Scorpion Venom: Detriments and Benefits
Biomedicines, 2020 Scorpion venom may cause severe medical complications and untimely death if injected into the human body. Neurotoxins are the main components of scorpion venom that are known to be responsible for the pathological manifestations of envenoming.
Shirin Ahmadi +8 more
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Dramatic expansion of the black widow toxin arsenal uncovered by multi-tissue transcriptomics and venom proteomics. [PDF]
, 2014 BackgroundAnimal venoms attract enormous interest given their potential for pharmacological discovery and understanding the evolution of natural chemistries.
Ayoub, Nadia A +4 more
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Life, 2023 Morocco is known to harbor two of the world’s most dangerous scorpion species: the black Androctonus mauritanicus (Am) and the yellow Buthus occitanus (Bo), responsible for 83% and 14% of severe envenomation cases, respectively.
Ines Hilal +7 more
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The envenomation of general physiology throughout the last century. [PDF]
, 2017 Toxins are the poisonous products of organisms. Toxins serve vital defensive and offensive functions for those that harbor them: stinging scorpions, pesticidal plants, sanguinary snakes, fearless frogs, sliming snails, noxious newts, and smarting spiders.
Sack, Jon T
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Subtype Specificity of β-Toxin Tf1a from Tityus fasciolatus in Voltage Gated Sodium Channels
Toxins, 2018 Scorpion venoms are a complex mixture of components. Among them the most important are peptides, which presents the capacity to interact and modulate several ion channel subtypes, including voltage-gated sodium channels (NaV).
Daniel Oliveira da Mata +6 more
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Genomic organization of the KTX2 gene, encoding a `short' scorpion toxin active on K+ channels [PDF]
, 1997 A single intron of 87 bp, close to the region encoding the C-terminal part of the signal peptide, was found in the gene of the `short' scorpion toxin kaliotoxin 2 of Androctonus australis acting on various types of K+ channels.
Legros, Christian +2 more
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The scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 opening [PDF]
, 2015 We identified Tf2, the first β-scorpion toxin from the venom of the Brazilian scorpion Tityus fasciolatus. Tf2 is identical to Tb2-II found in Tityus bahiensis.We found that Tf2 selectively activates human (h)Nav1.3, a neuronal voltage-gated sodium (Nav)
Bosmans, Frank +4 more
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Neurotransmitter evaluation in the hippocampus of rats after intracerebral injection of TsTX scorpion toxin [PDF]
, 2009 TsTX is an a-type sodium channel toxin that stimulates the discharge of neurotransmitters from neurons. In the present study we investigated which neurotransmitters are released in the hippocampus after TsTX injection and if they are responsible for ...
BARRETO, S. A +5 more
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Spider neurotoxins targeting voltage-gated sodium channels [PDF]
, 2005 The voltage-gated sodium (Nav) channel is a target for a number of drugs, insecticides, and neurotoxins. These bind to at least seven identified neurotoxin binding sites and either block conductance or modulate sodium channel gating and/or kinetics.
Little, MJ, Nicholson, GM
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Bounded Coordinate-Descent for Biological Sequence Classification in High Dimensional Predictor Space [PDF]
, 2010 We present a framework for discriminative sequence classification where the learner works directly in the high dimensional predictor space of all subsequences in the training set.
Ifrim, Georgiana, Wiuf, Carsten
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