Results 101 to 110 of about 25,148 (309)

Romosozumab and Denosumab Combination Therapy After Denosumab in Postmenopausal Osteoporosis

Arthritis &Rheumatology, EarlyView.
Objective Transition from long‐term denosumab (Dmab) to parathyroid hormone‐analogs or romosozumab (Romo) might expose patients to the risk of the so‐called rebound phenomenon. Adding Romo to Dmab might represent an option in patients experiencing a fracture while on Dmab.
Giovanni Adami, Francesco Pollastri, Angelo Fassio, Filippo Montanari, Anna Piccinelli, Camilla Benini, Emma Pasetto, Carmen Dartizio, Davide Gatti, Maurizio Rossini, Ombretta Viapiana   +10 more
wiley   +1 more source

Sclerostin: Current Knowledge and Future Perspectives [PDF]

Calcified Tissue International, 2010
In recent years study of rare human bone disorders has led to the identification of important signaling pathways that regulate bone formation. Such diseases include the bone sclerosing dysplasias sclerosteosis and van Buchem disease, which are due to deficiency of sclerostin, a protein secreted by osteocytes that inhibits bone formation by osteoblasts.
Moester, M.J.C., Papapoulos, S.E., Lowik, C.W.G.M., Bezooijen, R.L. van   +3 more
openaire   +3 more sources

Anti-sclerostin antibody – A potential therapeutic target for periodontal bone regeneration

Journal of Oral Research and Review
Sclerostin is a glycoprotein predominantly released by specialized bone-forming cells (osteocytes). It serves as a principal inhibitor of osteogenesis and plays a key act in modulating the metabolism of alveolar bone. Sclerostin is shown to contribute to
Shruthi Reghunath, Roshni Ramesh, Raseena Beevi Nafeesa, Divya Purushothaman Visalakshy, Binitta Paul Kannappillil, Ambili Gopalakrishnan   +5 more
doaj   +1 more source

Sclerostin Quo Vadis? - Is This a Useful Long-Term Mortality Parameter in Prevalent Hemodialysis Patients?

Kidney & Blood Pressure Research, 2015
Background/Aims: Cardiovascular calcification contributes to the increased mortality in hemodialysis patients. Sclerostin was identified as an antianabolic bone factor causing soft tissue calcification. Data on prospective large-scale studies associating
Albina Nowak, Ferruh Artunc, Andreas L. Serra, Emily Pollock, Pierre-Alexandre Krayenbühl, Christian Müller, Björn Friedrich   +6 more
doaj   +1 more source

Detection of early osteogenic commitment in primary cells using Raman spectroscopy [PDF]

, 2017
Major challenges in the development of novel implant surfaces for artificial joints include osteoblast heterogeneity and the lack of a simple and sensitive in vitro assay to measure early osteogenic responses.
Clarkin, C E, Emery, R, Mahajan, S, Pitsillides, A A, Smith, S J   +4 more
core   +1 more source

Dextran sodium sulfate confounds causal role of periodontitis in inflammatory bowel disease

Journal of Periodontology, EarlyView.
Abstract Background Emerging evidence supports a bidirectional link between periodontitis and inflammatory bowel disease (IBD). To investigate this relationship, experimental models commonly use dextran sodium sulfate (DSS) to induce colitis. However, DSS is presumed to selectively affect the colon, and its potential off‐target effects on the oral ...
Himanshi Tanwar, Jeba Mercy Gnanasekaran, Niyant Ganesh, Cindy Zhou, Amy Plotkin, Giacomo Baima, Massimo Costalonga, Fenfen Zhou, Hanping Feng, Priyam Jani, Jean‐Pierre Raufman, Vivek Thumbigere‐Math   +11 more
wiley   +1 more source

Sclerostin levels during growth in children [PDF]

Osteoporosis International, 2011
Serum sclerostin levels are associated with cortical porosity, suggesting that changes in sclerostin production during growth may play a role in defining cortical structure.Sclerostin, produced by osteocytes, is a potent inhibitor of Wnt signaling and bone formation.
Kirmani, Salman, Amin, S., McCready, L. K., J. Atkinson, E. J., Melton, L. Joseph, III, Müller, R., Khosla, S.   +6 more
openaire   +2 more sources

Serum sclerostin and sympathetic skin response: relationship with myeloma bone disease

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 2022
Background Myeloma bone disease (MBD) is a common complication that significantly contributes to morbidity and mortality in multiple myeloma (MM). Serum sclerostin level and sympathetic activity can affect MBD.
Alaa A. Omran, Rania S. Nageeb, Ahmad Barakat Waley, Ghada S. Nageeb, Mohamad Eisa   +4 more
doaj   +1 more source

Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mouse model of hereditary hemochromatosis [PDF]

, 2018
Osteoporosis is associated with chronic iron overload secondary to hereditary hemochromatosis (HH), but the causative mechanisms are incompletely understood.
Camacho, António, Cancela, M. Leonor, Cohen-Solal, Martine, Hang Korng, Ea, Ostertag, Agnès, Pinto, I. Jorge, Porto, Graça, Simão, Márcio   +7 more
core   +4 more sources

Cyotoxicity of Etidronate as an Endodontic Chelator Against Periodontal Ligament Fibroblast

Australian Endodontic Journal, EarlyView.
ABSTRACT Etidronic acid (HEBP) causes fewer alterations in dentine and can be used mixed with sodium hypochlorite during root canal preparation. This study investigated the cytotoxicity effects of the HEDP and EDTA on human periodontal ligament fibroblast cells. Primary culture was established from human periodontal ligament tissue of one donor and was
Bruno Vila Nova de Almeida, Patrícia de Almeida Rodrigues, Geovanni Pereira Mitre, Maria Sueli da Silva Kataoka, João de Jesus Viana Pinheiro, Talita Tartari, Oscar Faciola Pessoa   +6 more
wiley   +1 more source