Results 51 to 60 of about 855,880 (342)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Self-effective scientific reasoning? Differences between elementary and secondary school students

Frontline Learning Research, 2022
Although scientific reasoning is not a formal, independent school subject, it is an increasingly important skill, especially for student learning in science, technology, engineering, and mathematics (STEM) subjects.
Kristin Nyberg, Susanne Koerber, Christopher Osterhaus   +2 more
doaj   +1 more source

PENERAPAN PENDEKATAN LEVELS OF INQUIRY UNTUK MENINGKATKAN SCIENTIFIC REASONING SISWA SMP PADA MATERI KALOR [PDF]

, 2014
Hasil observasi menunjukkan bahwa kemampuan bernalar secara ilmiah atau scientific reasoning merupakan kemampuan yang kurang terfasilitasi dalam proses pembelajaran fisika di kelas.
Maryanti, Maya
core  

Geospatial Narratives and their Spatio-Temporal Dynamics: Commonsense Reasoning for High-level Analyses in Geographic Information Systems

, 2013
The modelling, analysis, and visualisation of dynamic geospatial phenomena has been identified as a key developmental challenge for next-generation Geographic Information Systems (GIS).
Bhatt, Mehul, Wallgruen, Jan Oliver
core   +2 more sources

Engaging astronomy students online with scientific reasoning about real data [PDF]

, 2022
Jeffrey Hyde
openalex   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Unraveling research: Understanding scientific reasoning

Bangabandhu Sheikh Mujib Medical University Journal
Not ...
Tanvir C Turin, Mohammad M H Raihan, Nashit A Chowdhury   +2 more
doaj   +1 more source

The Case of Dinosaur Metabolism [PDF]

, 2017
In lieu of an abstract, here is the article\u27s first paragraph: To learn the critical skill of scientific argumentation, students need learning experiences that involve constructing evidence-based explanations.
Llewellyn, Douglas, Ullock, Caitlin
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source