Results 71 to 80 of about 116,865 (301)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
IDENTIFICATION OF SCIENTIFIC REASONING ABILITY OF JUNIOR HIGH SCHOOL STUDENTS
Jurnal EdusciencePurpose – This study aims to 1) identify the level of scientific reasoning ability and 2) the difference between indicators of scientific reasoning ability of male and female junior high school students in Samarinda on climate change.
Etrica Damayanti Wulandari +4 more
doaj +1 more source
The Emergence of Scientific Reasoning [PDF]
, 2012 Scientific reasoning encompasses the reasoning and problem-solving skills involved in generating, testing and revising hypotheses or theories, and in the case of fully developed skills, reflecting on the process of knowledge acquisition and knowledge change that results from such inquiry activities.
Bradley J. +3 more
openaire +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
, 2008 PhDAlthough human causal reasoning is widely acknowledged as an object of scientific enquiry, there is little consensus on an appropriate measure of progress.
Brandano, Sergio, Sergio Brandano
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Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Studia PsychologicaThe main aim of our study was to investigate whether COVID-19 conspiracy beliefs are driven by a lack of useful and potentially protective mindware or by contaminated mindware.
Viktória Sunyik, Vladimíra Čavojová
doaj +1 more source
A Philosophical Treatise on the Connection of Scientific Reasoning with Fuzzy Logic
Mathematics, 2020 The present article studies the connection of scientific reasoning with fuzzy logic. Induction and deduction are the two main types of human reasoning.
Evangelos Athanassopoulos +1 more
doaj +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source