Results 11 to 20 of about 128,417 (336)
The immunocompetence of Schwann cells [PDF]
Muscle & Nerve, 2007 AbstractSchwann cells are the myelinating glial cells of the peripheral nervous system that support and ensheath axons with myelin to enable rapid saltatory signal propagation in the axon. Immunocompetence, however, has only recently been recognized as an important feature of Schwann cells.
Gerd Meyer zu Hörste +4 more
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Schwann cells and trigeminal neuralgia [PDF]
Molecular Pain, 2020 Schwann cells are components of the peripheral nerve myelin sheath, which supports and nourishes axons. Upon injury of the trigeminal nerve, Schwann cells are activated and cause trigeminal neuralgia by engulfing the myelin sheath and secreting various neurotrophic factors.
Jia-Yi Liao +3 more
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Directly induced human Schwann cell precursors as a valuable source of Schwann cells [PDF]
Stem Cell Research & Therapy, 2020 AbstractBackgroundSchwann cells (SCs) are primarily responsible for regeneration and repair of the peripheral nervous system (PNS). Renewable and lineage-restricted SC precursors (SCPs) are considered highly desirable and promising cell sources for the production of SCs and for studies of SC lineage development, but SCPs are extremely limited. Here, we
Han-Seop Kim +4 more
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Dabrafenib Promotes Schwann Cell Differentiation by Inhibition of the MEK-ERK Pathway
Molecules, 2021 Schwann cell differentiation involves a dynamic interaction of signaling cascades. However, much remains to be elucidated regarding the function of signaling molecules that differ depending on the context in which the molecules are engaged.
Kyuhee Park +4 more
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PLoS ONE, 2021 Introduction Polyneuropathy is a debilitating condition characterized by distal sensory and motor deficits. Schwann cell dysfunction and axonal loss are integral factors in pathophysiology and disease progression of polyneuropathy.
Eva Placheta-Györi +4 more
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PLoS ONE, 2020 Transference of RNAs and ribosomes from Schwann cell-to-axon was demonstrated in normal and regenerating peripheral nerves. Previously, we have shown that RNAs transfer is dependent on F-actin cytoskeleton and Myosin Va.
Lucía Canclini +6 more
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Molecular Medicine, 2021 Background Growth factors execute essential biological functions and affect various physiological and pathological processes, including peripheral nerve repair and regeneration.
Yaxian Wang +7 more
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Embryonic Schwann cell development: the biology of Schwann cell precursors and early Schwann cells
Journal of Anatomy, 1997 The cellular events leading to the generation of Schwann cells from the neural crest have recently been clarified and it is now possible to outline a relatively simple model of the Schwann cell lineage in the rat and mouse. Neural crest cells have to undergo 3 main developmental transitions to become mature Schwann cells.
Kristjan R. Jessen, Rhona Mirsky
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Myelinophagy: Schwann cells dine in [PDF]
Journal of Cell Biology, 2015 When nerve injury occurs, the axon and myelin fragments distal to the injury site have to be cleared away before repair. In this issue, Gomez-Sanchez et al. (2015; J. Cell Biol. http://dx.doi.org/10.1083/jcb.201503019) find that clearance of the damaged myelin within Schwann cells occurs not by phagocytosis but rather via selective autophagy, in a ...
Mikael Simons +2 more
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FGF/heparin differentially regulates Schwann cell and olfactory ensheathing cell interactions with astrocytes: a role in astrocytosis [PDF]
, 2007 After injury, the CNS undergoes an astrocyte stress response characterized by reactive astrocytosis/proliferation, boundary formation, and increased glial fibrillary acidic protein (GFAP) and chondroitin sulfate proteoglycan (CSPG) expression. Previously,
Barnett, S.C. +7 more
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