Results 101 to 110 of about 128,417 (336)
European Journal of Neurology, Volume 30, Issue 2, Page 511-526, February 2023., 2023 Abstract Background and purpose Charcot–Marie–Tooth disease (CMT) is a heterogeneous group of disorders caused by mutations in at least 100 genes. However, approximately 60% of cases with axonal neuropathies (CMT2) still remain without a genetic diagnosis. We aimed at identifying novel disease genes responsible for CMT2.
Silvia Cipriani +23 more
wiley +1 more source
Stem Cell Reports, 2017 Schwann cells play a crucial role in successful nerve repair and regeneration by supporting both axonal growth and myelination. However, the sources of human Schwann cells are limited both for studies of Schwann cell development and biology and for the ...
Han-Seop Kim +7 more
doaj +1 more source
Ras/Raf signalling in primary cells [PDF]
, 2002 Oncogenic activation of the Ras gene has been implicated in many human tumours. However, despite the ability of Ras to transform immortal cell lines, activated Ras is growth inhibitory in primary cells. We have previously shown that activation of Ras/Raf
Harrisingh, Marie
core
A Dual Role of erbB2 in Myelination and in Expansion of the Schwann Cell Precursor Pool [PDF]
, 2000 Neuregulin-1 provides an important axonally derived signal for the survival and growth of developing Schwann cells, which is transmitted by the ErbB2/ErbB3 receptor tyrosine kinases.
Adlkofer +72 more
core +3 more sources
Implantable Self‐Powered Systems for Electrical Stimulation Medical Devices
Advanced Science, EarlyView.In this paper, the design strategy and clinical application of ISS are discussed in depth from four aspects: the design and optimization of the energy collection module, the selection and preparation of adaptive electrode materials, the innovation of system design strategy, and the biological effect of electrical stimulation of ISS.
Xi Cui, Li Wu, Chao Zhang, Zhou Li
wiley +1 more source
F1000Research, 2013 Background: Bacterial pathogens can manipulate or subvert host tissue cells to their advantage at different stages during infection, from initial colonization in primary host niches to dissemination. Recently, we have shown that Mycobacterium leprae (ML),
Toshihiro Masaki +4 more
doaj +1 more source
Nlrp6 promotes recovery after peripheral nerve injury independently of inflammasomes [PDF]
, 2015 Background: NOD-like receptors (Nlrs) are key regulators of immune responses during infection and autoimmunity. A subset of Nlrs assembles inflammasomes, molecular platforms that are activated in response to endogenous danger and microbial ligands and ...
De Winter, Vicky +6 more
core +2 more sources
Advanced Science, EarlyView.Inspired by exercise‐induced metabolic rewiring and EV secretion, this study shows that in vivo metabolic engineering strategy can reprogram EV secretion pattern and simultaneously attenuate multiple tissue injury in CKD status, highlighting that it is a potential strategy for treating diverse chronic diseases.
Meng Zhao +11 more
wiley +1 more source
Histopathology, Volume 82, Issue 2, Page 254-263, January 2023., 2023 The introduction of bowel cancer population screening programs has had a profound impact on gastrointestinal pathology. While the focus is mainly on quality assurance of diagnoses relevant for the outcome of these programs (colorectal cancer and its precursors), incidental findings are increasingly diagnosed.
Iris D Nagtegaal +4 more
wiley +1 more source
TRPV4 activation in Schwann cells mediates mechanically induced pain of oral cancer
Frontiers in Pain ResearchIntroductionPatients with oral cancer often experience intense functional pain due to mechanical stimulation at the cancer site. The role of mechanosensitive ion channels in oral cancer pain, such as TRPV4, is not fully understood.ObjectivesOur objective
Yatendra Mulpuri +26 more
doaj +1 more source