Results 11 to 20 of about 5,580 (197)
Genomic and structural characterization of Kunitz-type peptide LmKTT-1a highlights diversity and evolution of scorpion potassium channel toxins. [PDF]
PLoS ONE, 2013 BACKGROUND: Recently, a new subfamily of long-chain toxins with a Kunitz-type fold was found in scorpion venom glands. Functionally, these toxins inhibit protease activity and block potassium channels.
Zongyun Chen +10 more
doaj +2 more sources
Frontiers in Pharmacology, 2021 The Indian red scorpion (Mesobuthus tamulus) is one of the world’s deadliest scorpions, with stings representing a life-threatening medical emergency. This species is distributed throughout the Indian sub-continent, including eastern Pakistan, eastern ...
Bhabana Das +3 more
doaj +2 more sources
Characterization of Kbot21 Reveals Novel Side Chain Interactions of Scorpion Toxins Inhibiting Voltage-Gated Potassium Channels. [PDF]
PLoS ONE, 2015 Scorpion toxins are important pharmacological tools for probing the physiological roles of ion channels which are involved in many physiological processes and as such have significant therapeutic potential.
Rym ElFessi-Magouri +6 more
doaj +2 more sources
Scorpion toxins specific for Na+‐channels [PDF]
European Journal of Biochemistry, 1999 Na+‐channel specific scorpion toxins are peptides of 60–76 amino acid residues in length, tightly bound by four disulfide bridges. The complete amino acid sequence of 85 distinct peptides are presently known. For some toxins, the three‐dimensional structure has been solved by X‐ray diffraction and NMR spectroscopy.
Possani, Lourival D. +3 more
openaire +4 more sources
Optimizing Scorpion Toxin Processing through Artificial Intelligence
ToxinsScorpion toxins are relatively short cyclic peptides (
Adam Psenicnik +6 more
doaj +2 more sources
Scorpion Venom: Detriments and Benefits
Biomedicines, 2020 Scorpion venom may cause severe medical complications and untimely death if injected into the human body. Neurotoxins are the main components of scorpion venom that are known to be responsible for the pathological manifestations of envenoming.
Shirin Ahmadi +8 more
doaj +2 more sources
Toxins, 2012 Scorpion toxins have been central to the investigation and understanding of the physiological role of potassium (K+) channels and their expansive function in membrane biophysics.
Zachary L. Bergeron, Jon-Paul Bingham
doaj +2 more sources
Toxins, 2020 The Hemiscorpius lepturus scorpion and brown spider Loxosceles intermedia represent a public health problem in Asia and America, respectively. Although distinct, these organisms contain similar toxins responsible for the principal clinical signs of ...
Ramla Ben Yekhlef +9 more
doaj +2 more sources
Autonomic effects of some scorpion venoms and toxins [PDF]
Clinical and Experimental Pharmacology and Physiology, 2002 Summary1. The autonomic effects of venoms and toxins from several species of scorpions, including the Indian red scorpion Mesobuthus tamulus, the Chinese scorpion Buthus martensi Karsch and the Israeli scorpion Leiurus quinquestriatus quinquestriatus, all belonging to Buthidae, and the Asian black scorpions Heterometrus longimanus and Heterometrus ...
Selvanayagam Nirthanan +2 more
exaly +4 more sources
Analysis of the Proteome and Biochemistry of Venom from Tityus confluens, a Scorpion That Can Be Involved in Severe Envenomation Cases in Brazil [PDF]
ToxinsIn Brazil, the annual scorpion sting cases surpass those of other neglected tropical diseases, highlighting a significant public health issue. The severity of scorpion envenomation relates to the venom’s rapid action, complex composition, species ...
Laís Corrêa Lima +12 more
doaj +2 more sources