Results 91 to 100 of about 25,148 (309)
Journal of the Endocrine Society, 2022 Parathyroid hormone (PTH) increases fibroblast growth factor 23 (FGF23), mediated both by protein kinase A (PKA) and Wnt signaling, and decreases expression of sclerostin, a Wnt antagonist derived from osteocytes.
Yuki Nagata +6 more
semanticscholar +1 more source
Circulating levels of sclerostin are associated with cardiovascular mortality. [PDF]
PLoS ONE, 2018 Cardiovascular diseases are a health problem throughout the world, especially in people with diabetes. The identification of cardiovascular disease biomarkers can improve risk stratification.
Cristina Novo-Rodríguez +8 more
doaj +1 more source
Recent Developments in Osteogenesis Imperfecta [PDF]
, 2015 Osteogenesis imperfecta (OI) is an uncommon genetic bone disease associated with brittle bones and fractures in children and adults. Although OI is most commonly associated with mutations of the genes for type I collagen, many other genes (some ...
Albert, Carolyne +3 more
core +2 more sources
Advanced Science, EarlyView.We report an electrochemical biosensor that employs biopanning‐derived affinity peptides as selective receptors on a multifunctional chitosan–zwitterionic–gold nanoparticle (CS–ZI–AuNPs) nanohydrogel interface. The CS–ZI–AuNPs nanohydrogel exhibits antifouling properties, abundant sites for stable peptide immobilization, and efficient electrochemical ...
Hyo Jeong Yang +6 more
wiley +1 more source
International Journal of Endocrinology, 2014 Objectives. Sclerostin, an osteocyte-specific protein, has been found to be related to adiposity and glucose metabolism. Irisin, a myokine, can affect browning of white fat and influence glucose and energy homeostasis.
Theerawut Klangjareonchai +7 more
doaj +1 more source
Sclerostin does not play a major role in the pathogenesis of skeletal complications in type 2 diabetes mellitus [PDF]
, 2016 Summary: In contrast to previously reported elevations in serum sclerostin levels in diabetic patients, the present study shows that the impaired bone microarchitecture and cellular turnover associated with type 2 diabetes mellitus (T2DM)-like conditions
A. Hvid +10 more
core +7 more sources
The Anatomical Record, EarlyView.Abstract The vertebrate skull is composed of bones derived from neural crest cells and mesoderm. The evolutionary capacity of the skull has been linked, in part, to the emergence of neural crest cells; however, this increased capacity for evolutionary change requires that variation within neural crest‐ and mesoderm‐derived bones remains partly ...
Alyssa C. Moore +5 more
wiley +1 more source
Bone, 2021 The peroxisome proliferator activated receptor gamma (PPARG) nuclear receptor regulates energy metabolism and insulin sensitivity. In this study, we present novel evidence for an essential role of PPARG in the regulation of osteocyte function, and ...
S. Baroi +4 more
semanticscholar +1 more source
The Effect of Renal Dysfunction on Circulating Sclerostin Level in Patients with Type 2 Diabetes
International Journal of Endocrinology, 2014 Objective. Sclerostin is a Wnt inhibitor produced specifically by osteocytes. However, it is not currently clear whether renal dysfunction has an effect on circulating sclerostin level in patients with type 2 diabetes.
Se Hwa Kim +3 more
doaj +1 more source
Synaptic plasticity and cognitive function are disrupted in the absence of Lrp4. [PDF]
, 2014 Lrp4, the muscle receptor for neuronal Agrin, is expressed in the hippocampus and areas involved in cognition. The function of Lrp4 in the brain, however, is unknown, as Lrp4-/- mice fail to form neuromuscular synapses and die at birth.
Burden, Steven J +2 more
core +1 more source