Results 61 to 70 of about 4,835 (174)

The Scorpion Toxin Analogue BmKTX-D33H as a Potential Kv1.3 Channel-Selective Immunomodulator for Autoimmune Diseases

Toxins, 2016
The Kv1.3 channel-acting scorpion toxins usually adopt the conserved anti-parallel β-sheet domain as the binding interface, but it remains challenging to discover some highly selective Kv1.3 channel-acting toxins.
Fang Ye, Youtian Hu, Weiwei Yu, Zili Xie, Jun Hu, Zhijian Cao, Wenxin Li, Yingliang Wu   +7 more
doaj   +1 more source

Immune Checkpoint Inhibitors in Cancer Therapy: Clinical Landscape, Resistance Mechanisms, and Therapeutic Innovations

MedComm – Oncology, Volume 5, Issue 3, September 2026.
The up‐to‐date clinical progress of immune checkpoint inhibitor (ICI) therapy in solid tumors, specifically the combinational regimens between ICIs and other treatment strategies, the mechanisms underlying primary and acquired resistance, and mechanism‐matched strategies to improve clinical outcomes are synthesized in this review.
Qiongyu Zhang, Zhi Qin, Caijuan Guo
wiley   +1 more source

First Assessment of Genetic Damage in the Speckled Cockroach (Nauphoeta cinerea) After Consumption of Lettuce (Lactuca sativa) Cultivated and Commercialized in Northeastern, Brazil

Environmental Toxicology, Volume 41, Issue 9, Page 682-689, September 2026.
ABSTRACT This study reports, for the first time, the use of the speckled cockroach Nauphoeta cinerea as a promising bioindicator for genotoxic monitoring. It was validated through control groups (both positive and negative) in addition to testing lettuce (Lactuca sativa ) samples from public street markets consumed by N. cinerea specimens in Pernambuco,
Aleson Aparecido da Silva, Eduardo Henrique da Silva Melo, Érima Maria de Amorim, Maria Gislaine Pereira, Claudia Rohde   +4 more
wiley   +1 more source

Environmental adaptation and functional diversity of calcin peptides from the venom of East Asian scorpions

Ecotoxicology and Environmental Safety
Toxins as naturally occurring hazardous substances, have evolved as a defense mechanism in organisms for survival. The expression of toxins is profoundly influenced by environmental factors, and the investigation of their correlation holds significant ...
Xiaoyu Hua, Zhixiao Yang, Li Xiao, Songyu Gao, Fengling Yang, Bilin Tao, Yi Wang, Jianguo Wang, Carmen R. Valdivia, Wei Chen, Wengeng Jiang, He Sun, Diguyan Wu, Marina Pozzolini, Lingxin Chen, Héctor H. Valdivia, Liang Xiao   +16 more
doaj   +1 more source

Scorpion Toxins Specific for Potassium (K+) Channels: A Historical Overview of Peptide Bioengineering

Toxins, 2012
Scorpion toxins have been central to the investigation and understanding of the physiological role of potassium (K+) channels and their expansive function in membrane biophysics.
Zachary L. Bergeron, Jon-Paul Bingham
doaj   +1 more source

Occurrence of Food Chemical Contaminants in Entomophagy: Implications for Food Safety and Future Risk Assessment—A Scoping Review

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 5, September 2026.
ABSTRACT Entomophagy is increasingly recognized as a sustainable alternative to conventional protein sources due to its low environmental impact. However, ensuring its safety requires careful evaluation of chemical contaminants of food safety concern.
Marta Esgalhado, Dayanne da Costa Maynard, Ariana Saraiva, Marjhory Gonçalves Moura, Didem Aybike Haspolat, José Costa, José Manuel Lorenzo, Zsuzsa Farkas, António Raposo, Maria do Céu Costa   +9 more
wiley   +1 more source

Characterization of a Family of Scorpion Toxins Modulating Ca²⁺-Activated Cl^- Current in Vascular Myocytes. [PDF]

Toxins (Basel), 2022
Morel JL, Mokrzycki N, Lippens G, Drobecq H, Sautière P, Hugues M.   +5 more
europepmc   +1 more source

Venomics of Scorpion Ananteris platnicki (Lourenço, 1993), a New World Buthid That Inhabits Costa Rica and Panama

Toxins
Ananteris is a scorpion genus that inhabits dry and seasonal areas of South and Central America. It is located in a distinctive morpho-group of Buthids, the ‘Ananteris group’, which also includes species distributed in the Old World.
Cecilia Díaz, Bruno Lomonte, Arturo Chang-Castillo, Fabián Bonilla, Adriana Alfaro-Chinchilla, Felipe Triana, Diego Angulo, Julián Fernández, Mahmood Sasa   +8 more
doaj   +1 more source

Global transcriptome analysis of the scorpion Centruroides noxius: new toxin families and evolutionary insights from an ancestral scorpion species.

PLoS ONE, 2012
Scorpion venoms have been studied for decades, leading to the identification of hundreds of different toxins with medical and pharmacological implications.
Martha Rendón-Anaya, Luis Delaye, Lourival D Possani, Alfredo Herrera-Estrella   +3 more
doaj   +1 more source

Study of Anti-Inflammatory and Analgesic Activity of Scorpion Toxins DKK-SP1/2 from Scorpion Buthus martensii Karsch (BmK). [PDF]

Toxins (Basel), 2021
Liu Y, Li Y, Zhu Y, Zhang L, Ji J, Gui M, Li C, Song Y.   +7 more
europepmc   +1 more source