Results 31 to 40 of about 5,580 (197)

Turning a Scorpion Toxin into an Antitumor Miniprotein [PDF]

Journal of the American Chemical Society, 2008
The oncoproteins MDM2 and MDMX negatively regulate the activity and stability of the tumor suppressor protein p53 and are important molecular targets for anticancer therapy. Grafting four residues of p53 critical for MDM2/MDMX binding to the N-terminal alpha-helix of BmBKTx1, a scorpion toxin isolated from the venom of the Asian scorpion Buthus ...
Chong, Li, Min, Liu, Juahdi, Monbo, Guozhang, Zou, Changqing, Li, Weirong, Yuan, Davide, Zella, Wei-Yue, Lu, Wuyuan, Lu   +8 more
openaire   +2 more sources

A Combinational Strategy upon RNA Sequencing and Peptidomics Unravels a Set of Novel Toxin Peptides in Scorpion Mesobuthus martensii

Toxins, 2016
Scorpion venom is deemed to contain many toxic peptides as an important source of natural compounds. Out of the two hundred proteins identified in Mesobuthus martensii (M. martensii), only a few peptide toxins have been found so far.
Ning Luan, Wang Shen, Jie Liu, Bo Wen, Zhilong Lin, Shilong Yang, Ren Lai, Siqi Liu, Mingqiang Rong   +8 more
doaj   +1 more source

Terrestrial venomous animals, the envenomings they cause, and treatment perspectives in the Middle East and North Africa.

PLoS Neglected Tropical Diseases, 2021
The Middle East and Northern Africa, collectively known as the MENA region, are inhabited by a plethora of venomous animals that cause up to 420,000 bites and stings each year. To understand the resultant health burden and the key variables affecting it,
Timothy P Jenkins, Shirin Ahmadi, Matyas A Bittenbinder, Trenton K Stewart, Dilber E Akgun, Melissa Hale, Nafiseh N Nasrabadi, Darian S Wolff, Freek J Vonk, Jeroen Kool, Andreas H Laustsen   +10 more
doaj   +1 more source

Characterization of a Novel BmαTX47 Toxin Modulating Sodium Channels: The Crucial Role of Expression Vectors in Toxin Pharmacological Activity

Toxins, 2014
Long-chain scorpion toxins with four disulfide bridges exhibit various pharmacological features towards the different voltage-gated sodium channel subtypes. However, the toxin production still remains a huge challenge.
Tian Li, Lingna Xu, Honglian Liu, Yawen He, Songping Liang, Wenxin Li, Yingliang Wu   +6 more
doaj   +1 more source

Chaperone-mediated native folding of a β-scorpion toxin in the periplasm of E.coli

, 2014
Background: Animal neurotoxin peptides are valuable probes for investigating ion channel structure/function relationships and represent lead compounds for novel therapeutics and insecticides.
Cole, Ambrose R., Lampert, A., Wallace, Bonnie A., O'Reilly, A.O., O’Reilly, A.O., Wallace, B.A., Cole, A.R., Lopes, J.L.S.   +7 more
core   +1 more source

Exploring the Inter- and Intra-Specific Variability of Androctonus Scorpion Venoms

Biology and Life Sciences Forum, 2023
Scorpion venom possesses a lethal sting and potential medicinal properties, making it a captivating natural elixir. Our study aimed to unravel the composition of Androctonus scorpionvenoms in Morocco.
Ines Hilal, Soukaina Khourcha, Amal Safi, Abdelaziz Hmyene, Reto Stöcklin, Naoual Oukkache   +5 more
doaj   +1 more source

Biotechnological Trends in Spider and Scorpion Antivenom Development

Toxins, 2016
Spiders and scorpions are notorious for their fearful dispositions and their ability to inject venom into prey and predators, causing symptoms such as necrosis, paralysis, and excruciating pain.
Andreas Hougaard Laustsen, Mireia Solà, Emma Christine Jappe, Saioa Oscoz, Line Præst Lauridsen, Mikael Engmark   +5 more
doaj   +1 more source

Venoms of Iranian Scorpions (Arachnida, Scorpiones) and Their Potential for Drug Discovery

Molecules, 2019
Scorpions, a characteristic group of arthropods, are among the earliest diverging arachnids, dating back almost 440 million years. One of the many interesting aspects of scorpions is that they have venom arsenals for capturing prey and defending against ...
Seyed Mahdi Kazemi, Jean-Marc Sabatier
doaj   +1 more source

Isolation and characterization of CvIV4: a pain inducing α-scorpion toxin. [PDF]

PLoS ONE, 2011
Among scorpion species, the Buthidae produce the most deadly and painful venoms. However, little is known regarding the venom components that cause pain and their mechanism of action. Using a paw-licking assay (Mus musculus), this study compared the pain-
Ashlee H Rowe, Yucheng Xiao, Joseph Scales, Klaus D Linse, Matthew P Rowe, Theodore R Cummins, Harold H Zakon   +6 more
doaj   +1 more source

Limb Compression Therapy and Chemotherapy‐Induced Peripheral Neuropathy in Women With Gynecologic Cancers: A Prospective Self‐Controlled Study(NEURO‐GLOVE Trial)

International Journal of Cancer, EarlyView.
With no effective drug‐based prevention strategies available for chemotherapy‐induced peripheral neuropathy (CIPN), research in neuroprotective approaches has grown. Of particular interest is mechanical compression, which may protect nerves by temporarily reducing blood flow during treatment. The authors here conducted a prospective trial in women with
Kadriye Başkurt, Galip Can Uyar, Enes Yeşilbaş, Fatma Zehra Altunç, Damla Erimhan Çevik, İsmet Murat Melek, Yasemin Eren, Ömür Berna Çakmak Öksüzoğlu, Kadriye Bir Yücel, Antonio Di Meglio, Isabelle Ray‐Coquard, Osman Sütcüoğlu   +11 more
wiley   +1 more source