Results 101 to 110 of about 20,344 (273)

Rosuvastatin in Combination With Bortezomib Promotes Osteogenesis in Myeloma Bone Disease by Inhibiting the Secretion of CCL3

eJHaem, Volume 7, Issue 1, February 2026.
ABSTRACT Background Myeloma bone disease (MBD) is a devastating complication of multiple myeloma (MM) and a primary cause of disability in affected patients. Its pathogenesis is driven by an imbalance in bone remodeling, largely attributed to the overexpression of C‐C motif chemokine ligand 3 (CCL3). While both bortezomib and statins have been reported
Fujun Qu, Mingxu Hui, Fan Yang, Bo Huang, Nian Liu, Yuchan He, Xiaotao Wang   +6 more
wiley   +1 more source

Generation and characterization of two immortalized human osteoblastic cell lines useful for epigenetic studies [PDF]

, 2017
Different model systems using osteoblastic cell lines have been developed to help understand the process of bone formation. Here, we report the establishment of two human osteoblastic cell lines obtained from primary cultures upon transduction of ...
A Eddleston, AL Boskey, AR Shakoori, C Lipps, C Rentsch, Carolina Sañudo, CI Westacott, CM Cowan, D Benayahu, D Vanderschueren, Flor M. Pérez-Campo, G Jones, H Ishida, H Sudo, H Tullberg-Reinert, J Delgado-Calle, J Delgado-Calle, J Delgado-Calle, J Delgado-Calle, Jana Arozamena, Jeannette Zauers, Jesús Delgado-Calle, JN Beresford, José A. Riancho, JP Leeuwen van, LG Rao, María T. Berciano, MH Mankani, MH Mankani, Miguel Lafarga, MK Sutherland, MM Wong, MP Whyte, N Maruotti, NK Lee, PV Bodine, SA Harris, SA Stewart, SB Rodan, SH Scharla, T Matsumoto, TJ Shaw, TL Chen, Tobias May, U Valentiner, X Li, Y Suzuki   +46 more
core   +2 more sources

Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen, Binghua Li, Shengjia Wang, Yongzhong Yao, Zhao Huang, Decai Yu   +5 more
wiley   +1 more source

Sclerostin and Its Involvement in the Pathogenesis of Idiopathic Scoliosis [PDF]

, 2021
Elias Vasiliadis, Dimitrios Stergios Evangelopoulos, Angelos Kaspiris, Christos Vlachos, Spyros G Pneumaticos   +4 more
openalex   +1 more source

Osteocyte-Driven Bone Remodeling [PDF]

, 2013
Osteocytes, the most abundant cells in bone, have been long postulated to detect and respond to mechanical and hormonal stimuli and to coordinate the function of osteoblasts and osteoclasts.
Bellido, Teresita
core   +1 more source

Vibration‐Mediated Recovery of Irradiated Osteocytes and Their Regulatory Role in Breast Cancer Bone Metastasis

Advanced Healthcare Materials, Volume 15, Issue 4, 26 January 2026.
Radiotherapy damages bone and disrupts osteocyte function, yet mechanically mediated protection remains largely unexplored. This study demonstrates that low‐magnitude, high‐frequency (LMHF) vibration mitigates irradiated osteocyte apoptosis, restores their ability to regulate breast cancer extravasation, and acts synergistically with radiotherapy to ...
Xin Song, Kimberly Seaman, Amel Sassi, Chun‐Yu Lin, Tiankuo Chu, Liyun Wang, Yu Sun, Lidan You   +7 more
wiley   +1 more source

Sclerostin and Wnt Signaling in Idiopathic Juvenile Osteoporosis Using High-Resolution Confocal Microscopy for Three-Dimensional Analyses

Children
Background: Idiopathic juvenile osteoporosis (IJO) is a rare condition characterized by low bone mass that can increase the risk of fractures in children.
Renata C. Pereira, Kathleen J. Noche, Barbara Gales, Zhangying Chen, Isidro B. Salusky, Lauren V. Albrecht   +5 more
doaj   +1 more source

Co-expression of DKK-1 and Sclerostin in Subchondral Bone of the Proximal Femoral Heads from Osteoarthritic Hips [PDF]

, 2017
Osteoarthritis (OA) is a progressively degenerative joint disease influenced by structural and metabolic factors. There is growing evidence that subchondral bone is involved in both symptomatic and structural progression in OA.
Afsie Sabokbar, Allahdad Zarei, M. Kassim Javaid, Philippa A. Hulley   +3 more
core   +2 more sources

Identification and Mechanisms of Osteocyte Subsets Involved in the Pathological Progression of Osteoporosis

Advanced Science, Volume 13, Issue 5, 27 January 2026.
Osteocyte heterogeneity in bone remains poorly understood. This study identifies six distinct osteocyte subsets in mice, revealing a key subpopulation (BHR‐Ocys) that drives bone loss in osteoporosis. BHR‐Ocys promote osteoclast‐mediated resorption via a novel Sema5a‐Plxna1 signaling axis.
Zengxin Jiang, Biyu Rui, Xuecheng He, Jiajun Wang, Xiangdong Wu, Rui Shao, Xue Meng, Xiaochun Peng, Hengfeng Yuan   +8 more
wiley   +1 more source

PTHrP-Derived Peptides Restore Bone Mass and Strength in Diabetic Mice: Additive Effect of Mechanical Loading [PDF]

, 2016
There is an unmet need to understand the mechanisms underlying skeletal deterioration in diabetes mellitus (DM) and to develop therapeutic approaches to treat bone fragility in diabetic patients.
Allen, Matthew R., Bellido, Teresita, Brown, Drew M., Esbrit, Pedro, Gortazar, Arancha R., Maycas, Marta, McAndrews, Kevin A., Pellegrini, Gretel G., Plotkin, Lilian I., Sato, Amy Y.   +9 more
core   +1 more source