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The insecticidal potential of scorpion β-toxins
Toxicon, 2007Voltage-gated sodium channels are a major target for toxins and insecticides due to their central role in excitability, but due to the conservation of these channels in Animalia most insecticides do not distinguish between those of insects and mammals, thereby imposing risks to humans and livestock.
Gurevitz, M. +9 more
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Autonomic Effects of Some Scorpion Venoms and Toxins [PDF]
Clinical and Experimental Pharmacology and Physiology, 2002 Summary1. The autonomic effects of venoms and toxins from several species of scorpions, including the Indian red scorpion Mesobuthus tamulus, the Chinese scorpion Buthus martensi Karsch and the Israeli scorpion Leiurus quinquestriatus quinquestriatus, all belonging to Buthidae, and the Asian black scorpions Heterometrus longimanus and Heterometrus ...
Selvanayagam Nirthanan +2 more
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Interactions of Scorpion Toxins with the Sodium Channel
Annals of the New York Academy of Sciences, 1986It is evident from the data reviewed that scorpion toxins can be distinguished on the basis of three properties: their effects on Na currents, their specific binding to excitable membranes, and the effects of depolarization and pH on binding and on effect.
H, Meves, J M, Simard, D D, Watt
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Scorpion toxins prefer salt solutions
Journal of Molecular Modeling, 2015There is a wide variety of ion channel types with various types of blockers, making research in this field very complicated. To reduce this complexity, it is essential to study ion channels and their blockers independently. Scorpion toxins, a major class of blockers, are charged short peptides with high affinities for potassium channels.
Azadeh, Nikouee +2 more
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1997
Abstract α-Toxins can be considered as the cause of the scorpion venom toxicity for mammals and particularly human beings, in the ‘Old World’ (Miranda et al. 1970). For example, 90 per cent of the toxicity for the mouse in the venom of Androctonus australis from North Africa is due to only 2 per cent of the weight of the crude venom. The
M -F Martin-Eauclaire, P E Bougis
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Abstract α-Toxins can be considered as the cause of the scorpion venom toxicity for mammals and particularly human beings, in the ‘Old World’ (Miranda et al. 1970). For example, 90 per cent of the toxicity for the mouse in the venom of Androctonus australis from North Africa is due to only 2 per cent of the weight of the crude venom. The
M -F Martin-Eauclaire, P E Bougis
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Conformational variations amongst scorpion toxins
Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1986Circular dichroism spectra were obtained for ten scorpion neurotoxins (representing five species of scorpion) in order to provide an understanding of their relative conformations in solution. Despite a high degree of amino acid sequence homology, the toxins clearly differ from each other in terms of CD-detectable structure.
M J, Dufton, A F, Drake, H, Rochat
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Adaptive Evolution of Scorpion Sodium Channel Toxins
Journal of Molecular Evolution, 2004Gene duplication followed by positive Darwinian selection is an important evolutionary event at the molecular level, by which a gene can gain new functions. Such an event might have occurred in the evolution of scorpion sodium channel toxin genes (alpha- and beta-groups).
Zhu, Shunyi, Bosmans, Frank, Tytgat, Jan
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[The rational evolution of scorpion toxins].
Bioorganicheskaia khimiia, 1997A theoretical method for the rational design of a "universal" scorpion toxin with a wider spectrum of specificity for K+ channels and a more stable alpha/beta-folding than in its natural homologues is described. On the basis of the analysis of molecular hydrophobic potentials (MHP) of the protein spatial structures, structural features for a family of ...
Zharavin , V.A. +2 more
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Tityus serrulatus Scorpion Venom and Toxins: An Overview
Protein & Peptide Letters, 2009Tityus serrulatus is considered the most dangerous scorpion in South America and responsible for most of the fatal cases. This review will focus on Tityus serrulatus scorpion venom (Tsv), its long-chain Na(+)-channel toxins (NaTx), which include alpha- and beta-neurotoxins, short-chain K(+)-channel toxins (KTx), hyaluronidase, proteases and other ...
Cologna, Camila T. +4 more
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