Results 61 to 70 of about 449,463 (258)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
مجلة الدراسات الاجتماعيةThis study investigated the challenges faced by translator trainees in translating scientific and technical texts between Arabic and English. A mixed-methods approach was utilized for this purpose.
Sameer Hameed Ahmed Saeed
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Decoy Nanoparticles and Protein Corona Modulation: A Novel Frontier in Sepsis Treatment
International Journal of NanomedicineEvgeniya R Denisova,1 Darya S Volkova,1 Valeria V Streltsova,1 Stepan A Kopytov,1 Artem S Krivosheev,1 Elizaveta V Panfilova,1 Neng Yan,2 Dmitry Kostyushev,3– 6 Mazdak Ganjalikhani-Hakemi,7 Vadim S Pokrovsky,8,9 Manu Lopus,10 Andrey V Golovin,1,6 Andrey ...
Denisova ER +14 more
doaj
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Hypoxia in Breast Cancer-Scientific Translation to Therapeutic and Diagnostic Clinical Applications. [PDF]
Front Oncol, 2021 Zhang Y +9 more
europepmc +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Дискурс профессиональной коммуникацииCommenting on translations of scientific texts is part of metatranslation activity. Studies in this field traditionally involve analysing translation techniques, tactics and strategies explicitly presented in paratextual elements.
D. S. Zolotukhin
doaj +1 more source