Epilepsia, EarlyView.Abstract Objective Accumulating evidence indicates that aberrant C1q‐C3 complement signaling in microglia and astrocytes drives synaptic dysfunction and neuronal loss. C1q‐mediated synaptic dysfunction disrupts neuronal circuitry balance and can lead to network hyperexcitability in epilepsy.
Yoonyi Jeong +5 more
wiley +1 more source
Aerospace medicine and biology: A continuing bibliography with indexes (supplement 361) [PDF]
This bibliography lists 141 reports, articles and other documents introduced into the NASA Scientific and Technical Information System during Mar. 1992.
core +1 more source
Is sleep affected after microgravity and hypergravity exposure? A pilot study
Journal of Sleep Research, Volume 34, Issue 2, April 2025.Summary Sleep is known to be affected in space travel and in residents of the international space station. But little is known about the direct effects of gravity changes on sleep, if other factors, such as sleep conditions, are kept constant. Here, as a first exploration, we investigated sleep before and after exposure to short bouts of microgravity ...
Barbara Le Roy +9 more
wiley +1 more source
Combination inhaled steroid and long-acting beta2-agonist versus tiotropium for chronic obstructive pulmonary disease [PDF]
, 2010 Background Combination therapy (inhaled corticosteroids and long-acting beta(2)-agonists) and tiotropium are both used in the treatment of chronic obstructive pulmonary disease (COPD).
Appleton +20 more
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Attenuation of neurological deficit by a novel ethanolamine derivative in rats after brain trauma
Journal of Experimental Pharmacology, 2019 Yuriy Igorevich Sysoev,1,2 Bright Chukwunwike Uzuegbunam,1 Sergey Vladimirovich Okovityi11Department of Pharmacology and Clinical Pharmacology, Saint-Petersburg State Chemical-Pharmaceutical University, St. Petersburg, Russia; 2Institute of Translational
Sysoev YI, Uzuegbunam BC, Okovityi SV
doaj
Stereochemical studies on protonated bridgehead amines. ^1H NMR determination of cis and trans B-C ring-fused structures for salts of hexahydropyrrolo [2,1-a] isoquinolines and related C ring homologs. Capture of unstable ring-fused structures in the solid state [PDF]
, 1989 Acid-addition salts of tricyclic isoquinolines 2a/b, 3a/b, 4a-4c, 5, 6a/b, 7, 8a/b, 9a/b, and 17a/b were studied by high-field ^1H NMR in CDCl_3 solution.
Inners, Ruth R. +6 more
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Plant Biotechnology Journal, EarlyView.ABSTRACT Efficient purification remains a key technical challenge affecting the recovery efficiency of recombinant proteins in plant‐based systems. Complex metabolites, particularly polyphenols, often cause recombinant protein aggregation during purification.
Hai‐Ping Diao +7 more
wiley +1 more source
Pharmacological manipulation of L-carnitine transport into L6 cells with stable overexpression of human OCTN2 [PDF]
, 2018 .: The high-affinity Na+-dependent carnitine transporter OCTN2 (SLC22A5) has a high renal expression and reabsorbs most filtered carnitine. To gain more insight into substrate specificity of OCTN2, we overexpressed hOCTN2 in L6 cells and characterized ...
Brooks, H. +6 more
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RSC AdvancesMany plants are reported to enhance cognition in amnesic-animal models. The metabolite profile of Cordia dichotoma fruit methanolic extract (CDFME) was characterized by LC-QTOF-MS/MS, and its total phenolics content (TPC) and total flavonoids content ...
Hagar M. Hussein +9 more
semanticscholar +1 more source
Role of Endoscopic Ultrasound‐guided Gastroenterostomy for Benign Gastric Outlet Obstruction
DEN Open, Volume 6, Issue 1, April 2026.ABSTRACT Benign gastric outlet obstruction (GOO) often results from intrinsic conditions like peptic strictures, caustic‐induced stricture, and surgical anastomoses, and extrinsic conditions like pancreatitis, hematoma, and superior mesenteric artery syndrome.
Suprabhat Giri +8 more
wiley +1 more source