FGF/heparin differentially regulates Schwann cell and olfactory ensheathing cell interactions with astrocytes: a role in astrocytosis [PDF]
, 2007 After injury, the CNS undergoes an astrocyte stress response characterized by reactive astrocytosis/proliferation, boundary formation, and increased glial fibrillary acidic protein (GFAP) and chondroitin sulfate proteoglycan (CSPG) expression. Previously,
Barnett, S.C. +7 more
core +3 more sources
TNFα promotes oral cancer growth, pain, and Schwann cell activation
Scientific Reports, 2021 Oral cancer is very painful and impairs a patient’s ability to eat, talk, and drink. Mediators secreted from oral cancer can excite and sensitize sensory neurons inducing pain.
Elizabeth Salvo +6 more
doaj +1 more source
Glial βii spectrin contributes to paranode formation and maintenance [PDF]
, 2018 Action potential conduction along myelinated axons depends on high densities of voltage-gated Na channels at the nodes of Ranvier. Flanking each node, paranodal junctions (paranodes) are formed between axons and Schwann cells in the peripheral nervous ...
Benusa, Savannah D. +12 more
core +1 more source
Inhibition of Schwann Cell Pyroptosis Promotes Nerve Regeneration in Peripheral Nerve Injury in Rats
Mediators of Inflammation, 2023 Background. Peripheral nerve injury (PNI) is one of the most debilitating injuries, but therapies for PNI are still far from satisfactory. Pyroptosis, a recently identified form of cell death, has been demonstrated to participate in different diseases ...
Jiayi Wang +9 more
doaj +1 more source
Autophagy is involved in the reduction of myelinating Schwann cell cytoplasm during myelin maturation of the peripheral nerve. [PDF]
PLoS ONE, 2015 Peripheral nerve myelination involves dynamic changes in Schwann cell morphology and membrane structure. Recent studies have demonstrated that autophagy regulates organelle biogenesis and plasma membrane dynamics.
So Young Jang +7 more
doaj +1 more source
Ribosomal trafficking is reduced in Schwann cells following induction of myelination. [PDF]
, 2015 Local synthesis of proteins within the Schwann cell periphery is extremely important for efficient process extension and myelination, when cells undergo dramatic changes in polarity and geometry.
Love, James M, Shah, Sameer B
core +2 more sources
Lithium promotes proliferation and suppresses migration of Schwann cells
Neural Regeneration Research, 2020 Schwann cell proliferation, migration and remyelination of regenerating axons contribute to regeneration after peripheral nervous system injury. Lithium promotes remyelination by Schwann cells and improves peripheral nerve regeneration.
Xiao-Kun Gu +3 more
doaj +1 more source
Gpr126/Adgrg6 has Schwann cell autonomous and nonautonomous functions in peripheral nerve injury and repair [PDF]
, 2016 Schwann cells (SCs) are essential for proper peripheral nerve development and repair, although the mechanisms regulating these processes are incompletely understood.
Carlin, Dan +8 more
core +2 more sources
Cell Transplantation, 2013 Olfactory mucosa (OM)-derived olfactory ensheathing cells (OECs) are attractive candidates for autologous cell transplantation-based therapy of nervous system injury.
Susanne Ziege +2 more
doaj +1 more source
Rab27a/Slp2-a complex is involved in Schwann cell myelination
Neural Regeneration Research, 2016 Myelination of Schwann cells in the peripheral nervous system is an intricate process involving myelin protein trafficking. Recently, the role and mechanism of the endosomal/lysosomal system in myelin formation were emphasized.
Wen-feng Su +7 more
doaj +1 more source