mTORC1 is essential for early steps during Schwann cell differentiation of amniotic fluid stem cells and regulates lipogenic gene expression. [PDF]
PLoS ONE, 2014 Schwann cell development is hallmarked by the induction of a lipogenic profile. Here we used amniotic fluid stem (AFS) cells and focused on the mechanisms occurring during early steps of differentiation along the Schwann cell lineage.
Andrea Preitschopf +13 more
doaj +14 more sources
Engineered Neural Tissue (EngNT) Containing Human iPSC-Derived Schwann Cell Precursors Promotes Axon Growth in a Rat Model of Peripheral Nerve Injury [PDF]
BioengineeringTissue engineering has the potential to overcome the limitations of using autografts in nerve gap repair, using cellular biomaterials to bridge the gap and support neuronal regeneration.
Rebecca A. Powell +6 more
doaj +2 more sources
Schwann cell Lrp1 deletion drives trigeminal neuron sensitization and orofacial pain by modulating mitochondrial function and TRPV1/TRPA1 activity. [PDF]
J Headache PainGong Z +7 more
europepmc +2 more sources
The Effect of Schwann Cells/Schwann Cell-Like Cells on Cell Therapy for Peripheral Neuropathy
Frontiers in Cellular Neuroscience, 2022 Peripheral neuropathy is a common neurological issue that leads to sensory and motor disorders. Over time, the treatment for peripheral neuropathy has primarily focused on medications for specific symptoms and surgical techniques.
Qian Wang +8 more
doaj +1 more source
Acta Biológica Colombiana, 2004 The neurones are the cells of the nervous system and are surrounded and protected by glials cells. In the peripheral nervous system the Schwann cells (SC) are the glia of the nerves.
Sandra Perdomo, Clara Spinel
doaj +1 more source
Frontiers in Cellular Neuroscience, 2021 Embryonic Dissociated Dorsal Root Ganglia (DRG) cultures are often used to investigate the role of novel molecular pathways or drugs in Schwann cell development and myelination.
Venkat Krishnan Sundaram +7 more
doaj +1 more source
Schwann-spheres derived from injured peripheral nerves in adult mice--their in vitro characterization and therapeutic potential. [PDF]
PLoS ONE, 2011 Multipotent somatic stem cells have been identified in various adult tissues. However, the stem/progenitor cells of the peripheral nerves have been isolated only from fetal tissues.
Takehiko Takagi +10 more
doaj +1 more source
Biochemistry and Biophysics Reports, 2023 Bell's palsy is the most common form of facial nerve palsy. This study aimed to explore the pathogenesis of Bell's palsy by investigating the effect of cold-stimulated adipocyte supernatant on adhesion molecule expression in Schwann cell line.
Tiefeng Zhang +6 more
doaj +1 more source
Denervated Schwann cells attract macrophages by secretion of leukemia inhibitory factor (LIF) and monocyte chemoattractant protein-1 in a process regulated by interleukin-6 and LIF [PDF]
, 2002 Injury to peripheral nerves results in the infiltration of immune cells, which remove axonal- and myelin-derived material. Schwann cells could play a key role in this process by regulating macrophage infiltration.
Jessen, KR +3 more
core +2 more sources
Inhibition of Schwann Cell Pyroptosis Promotes Nerve Regeneration in Peripheral Nerve Injury in Rats
Mediators of Inflammation, 2023 Background. Peripheral nerve injury (PNI) is one of the most debilitating injuries, but therapies for PNI are still far from satisfactory. Pyroptosis, a recently identified form of cell death, has been demonstrated to participate in different diseases ...
Jiayi Wang +9 more
doaj +1 more source