Results 41 to 50 of about 672,718 (247)

The “tricky business” of dual use school community libraries: A case study in rural South Africa [PDF]

open access: yes, 2011
The article describes an interpretive case study of a group of six dual use school community libraries in one remote region of South Africa. Its focus is rather more on the libraries as school libraries than public libraries.
Hart, Genevieve
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Transforming education in a rural ecosystem: school libraries as hubs for teaching-learning innovation

open access: yesFrontiers in Education
IntroductionAlthough literature shows that libraries can play a significant role in student learning, very little is known about how the availability of libraries can transform rural education ecosystems.
Lulama Mdodana-Zide, Godsend T. Chimbi
doaj   +1 more source

Subject description of non-fiction literature for adults: expert-theoretical basis for the realisation of the »Hidden Treasure« research project

open access: yesKnjižnica, 2004
Library users searching through non-fiction library material by subject in online OPACs, expect to be able to search fiction by subject as well. The research project Skriti zaklad (Hidden Treasure) was launched in 2002 and was aimed at improving the ...
Andrej Pogorelec   +4 more
doaj   +1 more source

Lining Up The P\u27s [PDF]

open access: yes, 2006
This presentation addresses four aspects of marketing and is applicable to academic, special, school and public ...
Fisher, Pat, Pride, Marcy M
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

The litany of suffering is still heard but not louder : a case study of clinical supervision to school libraries in Indonesia’s four provinces [PDF]

open access: yes, 2005
From 2002 through 2004, the National Library of Indonesia distributed block grants to 250 school libraries in the province of Central Java scattered in 10 districts, 150 school libraries in West Nusa Tenggara for 7 districts, 125 school libraries ...
Sulistyo-Basuki, L.
core  

Leveraging new knowledge with relational capabilities: an investigation of rural school libraries in southern Portugal [PDF]

open access: yes, 2016
Purpose: This paper aims to identify and conceptualize a set of relational capabilities that school libraries in the Alentejo region of Portugal develop for acquiring new knowledge that exists externally in the wider community.
Canhoto, R., Martins, J.T.
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

School libraries Pathfinders

open access: yesIranian Journal of Information Processing & Management, 2009
School library represents one of the important locations suited for offering reference services. The skill set necessary in order to use information resources, is called information literacy. When discussing information literacy and means of enhancing it,
Shideh Taleban
doaj  

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