Results 181 to 190 of about 2,730 (205)

Schisandrin B and Schisandrol B induce mouse CYP2b10 associated with CAR not PXR

Phytochemistry Letters, 2020
Abstract Schisandrin B (SinB) and Schisandrol B (SolB) are two abundant compounds with similar structures in Schisandra sphenanthera widely used for hepatic diseases in Asian countries. They are also pharmacologically active components in many other traditional Chinese medicines.
Minzhu Xie, Jiao Lin, Jinyu Kang, Xiuting Zheng, Kailu Fang, Yishuang Luo, Aiming Liu, Julin Yang   +7 more
openaire   +1 more source

Schisandrin B suppresses TGFβ1 signaling by inhibiting Smad2/3 and MAPK pathways

Biochemical Pharmacology, 2012
TGFβ1 plays a crucial role in the pathogenesis of vascular fibrotic diseases. Schisandra chinensis (S. chinensis), which is used as an oriental herbal medicine, is effective in the treatment of vascular injuries that cause aberrant TGFβ1 signaling. In this study, we investigated whether S.
Eun-Jung, Park, Jung Nyeo, Chun, Su-Hwa, Kim, Chul Young, Kim, Hee Ju, Lee, Hye Kyung, Kim, Jong Kwan, Park, Sung Won, Lee, Insuk, So, Ju-Hong, Jeon   +9 more
openaire   +2 more sources

Antioxidant effect of schisandrin B in nervous tissue

2014
Fructus schisandrae (FS), the fruit of Schisandra chinensis, has been used as tonic and sedative in traditional Chinese medicine. Previous studies from our laboratory have demonstrated that schisandrin B (Sch B), a dibenzocyclooctadiene derivative isolated from FS, could produce antioxidant effect on rodent liver and heart.
openaire   +2 more sources

[Schisandrin B prevents doxorubicin-induced cardiotoxicity in rabbits].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2011
To study the effect of dexrazoxane in preventing doxorubicin-induced cardiotoxicity in rabbit-models and its mechanism.Thirty one New Zealand white rabbits were randomly divided into two groups, doxorubicin (DOX) group and doxorubicin + dexrazoxane group.
Fei-Fei, Che, Yu, Liu, Cai-Gang, Xu
openaire   +1 more source

Preclinical Concomitant Toxicokinetic Study of Schisandrin B by HPLC–MS/MS

Biomedical Chromatography
ABSTRACTSchisandrin B (Sch B), a natural lignan extracted from schisandra chinesis, has exhibited various pharmacological activities including anticancer effects. However, studies on the preclinical toxicokinetic profile of Sch B have not been publicly reported.
Sanwen Li, Qing Shao, Hongqun Qiao
openaire   +2 more sources

Schisandrin B attenuates renal fibrosis via miR-30e-mediated inhibition of EMT

Toxicology and Applied Pharmacology, 2019
Tubulointerstitial fibrosis (TIF) is the main pathologic feature of end-stage renal disease. Epithelial-mesenchymal transition (EMT) of proximal tubular cells (PTCs) is one of the most significant features of TIF. MicroRNAs play critical roles during EMT in TIF.
Guangxu Cao, Shuang Li, Hezhan Shi, Peidi Yin, Jialing Chen, Huifeng Li, Ying Zhong, Li-Ting Diao, Bin Du   +8 more
openaire   +2 more sources

Exploring the Protective Effects of Schisandrin A and Schisandrin B Against Diabetic Cardiomyopathy With a Possible Mechanism Involving Complement Inhibition

Phytotherapy Research
ABSTRACTSchisandra berry, an edible fruit of the Schisandra genus, produces two main lignans known as Schisandrin A (SchA) and Schisandrin B (SchB). These compounds have garnered significant attention for their beneficial effects in alleviating diabetes and its complications, such as diabetic nephropathy and diabetic neuropathy.
Daozheng Fang, Qixiang Shang, Zhihao Liu, Xinyue Li, Quanrun He, Yining Liu, Yong Zhu, Haimeng Li, Tong Wu, Yan‐Fang Xian, Jianping Chen, Jihang Chen   +11 more
openaire   +2 more sources

Schisandrin C improves leaky gut conditions in intestinal cell monolayer, organoid, and nematode models by increasing tight junction protein expression

Phytomedicine, 2022
Mi Ri Kim, UYEN NGUYEN TRAN TU, Ki Young Choi   +2 more
exaly  

Schisandrin ameliorates cognitive deficits, endoplasmic reticulum stress and neuroinflammation in streptozotocin (STZ)-induced Alzheimer’s disease rats

Experimental Animals, 2020
Lifen Yao
exaly  

A review: Pharmacology and pharmacokinetics of Schisandrin A

Phytotherapy Research, 2022
Cheng Wang, Lihong Gong, Yun-Xia Li
exaly