Results 21 to 30 of about 9,314 (214)

Oral Acute Toxicity and Genotoxicity of Heteroctenus junceus Scorpion Venom. [PDF]

Vet Med Sci
The Heteroctenus junceus scorpion venom is a very popular natural extract used in traditional medicine in Cuba. In clinically relevant experimental settings, scorpion venom does not induce general toxicity or an increase in the frequency of micronucleus formation in erythrocytes.
Díaz-García A, Ruiz-Fuentes JL, Mejias Medina S, Zapata Guajardo N, Ross Skarneo C.   +4 more
europepmc   +2 more sources

Optimizing Scorpion Toxin Processing through Artificial Intelligence

Toxins
Scorpion toxins are relatively short cyclic peptides (
Adam Psenicnik, Andres A. Ojanguren-Affilastro, Matthew R. Graham, Mohamed K. Hassan, Mohamed A. Abdel-Rahman, Prashant P. Sharma, Carlos E. Santibáñez-López   +6 more
doaj   +4 more sources

Analysis of the Proteome and Biochemistry of Venom from Tityus confluens, a Scorpion That Can Be Involved in Severe Envenomation Cases in Brazil [PDF]

Toxins
In Brazil, the annual scorpion sting cases surpass those of other neglected tropical diseases, highlighting a significant public health issue. The severity of scorpion envenomation relates to the venom’s rapid action, complex composition, species ...
Laís Corrêa Lima, Henrique Ranieri Covali-Pontes, Ohanna Gabriely Souza Leite, Renata Trentin Perdomo, Luiz Filipe Ramalho Nunes de Moraes, Ludovico Migliolo, Mauricio Nogueira Moyses, Natália Gabrielly Pereira dos Santos, Daniel Carvalho Pimenta, Mariana Soares Rodrigues, Karen Morais-Zani, Guilherme Rabelo Coelho, Malson Neilson Lucena   +12 more
doaj   +2 more sources

Autonomic effects of some scorpion venoms and toxins [PDF]

Clinical and Experimental Pharmacology and Physiology, 2002
Summary1. The autonomic effects of venoms and toxins from several species of scorpions, including the Indian red scorpion Mesobuthus tamulus, the Chinese scorpion Buthus martensi Karsch and the Israeli scorpion Leiurus quinquestriatus quinquestriatus, all belonging to Buthidae, and the Asian black scorpions Heterometrus longimanus and Heterometrus ...
Gwee, MC, Nirthanan, S, Khoo, HE, Gopalakrishnakone, P, Kini, RM, Cheah, LS   +5 more
openaire   +5 more sources

Scorpion Toxins and Ion Channels: Potential Applications in Cancer Therapy. [PDF]

Toxins (Basel), 2020
Dueñas-Cuellar RA, Santana CJC, Magalhães ACM, Pires OR, Fontes W, Castro MS.   +5 more
europepmc   +2 more sources

Transcriptome analysis of Mesobuthus martensii revealed the differences of their toxins between females and males

The European Zoological Journal, 2022
Scorpion venom plays an important role in scorpion predation, competition, communication, and defense. In this study, the species identification of Shandong scorpion and the analysis of venom extracted from male and female scorpion at the transcriptome ...
Y. Yang, Y. Zhu, Y. Luo, Q. Liu, X. Hua, J. Li, F. Gao, J. Hofer, X. Gao, L. Xiao, X. Song, S. Gao, R. Hao   +12 more
doaj   +1 more source

Genomic and structural characterization of Kunitz-type peptide LmKTT-1a highlights diversity and evolution of scorpion potassium channel toxins. [PDF]

PLoS ONE, 2013
BACKGROUND: Recently, a new subfamily of long-chain toxins with a Kunitz-type fold was found in scorpion venom glands. Functionally, these toxins inhibit protease activity and block potassium channels.
Zongyun Chen, Fan Luo, Jing Feng, Weishan Yang, Danyun Zeng, Ruiming Zhao, Zhijian Cao, Maili Liu, Wenxin Li, Ling Jiang, Yingliang Wu   +10 more
doaj   +1 more source

First‐Line Osimertinib in Patients with EGFR‐Mutant Advanced Non‐Small Cell Lung Cancer: Outcome and Safety in the Real World: FLOWER Study

The Oncologist, EarlyView., 2021
Abstract Lessons Learned Osimertinib has confirmed effectiveness in this real‐world population of patients with EGFR‐mutant advanced non‐small cell lung cancer. Thromboembolic events occur more frequently than previously reported, suggesting a thrombotic diathesis that requires further investigation. Patients with at least three metastatic sites, brain
Martina Lorenzi, Alessandra Ferro, Fabiana Cecere, Daniela Scattolin, Alessandro Del Conte, Alessandro Follador, Sara Pilotto, Valentina Polo, Mariacarmela Santarpia, Rita Chiari, Alberto Pavan, Alessandro Dal Maso, Valentina Da Ros, Giada Targato, Sabrina Vari, Stefano Indraccolo, Fiorella Calabrese, Stefano Frega, Laura Bonanno, Pier Franco Conte, Valentina Guarneri, Giulia Pasello   +21 more
wiley   +1 more source

Biochemical and Proteomic Characterization, and Pharmacological Insights of Indian Red Scorpion Venom Toxins

Frontiers in Pharmacology, 2021
The Indian red scorpion (Mesobuthus tamulus) is one of the world’s deadliest scorpions, with stings representing a life-threatening medical emergency. This species is distributed throughout the Indian sub-continent, including eastern Pakistan, eastern ...
Bhabana Das, Anthony J. Saviola, Ashis K. Mukherjee, Ashis K. Mukherjee   +3 more
doaj   +1 more source

Characterization of Kbot21 Reveals Novel Side Chain Interactions of Scorpion Toxins Inhibiting Voltage-Gated Potassium Channels. [PDF]

PLoS ONE, 2015
Scorpion toxins are important pharmacological tools for probing the physiological roles of ion channels which are involved in many physiological processes and as such have significant therapeutic potential.
Rym ElFessi-Magouri, Steve Peigneur, Houcemeddine Othman, Najet Srairi-Abid, Mohamed ElAyeb, Jan Tytgat, Riadh Kharrat   +6 more
doaj   +1 more source