Results 41 to 50 of about 128,417 (336)
Emergence of collective propulsion through cell-cell adhesion [PDF]
Phys. Rev. E 97, 042413 (2018), 2017 The mechanisms driving the collective movement of cells remain poorly understood. To contribute toward resolving this mystery, a model was formulated to theoretically explore the possible functions of polarized cell-cell adhesion in collective cell migration. The model consists of an amoeba cell with polarized cell-cell adhesion, which is controlled by
arxiv +1 more source
A Comprehensive and Detailed Within-Host Modeling Study involving crucial Bio markers and Optimal Drug regimen for Lepra Type-I Reaction : A Deterministic Approach [PDF]
arXiv, 2022 Leprosy (Hansen's disease) is an infectious, neglected tropical disease caused by the Mycobacterium Leprae (M. Leprae). Each year there are approximately 2,02,189 new cases are detected globally. In the year 2017 more than half million people were disabled due to leprosy and almost 50000 new cases are added every year world wide.
arxiv
A cell membrane model that reproduces cortical flow-driven cell migration and collective movement [PDF]
, 2023 Many fundamental biological processes are dependent on cellular migration. Although the mechanical mechanisms of single-cell migration are relatively well understood, those underlying migration of multiple cells adhered to each other in a cluster, referred to as cluster migration, are poorly understood.
arxiv +1 more source
Schwann cell dysfunction in uraemia [PDF]
Journal of Neurology, Neurosurgery & Psychiatry, 1970 Examination of individual sural nerve fibres revealed segmental demyelination, in 10 out of 12 subjects with uraemia. Peripheral neuropathy was present in only two cases. The complex biochemical changes occurring with dialysis unmask the underlying demyelination in subjects with a latent neuropathy.
J. J. Dinn, D. L. Crane
openaire +3 more sources
Myelination: all about Rac n roll. [PDF]
, 2007 During the development of the peripheral nervous system, Schwann cells select individual axons from a nerve bundle and establish a one-to-one relationship through a process termed radial sorting. Recent findings identify the Rho family GTPase Rac1 as the
Chan, Jonah
core +2 more sources
Neural Regeneration Research, 2016 MicroRNAs (miRNAs) are small, non-coding RNAs that negatively adjust gene expression in multifarious biological processes. However, the regulatory effects of miRNAs on Schwann cells remain poorly understood.
Tian-mei Qian +9 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2021 Peripheral nerve injuries arising from trauma or disease can lead to sensory and motor deficits and neuropathic pain. Despite the purported ability of the peripheral nerve to self-repair, lifelong disability is common. New molecular and cellular insights
Anjali Balakrishnan +10 more
doaj +1 more source
A physical perspective to understand myelin. II. The physical origin of myelin development [PDF]
arXiv, 2021 The physical principle of myelin development is obtained from our previous study by explaining Peter's quadrant mystery: an external applied negative and positive E-field can promote and inhibit the growth of the inner tongue of the myelin sheath, respectively. In this study, this principle is considered as a fundamental hypothesis, named Hypothesis-E,
arxiv
Notch and Schwann cell transformation [PDF]
Oncogene, 2004 Benign plexiform neurofibromas in NF1 patients can transform spontaneously into malignant peripheral nerve sheath tumors (MPNSTs). Although mutations in the p53 gene have been found in a subset of MPNSTs and mouse models support a role for p53 mutations in malignant conversion, we found that each of three Schwann cell lines derived from human MPNSTs ...
Peggy Wallace +9 more
openaire +3 more sources
Expression and localization of Ski determine cell type–specific TGFβ signaling effects on the cell cycle [PDF]
, 2008 Transforming growth factor β (TGFβ) promotes epithelial cell differentiation but induces Schwann cell proliferation. We show that the protooncogene Ski (Sloan-Kettering viral oncogene homologue) is an important regulator of these effects.
Atanasoski, Suzana +3 more
core +2 more sources