Results 21 to 30 of about 27,508 (229)
Mechanism of assembly of snRNP cores assisted by ICln and the SMN complex in fission yeast
iScience, 2023 Summary: The spliceosomal snRNP cores, each comprised of a snRNA and a seven-membered Sm ring (D1/D2/F/E/G/D3/B), are assembled by twelve chaperoning proteins in human.
Yan Hu +7 more
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Vacuolar protein sorting receptor in Schizosaccharomyces pombe [PDF]
Microbiology, 2006 The mechanism by which soluble proteins, such as carboxypeptidase Y, reach the vacuole inSaccharomyces cerevisiaeis very similar to the mechanism of lysosomal protein sorting in mammalian cells. Vps10p is a receptor for transport of soluble vacuolar proteins inS. cerevisiae.vps10+, a gene encoding a homologue ofS.
Tomoko, Iwaki +7 more
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Elementary Protein Analysis in Schizosaccharomyces pombe [PDF]
Cold Spring Harbor Protocols, 2017 Biochemical monitoring and interrogation of protein function is a critical component of most fission yeast studies. In particular, its small proteome size, high conservation of core molecular cell biology, and genetic malleability make Schizosaccharomyces pombe an excellent model organism in which to use mass spectrometry to conduct proteome-wide ...
Agnes, Grallert, Iain M, Hagan
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STAR Protocols, 2022 Summary: Many cellular processes require the activities of complex molecular machines composed of several protein subunits. Insights into these systems can be gained by isolation of protein complexes followed by in vitro analyses determining the identity,
Lubos Cipak +7 more
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PLoS ONE, 2021 In spite of increased complexity in eukaryotes compared to prokaryotes, several basic metabolic and regulatory processes are conserved. Here we explored analogies in the eubacteria Escherichia coli and the unicellular fission yeast Schizosaccharomyces ...
Joivier Vichi +7 more
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The Schizosaccharomyces pombe Hsp104 disaggregase is unable to propagate the [PSI] prion. [PDF]
PLoS ONE, 2009 The molecular chaperone Hsp104 is a crucial factor in the acquisition of thermotolerance in yeast. Under stress conditions, the disaggregase activity of Hsp104 facilitates the reactivation of misfolded proteins. Hsp104 is also involved in the propagation
Patrick Sénéchal +4 more
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DNA-protein interactions at the telomeric repeats of Schizosaccharomyces pombe [PDF]
Nucleic Acids Research, 1996 Gel retardation assays using a probe containing the repeat region of a Schizosaccharomyces pombe chromosomal telomere identified four specific DNA- protein complexes in S. pombe total protein extracts (I, I', IIa and IIb). The proteins responsible for these complexes bound to the telomeric repeat region irrespective of whether or not the repeats were ...
M, Duffy, A, Chambers
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The Multiple Functions of Rho GTPases in Fission Yeasts
Cells, 2021 The Rho family of GTPases represents highly conserved molecular switches involved in a plethora of physiological processes. Fission yeast Schizosaccharomyces pombe has become a fundamental model organism to study the functions of Rho GTPases over the ...
Jero Vicente-Soler +4 more
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A novel DNA damage recognition protein in Schizosaccharomyces pombe [PDF]
Nucleic Acids Research, 2006 Toxic and mutagenic O6-alkylguanine adducts in DNA are repaired by O6-alkylguanine-DNA alkyltransferases (MGMT) by transfer of the alkyl group to a cysteine residue in the active site. Comparisons in silico of prokaryotes and lower eukaryotes reveal the presence of a group of proteins [alkyltransferase-like (ATL) proteins] showing amino acid sequence ...
Pearson SJ +9 more
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mBio, 2016 Proteins containing polyglutamine (polyQ) regions are found in almost all eukaryotes, albeit with various frequencies. In humans, proteins such as huntingtin (Htt) with abnormally expanded polyQ regions cause neurodegenerative diseases such as Huntington’
Ashley A. Zurawel +8 more
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