Results 221 to 230 of about 52,178 (281)

Retraction Note: Superparamagnetic iron oxide nanoparticles conjugated with Aβ oligomer-specific ScFv antibody and class A scavenger receptor activator show therapeutic potentials for alzheimer's disease. [PDF]

J Nanobiotechnology
Liu XG, Zhang L, Lu S, Liu DQ, Huang YR, Zhu J, Zhou WW, Yu XL, Liu RT.   +8 more
europepmc   +1 more source

Structure-guided design of antibody CDRs to reduce their reactivity to treatment-emergent anti-drug antibodies. [PDF]

MAbs
Johansson MU, Kerschenmeyer A, Carella A, Carnal S, Schmidt Y, de Felice A, Mahler D, Thomas M, Spiga FM, Tietz J, Weinert C, Hess C, Urech D, Warmuth S.   +13 more
europepmc   +1 more source

Engineered extracellular vesicles-mediated curcumin delivery in brain microenvironment modulating lysosomes, mitochondria, and microglia reprogram for parkinson's disease therapy. [PDF]

J Nanobiotechnology
Shie MY, Chen MC, Chen Y, Huang SW, Lin YH, Yu MH, Pan CM, Chen CY, Chen YW, Hsieh CL, Chiu SC, Kao ST, Lin JG, Cho DY.   +13 more
europepmc   +1 more source

Deciphering Protein Corona by scFv-Based Affinity Chromatography

Nano Letters, 2021
It remains challenging to precisely decipher the structural and functional characteristics of protein coronas. To overcome the drawbacks frequently occurring in the traditional separation methods, an anti-PEG single-chain variable fragment (PEG-scFv ...
Cheng Li, Xiaoli Wei, Tianlei Ying
exaly   +5 more sources

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ScFv Improvement Approaches.

Protein & Peptide Letters, 2018
The most common recombinant antibody format is the single chain fragment variable (scFv) which it contains the complete antigen-binding domains of an intact antibody. ScFv fragments have found vast medical and non-medical applications. Several approaches have been employed to increase the affinity, avidity and structural stability related to these ...
Peyman Bemani, Mozafar Mohammadi, Ali Hakakian   +2 more
semanticscholar   +3 more sources

Rapid, Point-of-Care scFv-SERS Assay for Femtogram Level Detection of SARS-CoV-2

ACS Sensors, 2022
Rapid, sensitive, on-site identification of SARS-CoV-2 infections is an important tool in the control and management of COVID-19. We have developed a surface-enhanced Raman scattering (SERS) immunoassay for highly sensitive detection of SARS-CoV-2 ...
Patrick Alfred Johnson, J Gerard Wall
exaly   +2 more sources

Tuning the ignition of CAR: optimizing the affinity of scFv to improve CAR-T therapy

Cellular and Molecular Life Sciences, 2021
Chan Liao, Yong-Min Tang, Chun Zhou
exaly   +2 more sources

Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo

Nature Biotechnology, 2018
The efficacy of chimeric antigen receptor (CAR) T cell therapy against poorly responding tumors can be enhanced by administering the cells in combination with immune checkpoint blockade inhibitors.
Sarwish Rafiq, Dayenne G Van Leeuwen, Mei Song   +2 more
exaly   +2 more sources

Interdomain spacing and spatial configuration drive the potency of IgG-[L]-scFv T cell bispecific antibodies

Science Translational Medicine, 2020
T cell–bispecific antibody antitumor function is maximized through optimal interdomain spacing and dual cis-configurations. The specifics of bispecifics T cell–bispecific antibodies, which are designed to bring T cells together with tumor cells and ...
Brian H Santich, Jeong A Park, Morgan Huse   +2 more
exaly   +2 more sources