Results 61 to 70 of about 6,123,967 (287)

Towards LarKC: a Platform forWeb-scale Reasoning [PDF]

, 2008
Current Semantic Web reasoning systems do not scale to the requirements of their hottest applications, such as analyzing data from millions of mobile devices, dealing with terabytes of scientific data, and content management in enterprises with thousands
Andersson, B., Florian Fischer, Andersson, Bo, Cunningham, Hamish, Kyung-il Lee, T., Schooler, Lael, Fensel, D., Michael Witbrock, Huang, Zhisheng, Paul Brennan, Stefan Wesner, Huang, Z., Kiryakov, Atanas, Tresp, Volker, Van Harmelen, Frank, Lee, Tony Kyung Il, Witbrock, M., Cunningham, H., Schooler, L., Zhisheng Huang, Wesner, S., Ning Zhong, Della Valle, E, Emanuele Della Valle, Van Harmelen, Frank; id_orcid, Tony Kyung-il Lee, Dieter Fensel, Fischer, F., Lael Schooler, van Harmelen, F., Zhong, Ning, Atanas Kiryakov, Brennan, Paul, Witbrock, Michael, Volker Tresp, della Valle, E., Brennan, P., Fischer, Florian, Frank van Harmelen, Valle, Emanuele Delia, Kiryakov, A., Bo Andersson, Lee, Tony, Tresp, V., Fensel, Dieter, Wesner, Stefan, Hamish Cunningham, Zhong, N.   +47 more
core   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

COGNITIVE DEVELOPMENT AND VARIABLE CONTROL IN SCIENTIFIC REASONING: ASSESSING INDONESIAN STUDENTS' ENVIRONMENTAL CHANGE UNDERSTANDING VIA LAWSON CLASSROOM TEST

Jurnal Nalar Pendidikan
This study aims to assess the scientific reasoning abilities of Class XI IPA students at SMA Negeri 3 Gorontalo in relation to environmental change materials. The background of this study is based on the low scientific reasoning skills of students, which
Nurul Fajryani Usman, Nur Mustaqimah, Herinda Mardin   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Latent profile analysis of schizotypy, autistic traits and conspiracy theory beliefs: Associations with cognitive flexibility and scientific reasoning performance

Journal of Experimental Psychopathology, 2022
Schizotypal and autistic traits have both been implicated in the development of conspiracy theory (CT) beliefs. However, there are both similarities and differences between these traits that may increase an individual’s susceptibility to CT beliefs. Past
Neophytos Georgiou, Paul Delfabbro, Ryan Balzan   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Developing and validating a multi-tiered instrument for assessing knowledge and reasoning about socioscientific issues

Disciplinary and Interdisciplinary Science Education Research
Today’s information-rich societies increasingly require citizens to evaluate scientific claims that carry social, ethical, and political consequences.
Janelle M. Bailey, Melike Hanedar, Gale M. Sinatra, Carla McAuliffe, Eric C. Schoute, Kristen Brighter   +5 more
doaj   +1 more source

SCIENTIFIC REASONING ABILITY OF HIGH SCHOOL STUDENTS IN PALANGKA RAYA IN PHYSICS LEARNING

Jurnal Eduscience
Purpose-Scientific reasoning is an essential ability in learning science, including physics. This study aims to assess the scientific reasoning abilities of high school students in Palangka Raya City, focusing on six indicators: conservation reasoning ...
Pri Ariadi Cahya Dinata, Rensi Lukas, Theo Jhoni Hartanto, Desy Kumala Sari   +3 more
doaj   +1 more source