkpoint blockade inhibitors.
S. Rafiq, O. Yeku, H. J. Jackson, Terence J. Purdon, Dayenne G van Leeuwen, Dylan J Drakes, Mei Song, Matthew M. Miele, Zhuoning Li, Pei Wang, Su Yan, Jingyi Xiang, Xiaojing Ma, V. Seshan, R. Hendrickson, Cheng Liu, R. Brentjens   +16 more
semanticscholar   +1 more source

Anti-PEG scFv corona ameliorates accelerated blood clearance phenomenon of PEGylated nanomedicines.

Journal of Controlled Release, 2020
Anti-PEG antibodies have been witnessed in patients and experimental animals, accelerating the blood clearance (termed ABC phenomenon) of PEGylated nanomedicines by activating complement after absorption on the nano-surface.
Zui Zhang, Yuxiu Chu, Cheng Li, Wenjing Tang, Jun Qian, Xiaoli Wei, Weiyue Lu, T. Ying, Changyou Zhan   +8 more
semanticscholar   +1 more source

Expression of Sclerostin scFv and the Effect of Sclerostin scFv on Healing of Osteoporotic Femur Fracture in Rats

Cell Biochemistry and Biophysics, 2013
Osteoporosis is a systemic metabolic disease characterized by low bone mass with deterioration of the bony microstructure which leads to both bone brittleness and increased risk of fracture. Sclerostin is a protein encoded by the SOST gene which is specifically expressed in osteocyte.
Qi, Yao, Jie, Ni, Yu, Hou, Lixiang, Ding, Licheng, Zhang, Hua, Jiang   +5 more
openaire   +2 more sources

A T-cell–engaging B7-H4/CD3-bispecific Fab-scFv Antibody Targets Human Breast Cancer

Clinical Cancer Research, 2019
Purpose: The B7 homolog 4 (B7-H4, VTCN1) is an immune checkpoint molecule that negatively regulates immune responses and is known to be overexpressed in many human cancers.
A. Iizuka, C. Nonomura, T. Ashizawa, Ryota Kondou, K. Ohshima, T. Sugino, K. Mitsuya, N. Hayashi, Y. Nakasu, K. Maruyama, K. Yamaguchi, Y. Akiyama   +11 more
semanticscholar   +1 more source

Reformatting of scFv Antibodies into the scFv-Fc Format and Their Downstream Purification

2014
The scFv-Fc format allows for rapid characterization of candidate scFvs isolated from phage display libraries before conversion into a full-length IgG. This format offers several advantages over the phage display-derived scFv, including bivalent binding, longer half-life, and Fc-mediated effector functions.
Emil, Bujak, Mattia, Matasci, Dario, Neri, Sarah, Wulhfard   +3 more
openaire   +2 more sources