Results 11 to 20 of about 51,731 (281)
The immunocompetence of Schwann cells [PDF]
Muscle & Nerve, 2007 AbstractSchwann cells are the myelinating glial cells of the peripheral nervous system that support and ensheath axons with myelin to enable rapid saltatory signal propagation in the axon. Immunocompetence, however, has only recently been recognized as an important feature of Schwann cells.
Gerd Meyer zu Hörste +4 more
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Schwann cells and trigeminal neuralgia [PDF]
Molecular Pain, 2020 Schwann cells are components of the peripheral nerve myelin sheath, which supports and nourishes axons. Upon injury of the trigeminal nerve, Schwann cells are activated and cause trigeminal neuralgia by engulfing the myelin sheath and secreting various neurotrophic factors.
Jia-Yi Liao +3 more
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SOX10 transactivates S100B to suppress Schwann cell proliferation and to promote myelination. [PDF]
PLoS ONE, 2014 Schwann cells are an important cell source for regenerative therapy for neural disorders. We investigated the role of the transcription factor sex determining region Y (SRY)-box 10 (SOX10) in the proliferation and myelination of Schwann cells.
Sayaka Fujiwara +9 more
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Embryonic Schwann cell development: the biology of Schwann cell precursors and early Schwann cells
Journal of Anatomy, 1997 The cellular events leading to the generation of Schwann cells from the neural crest have recently been clarified and it is now possible to outline a relatively simple model of the Schwann cell lineage in the rat and mouse. Neural crest cells have to undergo 3 main developmental transitions to become mature Schwann cells.
Kristjan R. Jessen, Rhona Mirsky
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Contribution of Schwann Cells to Remyelination in a Naturally Occurring Canine Model of CNS Neuroinflammation. [PDF]
PLoS ONE, 2015 Gliogenesis under pathophysiological conditions is of particular clinical relevance since it may provide evidence for regeneration promoting cells recruitable for therapeutic purposes.
Kristel Kegler +5 more
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Myelinophagy: Schwann cells dine in [PDF]
Journal of Cell Biology, 2015 When nerve injury occurs, the axon and myelin fragments distal to the injury site have to be cleared away before repair. In this issue, Gomez-Sanchez et al. (2015; J. Cell Biol. http://dx.doi.org/10.1083/jcb.201503019) find that clearance of the damaged myelin within Schwann cells occurs not by phagocytosis but rather via selective autophagy, in a ...
Mikael Simons +2 more
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Directly induced human Schwann cell precursors as a valuable source of Schwann cells [PDF]
Stem Cell Research & Therapy, 2020 AbstractBackgroundSchwann cells (SCs) are primarily responsible for regeneration and repair of the peripheral nervous system (PNS). Renewable and lineage-restricted SC precursors (SCPs) are considered highly desirable and promising cell sources for the production of SCs and for studies of SC lineage development, but SCPs are extremely limited. Here, we
Han-Seop Kim +4 more
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Journal of Nanobiotechnology, 2022 Background Schwann cells, the glial cells in the peripheral nervous system, are highly plastic. In response to nerve injury, Schwann cells are reprogrammed to a series of specialized repair-promoting phenotypes, known as repair Schwann cells, which play ...
Ting Liu, Yang Wang, Laijin Lu, Yi Liu
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Schwann Cell Myelination [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 Myelinated nerve fibers are essential for the rapid propagation of action potentials by saltatory conduction. They form as the result of reciprocal interactions between axons and Schwann cells. Extrinsic signals from the axon, and the extracellular matrix, drive Schwann cells to adopt a myelinating fate, whereas myelination reorganizes the axon for its
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Long non-coding RNA NONMMUG014387 promotes Schwann cell proliferation after peripheral nerve injury
Neural Regeneration Research, 2017 Schwann cells play a critical role in peripheral nerve regeneration through dedifferentiation and proliferation. In a previous study, we performed microarray analysis of the sciatic nerve after injury.
Bin Pan +4 more
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