Results 11 to 20 of about 49,600 (309)
Schwann cells in regeneration and cancer
Frontiers in PharmacologySchwann cells are specific peripheral glial cells with remarkable plasticity following peripheral nerve injury. Injury responses stimulate c-Jun activation in Schwann cells, drive epithelial-mesenchymal transition and cellular phenotypic changes, and ...
Lan Zhang +4 more
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The immunocompetence of Schwann cells [PDF]
Muscle & Nerve, 2007 AbstractSchwann cells are the myelinating glial cells of the peripheral nervous system that support and ensheath axons with myelin to enable rapid saltatory signal propagation in the axon. Immunocompetence, however, has only recently been recognized as an important feature of Schwann cells.
Gerd Meyer zu Hörste +4 more
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Schwann cells and trigeminal neuralgia [PDF]
Molecular Pain, 2020 Schwann cells are components of the peripheral nerve myelin sheath, which supports and nourishes axons. Upon injury of the trigeminal nerve, Schwann cells are activated and cause trigeminal neuralgia by engulfing the myelin sheath and secreting various neurotrophic factors.
Jia-Yi Liao +3 more
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Embryonic Schwann cell development: the biology of Schwann cell precursors and early Schwann cells
Journal of Anatomy, 1997 The cellular events leading to the generation of Schwann cells from the neural crest have recently been clarified and it is now possible to outline a relatively simple model of the Schwann cell lineage in the rat and mouse. Neural crest cells have to undergo 3 main developmental transitions to become mature Schwann cells.
Kristjan R. Jessen, Rhona Mirsky
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Myelinophagy: Schwann cells dine in [PDF]
Journal of Cell Biology, 2015 When nerve injury occurs, the axon and myelin fragments distal to the injury site have to be cleared away before repair. In this issue, Gomez-Sanchez et al. (2015; J. Cell Biol. http://dx.doi.org/10.1083/jcb.201503019) find that clearance of the damaged myelin within Schwann cells occurs not by phagocytosis but rather via selective autophagy, in a ...
Mikael Simons +2 more
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Directly induced human Schwann cell precursors as a valuable source of Schwann cells [PDF]
Stem Cell Research & Therapy, 2020 AbstractBackgroundSchwann cells (SCs) are primarily responsible for regeneration and repair of the peripheral nervous system (PNS). Renewable and lineage-restricted SC precursors (SCPs) are considered highly desirable and promising cell sources for the production of SCs and for studies of SC lineage development, but SCPs are extremely limited. Here, we
Han-Seop Kim +4 more
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PLoS ONE, 2021 Introduction Polyneuropathy is a debilitating condition characterized by distal sensory and motor deficits. Schwann cell dysfunction and axonal loss are integral factors in pathophysiology and disease progression of polyneuropathy.
Eva Placheta-Györi +4 more
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Dabrafenib Promotes Schwann Cell Differentiation by Inhibition of the MEK-ERK Pathway
Molecules, 2021 Schwann cell differentiation involves a dynamic interaction of signaling cascades. However, much remains to be elucidated regarding the function of signaling molecules that differ depending on the context in which the molecules are engaged.
Kyuhee Park +4 more
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Integrative study of Arabidopsis thaliana metabolomic and transcriptomic data with the interactive MarVis-Graph software [PDF]
PeerJ, 2014 State of the art high-throughput technologies allow comprehensive experimental studies of organism metabolism and induce the need for a convenient presentation of large heterogeneous datasets.
Manuel Landesfeind +6 more
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Mining Gene Ontology Data with AGENDA
Bioinformatics and Biology Insights, 2012 The Gene Ontology (GO) initiative is a collaborative effort that uses controlled vocabularies for annotating genetic information. We here present AGENDA ( A pplication for mining Gen e Ontology Da ta), a novel web-based tool for accessing the GO database.
Guvanch Ovezmyradov +2 more
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