Results 71 to 80 of about 5,580 (197)

Consensus sequences and comparison with other α KTx scorpion toxins.

, 2015
(A) Amino acid sequence of reduced and S-alkylated Kbot21 Cysteine residues were identified as PTH-S-pyridylethylcysteine. (B) Sequence comparison of α KTx different scorpion toxins K+ channel inhibitors.
Najet Srairi-Abid (798860), Houcemeddine Othman (798859), Mohamed ElAyeb (798861), Rym ElFessi-Magouri (798857), Jan Tytgat (686707), Riadh Kharrat (798862), Steve Peigneur (798858)   +6 more
core   +1 more source

Conkazal‐M1 from the MKAVA family of conotoxins: A dual‐function protease inhibitor and neuroactive peptide

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Marine cone snails produce a diverse array of bioactive peptides, known as conotoxins, in their venom. Given their high target potency and specificity, conotoxins are attractive compounds for the development of precision research tools and pharmacological agents.
Celeste M. Hackney, Thomas Lund Koch, Nicklas Lund Ryding, Aymeric Rogalski, Kevin Chase, Matías Leonel Giglio, Samuel S. Espino, Zildjian G. Acyatan, Maren Watkins, Baldomero M. Olivera, Helena Safavi‐Hemami, Kaare Teilum, Lars Ellgaard   +12 more
wiley   +1 more source

Schematic diagram of the evolution of scorpion potassium channel toxins.

, 2013
Three putative ancestors were recruited from scorpion proteins to generate diverse potassium channel toxins from five different subfamilies (α-KTxs, β-KTxs, γ-KTxs, κ-KTxs, and δ-KTxs) with three different structural folds (CSα/β, CSα/β, and Kunitz-type).
Jing Feng (177843), Zhijian Cao (316956), Fan Luo (398044), Weishan Yang (393442), Zongyun Chen (340078), Maili Liu (197522), Wenxin Li (9207), Yingliang Wu (45928), Ling Jiang (172296), Danyun Zeng (398045), Ruiming Zhao (340075)   +10 more
core   +1 more source

The Scorpion Toxin Analogue BmKTX-D33H as a Potential Kv1.3 Channel-Selective Immunomodulator for Autoimmune Diseases

Toxins, 2016
The Kv1.3 channel-acting scorpion toxins usually adopt the conserved anti-parallel β-sheet domain as the binding interface, but it remains challenging to discover some highly selective Kv1.3 channel-acting toxins.
Fang Ye, Youtian Hu, Weiwei Yu, Zili Xie, Jun Hu, Zhijian Cao, Wenxin Li, Yingliang Wu   +7 more
doaj   +1 more source

Advancements and Applications of 3D Printing Techniques and Novel Materials in Soft Robotics for Medical Devices

Rare Metals, Volume 45, Issue 5, May 2026.
ABSTRACT Additive manufacturing, commonly referred to as three‐dimensional (3D) printing, provides the geometric freedom and multi‐material integration needed to build soft medical robots for minimally invasive interventions, prosthetics, and rehabilitation.
Yao Wang, Wen Cui, Hongjie Huang, Yuer Yang, Xinyang He, Mingxian Liu   +5 more
wiley   +1 more source

Impact of Comorbidities on Clinical Outcomes and Quality of Life of Patients With Hormone Receptor‐Positive/Human Epidermal Growth Factor Receptor 2‐Negative (HR+/HER2−) Advanced Breast Cancer Treated With Palbociclib in the POLARIS Study

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Background Comorbidities, common in patients with advanced breast cancer (ABC), may impact survival outcomes and health‐related quality of life (HRQoL). Here, we report subgroup analyses on the basis of comorbidities of patients from POLARIS (NCT03280303), a prospective, observational study of patients with hormone receptor‐positive/human ...
Debu Tripathy, Joanne L. Blum, Meghan S. Karuturi, Steven McCune, Sobha Kurian, Mehdi M. Moezi, Daniel M. Anderson, Yan Ji, Timothy J. Pluard, John Migas, Shailendra Lakhanpal, Erin Jepsen, Yao Wang, Monica Z. Montelongo, Zhe Zhang, Joseph C. Cappelleri, Eric Gauthier, Gabrielle B. Rocque   +17 more
wiley   +1 more source

Primary structure of scorpion anti-insect toxins isolated from the venom of Leiurus quinquestriatus quinquestriatus

, 1990
The amino acid sequences of insect-selective scorpion toxins, purified from the venom of Leiurus quinquestriatus quinquestriatus, have been determined by automatic phenyl isothiocyanate degradation of the S-carboxymethylated proteins and derived ...
Charles Kopeyan, Hervé Rochat, Thérèse Brando, Rochat, Hervé, François Sampieri, Brando, Thérèse, El Mostafa Bahraoui, Claude Granier, Kopeyan, Charles, Granier, Claude, Sampieri, François, Pascal Mansuelle, Mostafa Bahraoui, El, Mansuelle, Pascal   +13 more
core   +1 more source

Environmental adaptation and functional diversity of calcin peptides from the venom of East Asian scorpions

Ecotoxicology and Environmental Safety
Toxins as naturally occurring hazardous substances, have evolved as a defense mechanism in organisms for survival. The expression of toxins is profoundly influenced by environmental factors, and the investigation of their correlation holds significant ...
Xiaoyu Hua, Zhixiao Yang, Li Xiao, Songyu Gao, Fengling Yang, Bilin Tao, Yi Wang, Jianguo Wang, Carmen R. Valdivia, Wei Chen, Wengeng Jiang, He Sun, Diguyan Wu, Marina Pozzolini, Lingxin Chen, Héctor H. Valdivia, Liang Xiao   +16 more
doaj   +1 more source

Dysphagia as the Sole Presentation of Lateral Medullary Syndrome in an Octagerian: A Diagnostic Challenge

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Lateral medullary syndrome (LMS) or Wallenberg's syndrome is usually caused by a cerebrovascular accident of the vertebral artery or the posterior inferior cerebellar artery (PICA), leading to damage to the dorsolateral aspects of the medulla oblongata.
Abera Kuma, Bereket A. Tegene, Sosena Sheleme, Shamil Nuri, Abdulkerim Girma, Sinetibeb Tadesse Amsalu   +5 more
wiley   +1 more source

Computational analysis of evolutionary divergence of scorpion toxins

, 2003
51-58Conserved and consensus sequences of several members of scorpion toxin families have been analyzed. Multiple sequence alignment define the highly conserved residues that play important structural role in formation of toxin sub-groups.
Upadhyay, R K
core