Results 91 to 100 of about 9,314 (214)

Neurotoxicity [PDF]

open access: yes, 2014
Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the ...
Brust   +15 more
core   +2 more sources

Impact of Sequential Ramucirumab Plus Docetaxel After PD‐1 Inhibitors on Anti‐PD‐1 Antibody‐Bound T‐Cell Dynamics and Clinical Outcomes

open access: yesCancer Science, Volume 117, Issue 4, Page 929-942, April 2026.
Ramucirumab (RAM) plus docetaxel (DOC) after PD‐1 inhibitors showed clinical activity, with responders exhibiting maintained anti–PD‐1 (IgG4+)‐bound CD8+ T cells and decreased IgG4+ Tregs. A sequential strategy of administering RAM plus DOC during persistent anti–PD‐1 antibody binding may be beneficial in patients with advanced non‐small cell lung ...
Kinnosuke Matsumoto   +20 more
wiley   +1 more source

A Review of the Scale and Sustainability of the Consumption and Trade of Anuran Species in Africa

open access: yesEcology and Evolution, Volume 16, Issue 3, March 2026.
ABSTRACT Within Africa, collection and trade of anurans is often recorded as single‐site case studies, making it difficult to accurately understand the scale of use, its livelihood importance, and impact on species. We conducted a systematic review to: compile literature on anuran uses in Africa; identify the species and ecoregions involved; and ...
Sandra Owusu‐Gyamfi   +5 more
wiley   +1 more source

Ximenia americana L. From Popular Use to Anti‐Inflammatory Activities: A Comprehensive Review

open access: yesFood Frontiers, Volume 7, Issue 2, March 2026.
ABSTRACT Ximenia americana (L.), known as “yellow plum,” “sea lemon,” or “Brazilian plum,” is a tropical/subtropical plant widely used in traditional medicine. Its roots, leaves, flowers, stem, and fruits are traditionally employed to treat various inflammatory disorders.
Bruno Anderson F. Silva   +9 more
wiley   +1 more source

Fighting the global pest problem: Preface to the special Toxicon issue on insecticidal toxins and their potential for insect pest control [PDF]

open access: yes, 2007
Arthropod pests are responsible for major crop devastation and are vectors for the transmission of new and re-emerging diseases in humans and livestock.
Nicholson, GM
core   +1 more source

The Scorpion Toxin Analogue BmKTX-D33H as a Potential Kv1.3 Channel-Selective Immunomodulator for Autoimmune Diseases

open access: yesToxins, 2016
The Kv1.3 channel-acting scorpion toxins usually adopt the conserved anti-parallel β-sheet domain as the binding interface, but it remains challenging to discover some highly selective Kv1.3 channel-acting toxins.
Fang Ye   +7 more
doaj   +1 more source

Role of Antimicrobial Peptides in the Pathogenesis of Atopic Dermatitis

open access: yesThe Journal of Dermatology, Volume 53, Issue 3, Page 372-379, March 2026.
ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by barrier dysfunction, immune dysregulation, and microbial dysbiosis. Recent studies have highlighted the multifaceted roles of antimicrobial peptides (AMPs) both as innate defenders against microbial invasion and as regulators of immune responses and skin barrier ...
Ge Peng   +9 more
wiley   +1 more source

Environmental adaptation and functional diversity of calcin peptides from the venom of East Asian scorpions

open access: yesEcotoxicology and Environmental Safety
Toxins as naturally occurring hazardous substances, have evolved as a defense mechanism in organisms for survival. The expression of toxins is profoundly influenced by environmental factors, and the investigation of their correlation holds significant ...
Xiaoyu Hua   +16 more
doaj   +1 more source

Scorpion Toxins Specific for Potassium (K+) Channels: A Historical Overview of Peptide Bioengineering

open access: yesToxins, 2012
Scorpion toxins have been central to the investigation and understanding of the physiological role of potassium (K+) channels and their expansive function in membrane biophysics.
Zachary L. Bergeron, Jon-Paul Bingham
doaj   +1 more source

Friends or Foes? Emerging Impacts of Biological Toxins [PDF]

open access: yes, 2019
Toxins are substances produced from biological sources (e.g., animal, plants, microorganisms) that have deleterious effects on a living organism. Despite the obvious health concerns of being exposed to toxins, they are having substantial positive impacts
Casewell, N.R.   +6 more
core   +6 more sources

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