Results 1 to 10 of about 502,506 (259)
AAV2/8 Anti-angiogenic Gene Therapy Using Single-Chain Antibodies Inhibits Murine Choroidal Neovascularization [PDF]
Molecular Therapy: Methods & Clinical Development, 2019 While anti-angiogenic therapies for wet age-related macular degeneration (AMD) are effective for many patients, they require multiple injections and are expensive and prone to complications.
Chris P. Hughes +8 more
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Advancement in the development of single chain antibodies using phage display technology [PDF]
PeerJPhage display technology has become an important research tool in biological research, fundamentally changing the traditional monoclonal antibody preparation process, and has been widely used in the establishment of antigen-antibody libraries, drug ...
Xiaohui Zheng +6 more
doaj +3 more sources
Camelid‐derived single‐chain antibodies in hemostasis: Mechanistic, diagnostic, and therapeutic applications [PDF]
Research and Practice in Thrombosis and Haemostasis, 2020 Hemostasis is a complex process involving the concerted action of molecular and vascular components. Its basic understanding as well as diagnostic and therapeutic aspects have greatly benefited from the use of monoclonal antibodies.
Ivan Peyron +8 more
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Neurobiology of Disease, 2004 A library of phage-displayed human single-chain Fv (scFv) antibodies was selected against the human amyloid-beta peptide (Aβ42). Two new anti-Aβ42 phage-displayed scFvs antibodies were obtained, and the sequences of their VH and Vκ genes were analyzed. A
K. Manoutcharian +10 more
doaj +3 more sources
A VHH-Based Anti-MUC1 Chimeric Antigen Receptor For Specific Retargeting Of Human Primary T Cells To MUC1-Positive Cancer Cells [PDF]
Cell Journal, 2021 Objective: Immunotherapy with redirected T cells that express a chimeric antigen receptor (CAR) is a promising prospect in cancer treatment. Most CARs use murine-derived single-chain variable fragments (scFvs) as an antigen targeting moiety, which may ...
Alireza Rajabzadeh +4 more
doaj +1 more source
Affinity Chromatography of Native and Recombinant Proteins from Receptors for Insulin and IGF-I to Recombinant Single Chain Antibodies. [PDF]
Front Endocrinol (Lausanne), 2015 Fujita-Yamaguchi Y.
europepmc +2 more sources
Scientific Reports, 2021 The high binding affinities and specificities of antibodies have led to their use as drugs and biosensors. Single-domain VHH antibodies exhibit high specificity and affinity but have higher stability and solubility than conventional antibodies as they ...
Emina Ikeuchi +4 more
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Frontiers in Immunology, 2022 A subset of antibodies found in cattle comprises ultralong CDR-H3 regions of up to 70 amino acids. Interestingly, this type of immunoglobulin usually pairs with the single germline VL gene, V30 that is typically very conserved in sequence.
Daniel Klewinghaus +6 more
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Antibodies, 2022 Monoclonal antibodies have been used successfully as recombinant protein therapy; however, for HIV, multiple broadly neutralizing antibodies may be necessary.
Elisabeth Narayanan +7 more
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Structural Biology of Nanobodies against the Spike Protein of SARS-CoV-2
Viruses, 2021 Nanobodies are 130 amino acid single-domain antibodies (VHH) derived from the unique heavy-chain-only subclass of Camelid immunogloblins. Their small molecular size, facile expression, high affinity and stability have combined to make them unique ...
Qilong Tang +2 more
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