Results 91 to 100 of about 20,344 (273)

The Role of Wnt Signaling in Age‐Related Alveolar Bone Loss and Regeneration

Journal of Periodontal Research, EarlyView.
The graphical abstract summarizes key signaling pathways involved in bone formation and resorption associated with Wnt signaling across young and aged long bone and jaw tissues. Levels of evidence are indicated as robust, moderate, or emerging, reflecting the current experimental support in each context.
Hsiao H. Sung, Navya Chalamalasetty, Ali Alzainal, Hanlong Liu, Lexuan Wang, Pietra Colacrai Arikita, Ivy C. X. Wei, Hom‐Lay Wang, M. H. J. van den Bosch, Michelle S. Caird, Peter M. van der Kraan, Kenneth M. Kozloff, Esmeralda Blaney Davidson   +12 more
wiley   +1 more source

Recent Progress in Osteocyte Research [PDF]

, 2013
The last decade has seen an exponential increase in our understanding of osteocytes function and biology. These cells, once considered inert by-standers trapped into the mineralized bone, has now risen to be key regulators of skeletal metabolism, mineral
Divieti Pajevic, Paola
core   +2 more sources

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

Sclerostin Promotes Bone Remodeling in the Process of Tooth Movement. [PDF]

PLoS ONE, 2017
Tooth movement is a biological process of bone remodeling induced by mechanical force. Sclerostin secreted by osteocytes is mechanosensory and important in bone remodeling. However, little is known regarding the role of sclerostin in tooth movement.
Rui Shu, Ding Bai, Tzongjen Sheu, Yao He, Xianrui Yang, Chaoran Xue, Yiruo He, Mengyuan Zhao, Xianglong Han   +8 more
doaj   +1 more source

Role of key players in paradigm shifts of prostate cancer bone metastasis [PDF]

, 2018
Prostate cancer is one of the most common human cancers and bone metastasis is a frequent finding in the natural history of several types of cancers. The molecular mechanisms that makes prostate cancer metastasize to bone have recently been identified, and
Beg, OA, Butt, SI, Iqbal, S, Javed, S, Li, Z, Sherin, L, Sohail, A   +6 more
core   +2 more sources

Molecular pathophysiology of chronic kidney disease–mineral and bone disorder: Focus on the fibroblast growth factor 23–Klotho axis and bone turnover dynamics

Experimental Physiology, EarlyView.
Abstract Chronic kidney disease–mineral and bone disorder (CKD‐MBD) is a major complication of chronic kidney disease (CKD), characterized by disruptions in mineral metabolism, abnormal bone turnover and vascular calcification, which collectively increase the risk of fractures and cardiovascular disease.
Alief Waitupu, Laras Pratiwi, Henry Sutanto, Djoko Santoso, Decsa Medika Hertanto   +4 more
wiley   +1 more source

Sclerostin Blood Levels Before and After Kidney Transplantation

Kidney & Blood Pressure Research, 2014
Background/Aims: Sclerostin is secreted by osteocytes. As a circulating inhibitor of the Wnt-signaling pathway it inhibits bone formation and contributes to the development of osteoporosis.
Marco Bonani, Daniel Rodriguez, Thomas Fehr, Nilufar Mohebbi, Jens Brockmann, Markus Blum, Nicole Graf, Diana Frey, Rudolf P. Wüthrich   +8 more
doaj   +1 more source

LRP4+ Astrocytes: A Unique Subpopulation Crucial for Blood Vessel Maintenance and Function in the Somatosensory Cortex of Normal and 5xFAD Mice

Glia, Volume 74, Issue 2, February 2026.
Lrp4+ astrocytes, uniquely vessel‐associated and GFAP−, are enriched in the pia. They support laminin‐α5+ basement membrane assembly and regulate vessel diameter and blood flow. They are reduced in 5xFAD brains, and their ablation worsens both vascular and Aβ pathology.
Emily Arzola, Gefei Yu, Lei Xiong, Daehoon Lee, Anika Wu, Shriya Paruchuri, Jasmine Skinner, Minghui Wang, Bin Zhang, Lin Mei, Wen‐Cheng Xiong   +10 more
wiley   +1 more source

Positive and Negative Regulators of Sclerostin Expression [PDF]

, 2022
Rina Iwamoto, Masanori Koide, Nobuyuki Udagawa, Yasuhiro Kobayashi   +3 more
openalex   +1 more source

Genetic variation in Wnt/β-catenin and ER signalling pathways in female and male elite dancers and its associations with low bone mineral density: a cross-section and longitudinal study. [PDF]

, 2018
The association of genetic polymorphisms with low bone mineral density in elite athletes have not been considered previously. The present study found that bone mass phenotypes in elite and pre-elite dancers are related to genetic variants at the Wnt/β ...
A Guadalupe-Grau, A Liedert, A Nattiv, A Nott, A. D. Flouris, AF Doyle-Lucas, AS Brazeau, C George, C Kesavan, C. Durães, DG Monroe, DG Winkler, E Twitchett, EA Twitchett, EM Kirchner, F. Marques, G. S. Metsios, H Li, IP Braidman, J Delgado-Calle, J Majewski, J Xu, J. C. Machado, J. Maia, JC Gibbs, JH Tobias, JP Bonjour, K Lee, KJ Jepsen, KL Scofield, KM Khan, L Maïmoun, L Maïmoun, L Pietro Di, L. Nogueira, LF Bonewald, LF Bonewald, M Mountjoy, M Suuriniemi, M-SM Ardawi, M. Wyon, MK Torstveit, N a Georgopoulos, N Pollock, N. Adubeiro, P Burckhardt, PB Crawford, PS Hinton, R Valentino, RW Kleposki, S Wheatley, T Amorim, T Amorim, T Amorim, T. Amorim, TL Robinson, W Xing, WF Li, X Tu, Y. Koutedakis   +59 more
core   +2 more sources