Results 41 to 50 of about 4,656 (172)

Structural and Functional Elucidation of Peptide Ts11 Shows Evidence of a Novel Subfamily of Scorpion Venom Toxins

Toxins, 2016
To date, several families of peptide toxins specifically interacting with ion channels in scorpion venom have been described. One of these families comprise peptide toxins (called KTxs), known to modulate potassium channels.
Caroline M. Cremonez, Mohitosh Maiti, Steve Peigneur, Juliana Silva Cassoli, Alexandre A. A. Dutra, Etienne Waelkens, Eveline Lescrinier, Piet Herdewijn, Maria Elena de Lima, Adriano M. C. Pimenta, Eliane C. Arantes, Jan Tytgat   +11 more
doaj   +1 more source

Vobramitamab duocarmazine, an anti–B7‐H3 antibody–drug conjugate, in patients with advanced solid tumors: Final results of a phase 1 cohort expansion

Cancer, Volume 132, Issue 15, 1 August 2026.
Abstract Background Vobramitamab duocarmazine is an investigational antibody–drug conjugate (ADC) targeting B7 homolog 3 (B7‐H3) with a cytotoxic duocarmycin‐based DNA‐alkylating payload. This study evaluated its safety and antitumor activity in advanced solid tumors.
Eugene Shenderov, Manish R. Sharma, Elena Garralda, John Powderly, Iwona Ługowska, Alexander Spira, Marc Cucurull Salamero, Sekwon Jang, Rasha Cosman, John Shen, Wen Xu, Piotr J. Wysocki, Rodryg Ramlau, Emmanuel S. Antonarakis, Andrew J. Weickhardt, Jakub Żołnierek, Emiliano Calvo, Enxu Zhao, Chet Bohac, Ashley Ward, Girish Mallesara   +20 more
wiley   +1 more source

[Scorpion toxins and defensins].

Comptes rendus des seances de la Societe de biologie et de ses filiales, 1998
Les venins de scorpion contiennent un grand nombre de neurotoxines peptidiques qui constituent un ensemble de familles molécu­laires à haut degré de polymorphisme, mais qui ont en commun une architecture semblable. Cette architecture se retrouve dans des peptides antibactériens circulants de la famille des défensines, qui s'apparentent tout ...
Goyffon, M, Landon, C.
openaire   +2 more sources

The scorpion toxin and the potassium channel

eLife, 2013
The structure of a complex containing a toxin bound to a potassium ion channel has been solved for the first time, revealing how scorpions have designed toxins that can recognize and target the filter that controls the movement of potassium ions through these channels.
openaire   +3 more sources

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, Volume 40, Issue 8, Page 4759-4791, August 2026.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Characterization of Four Medically Important Toxins from Centruroides huichol Scorpion Venom and Its Neutralization by a Single Recombinant Antibody Fragment

Toxins, 2022
Centruroides huichol scorpion venom is lethal to mammals. Analysis of the venom allowed the characterization of four lethal toxins named Chui2, Chui3, Chui4, and Chui5.
Hugo Valencia-Martínez, Timoteo Olamendi-Portugal, Rita Restano-Cassulini, Hugo Serrano-Posada, Fernando Zamudio, Lourival D. Possani, Lidia Riaño-Umbarila, Baltazar Becerril   +7 more
doaj   +1 more source

She Doesn't Whisper: Female‐Prominent Stridulation Shaped by Morphology in a Buthid Scorpion and Insights on Its Function

Ethology, Volume 132, Issue 8, Page 533-543, August 2026.
Sexual dimorphism and stress‐induced stridulatory responses in Jaguajir rochae (Borelli, 1910). Females exhibited greater absolute pectinal size and higher sound pressure levels, whereas males showed higher pectinal allometric ratios relative to body size, lower sound frequencies, and shorter delta times.
Welton Dionisio‐da‐Silva, Natália Maria Câmara Luna, Patrício Adriano da Rocha, Rodrigo Hirata Willemart, Marcio Bernardino daSilva   +4 more
wiley   +1 more source

Bioactivity Assessment and In Silico Target Engagement of Clerodendrum infortunatum Extracts: Correlating Experimental Outcomes With DFT and Docking Predictions

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Clerodendrum infortunatum (Lamiaceae) is widely used in traditional medicine across South and Southeast Asia for the treatment of inflammation, fever, pain, and gastrointestinal disorders, yet its pharmacological efficacy and phytochemical basis remain inadequately validated by scientific research.
Mohi Uddin, Sabikun Naher, Md. Hossain Rasel, Md. Jahirul Islam Mamun, Md. Nazmul Hasan, Nazmul Hasan Eshaque, Md. Mahmudul Hasan   +6 more
wiley   +1 more source

Scorpion venom allergies. Report of three cases. [PDF]

Batna Journal of Medical Sciences
Scorpion envenomations are widespread in many countries around the world. In Algeria, Androctonus australis hector (Aah) and Buthus occitanus tunetanus (Bot) are the cause of the greatest number of envenomations by scorpions and are responsible for ...
Abdelhak ABABSA MOUAKI, Ismahan OUNISSI, Fatima Zohra OUALALOU, Youcef LAALAYMIA, Mohammed Ridha GUEDJATI   +4 more
doaj   +1 more source

Integration of phylogenomics and molecular modeling reveals lineage-specific diversification of toxins in scorpions [PDF]

PeerJ, 2018
Scorpions have evolved a variety of toxins with a plethora of biological targets, but characterizing their evolution has been limited by the lack of a comprehensive phylogenetic hypothesis of scorpion relationships grounded in modern, genome-scale ...
Carlos E. Santibáñez-López, Ricardo Kriebel, Jesús A. Ballesteros, Nathaniel Rush, Zachary Witter, John Williams, Daniel A. Janies, Prashant P. Sharma   +7 more
doaj   +2 more sources