Results 41 to 50 of about 49,600 (309)

Practical Guide to the Design of Granular Hydrogels for Customizing Complex Cellular Microenvironments

Advanced Healthcare Materials, EarlyView.
Granular hydrogels are emerging microporous platforms for cell culture and delivery, showing great potential for replicating the complex, heterogeneous environments found in natural tissues. This review outlines the design principles of granular hydrogels, highlighting critical factors that determine the final physicochemical properties of the entire ...
Shuhan Feng, Kaiyang Chen, Shiqi Wang
wiley   +1 more source

Schwann cell dysfunction in uraemia [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 1970
Examination of individual sural nerve fibres revealed segmental demyelination, in 10 out of 12 subjects with uraemia. Peripheral neuropathy was present in only two cases. The complex biochemical changes occurring with dialysis unmask the underlying demyelination in subjects with a latent neuropathy.
J. J. Dinn, D. L. Crane
openaire   +3 more sources

Porous Decellularized Nerve Grafts Facilitate Recellularization and Nerve Regeneration in a Rat Model of Critical Long‐Gap Peripheral Nerve Injury

Advanced Healthcare Materials, EarlyView.
A decellularized nerve graft (DNG) is modified to generate a porous DNG (PDNG). The PDNG is used to repair a 30‐mm peripheral nerve injury (PNI) defect, and is compared with isograft, serving as the standard, and DNG, a widely used alternative. The result shows that PDNG facilitated nerve regeneration in long‐gap PNI, evidenced by better‐aligned axonal
Olawale Alimi Alimi, Mitchell Kuss, Wen Xue, Bo Liu, Mena Asha Krishnan, Tianshu Pan, Zhi He, Han‐Jun Wang, Yuguo Lei, Kai Yang, Bin Duan   +10 more
wiley   +1 more source

Data on the effect of in vivo knockdown using artificial ErbB3 miRNA on Remak bundle structure

Data in Brief, 2017
Mature Schwann cells, the peripheral nervous system (PNS) glial cells, have two major roles for neuronal axons (Bunge, 1993) [1]. For large diameter axons, Schwann cells form myelin sheaths with multiple layers.
Yuki Miyamoto, Tomohiro Torii, Kazuko Kawahara, Masashi Inoue, Takako Morimoto, Masahiro Yamamoto, Junji Yamauchi   +6 more
doaj   +1 more source

Wireless Acousto‐Piezoelectric Conduit with Aligned Nanofibers for Neural Regeneration

Advanced Materials, EarlyView.
An ultrasound‐driven, highly aligned piezoelectric nanofiber‐based nerve guidance conduit (APNF‐NGC) designed for effective peripheral nerve repair has been demonstrated in this study. Featuring aligned topology, cell‐adhesive surfaces, and an axial electric field, the APNF‐NGC collectively promotes significant nerve regeneration.
Sera Jeon, Dabin Kim, Min‐Young Jo, Chae‐Min Ryu, Daniel Sanghyun Cho, Byung‐Ok Choi, Jae Kwang Kim, Miso Kim, Sang‐Woo Kim   +8 more
wiley   +1 more source

TNFα mediates Schwann cell death by upregulating p75NTR expression without sustained activation of NFκB

Neurobiology of Disease, 2005
Administration of tumour necrosis factor α (TNFα) to axotomised mouse neonatal sciatic nerves increased Schwann cell apoptosis in the distal nerve segments, 5-fold greater than axotomy alone.
Kristy Boyle, Michael F. Azari, Surindar S. Cheema, Steven Petratos   +3 more
doaj   +1 more source

Stimuli‐Responsive Materials for Biomedical Applications

Advanced Materials, EarlyView.
Stimulus‐responsive materials (SRMs) hold great promise for use in a wide range of biomedical applications. This review covers four stimulus modalities, namely, electrical, optical, magnetic, and ultrasound, and their associated SRMs. It provides a summary of the materials in each modality, their development, and current research perspectives.
Adriana Teixeira do Nascimento, Paul R. Stoddart, Toon Goris, Miriam Kael, Richard Manasseh, Karen Alt, Jurie Tashkandi, Byung Chul Kim, Simon E Moulton   +8 more
wiley   +1 more source

Reprogramming diminishes retention of Mycobacterium leprae in Schwann cells and elevates bacterial transfer property to fibroblasts [v2; ref status: indexed, http://f1000r.es/280]

F1000Research, 2013
Background: Bacterial pathogens can manipulate or subvert host tissue cells to their advantage at different stages during infection, from initial colonization in primary host niches to dissemination. Recently, we have shown that Mycobacterium leprae (ML),
Toshihiro Masaki, Aidan McGlinchey, Simon R. Tomlinson, Jinrong Qu, Anura Rambukkana   +4 more
doaj   +1 more source

TNFα promotes oral cancer growth, pain, and Schwann cell activation

Scientific Reports, 2021
Oral cancer is very painful and impairs a patient’s ability to eat, talk, and drink. Mediators secreted from oral cancer can excite and sensitize sensory neurons inducing pain.
Elizabeth Salvo, Nguyen H. Tu, Nicole N. Scheff, Zinaida A. Dubeykovskaya, Shruti A. Chavan, Bradley E. Aouizerat, Yi Ye   +6 more
doaj   +1 more source

3D Printing for Neural Repair: Bridging the Gap in Regenerative Medicine

Advanced Materials, EarlyView.
This perspective article discusses how 3D bioprinting is advancing the development of neural tissue models and implants. It highlights recent progress in fabricating complex, multicellular neural constructs, examines current technical barriers, and outlines future applications in disease modeling, neurotoxicity testing, and regenerative therapies ...
Mitchell St Clair‐Glover, Zhilian Yue, Mirella Dottori   +2 more
wiley   +1 more source