Results 31 to 40 of about 16,145 (220)

Transmission of scrapie prions to primate after an extended silent incubation period

Scientific Reports, 2015
Classical bovine spongiform encephalopathy (c-BSE) is the only animal prion disease reputed to be zoonotic, causing variant Creutzfeldt-Jakob disease (vCJD) in humans and having guided protective measures for animal and human health against animal prion ...
E. Comoy, J. Mikol, Sophie Luccantoni-Freire, E. Correia, Nathalie Lescoutra-etchegaray, V. Durand, C. Dehen, O. Andréoletti, C. Casalone, J. Richt, J. Greenlee, T. Baron, S. Benestad, P. Brown, J. Deslys   +14 more
semanticscholar   +1 more source

Scrapie prevalence in sheep of susceptible genotype is declining in a population subject to breeding for resistance

BMC Veterinary Research, 2010
Background Susceptibility of sheep to scrapie infection is known to be modulated by the PrP genotype of the animal. In the Netherlands an ambitious scrapie control programme was started in 1998, based on genetic selection of animals for breeding.
Engel Bas, Davidse Aart, Bossers Alex, Melchior Marielle B, Hagenaars Thomas J, van Zijderveld Fred G   +5 more
doaj   +1 more source

Scrapie versus Chronic Wasting Disease in White-Tailed Deer

Emerging Infectious Diseases
White-tailed deer are susceptible to scrapie (WTD scrapie) after oronasal inoculation with the classical scrapie agent from sheep. Deer affected by WTD scrapie are difficult to differentiate from deer infected with chronic wasting disease (CWD).
Zoe J. Lambert, Jifeng Bian, Eric D. Cassmann, M. Heather West Greenlee, Justin J. Greenlee   +4 more
doaj   +1 more source

Transmissibility of atypical scrapie in ovine transgenic mice: major effects of host prion protein expression and donor prion genotype. [PDF]

PLoS ONE, 2009
Atypical scrapie or Nor98 has been identified as a transmissible spongiform encephalopathy (TSE) that is clearly distinguishable from classical scrapie and BSE, notably regarding the biochemical features of the protease-resistant prion protein PrP(res ...
Jean-Noël Arsac, Dominique Bétemps, Eric Morignat, Cécile Féraudet, Anna Bencsik, Denise Aubert, Jacques Grassi, Thierry Baron   +7 more
doaj   +1 more source

The placenta shed from goats with classical scrapie is infectious to goat kids and lambs

Journal of General Virology, 2015
The placenta of domestic sheep plays a key role in horizontal transmission of classical scrapie. Domestic goats are frequently raised with sheep and are susceptible to classical scrapie, yet potential routes of transmission from goats to sheep are not ...
D. Schneider, Sally A. Madsen-Bouterse, D. Zhuang, T. Truscott, R. Dassanayake, K. O'Rourke   +5 more
semanticscholar   +1 more source

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source

Histopathological studies of "CH1641-like" scrapie sources versus classical scrapie and BSE transmitted to ovine transgenic mice (TgOvPrP4).

PLoS ONE, 2011
The possibility of the agent causing bovine spongiform encephalopathy (BSE) infecting small ruminants is of serious concern for human health. Among scrapie cases, the CH1641 source in particular appears to have certain biochemical properties similar to ...
Anna Bencsik, Thierry Baron
doaj   +1 more source

Disease phenotype of classical sheep scrapie is changed upon experimental passage through white-tailed deer.

PLoS Pathogens, 2023
Prion agents occur in strains that are encoded by the structure of the misfolded prion protein (PrPSc). Prion strains can influence disease phenotype and the potential for interspecies transmission.
Robyn D Kokemuller, S Jo Moore, Jifeng Bian, M Heather West Greenlee, Justin J Greenlee   +4 more
doaj   +1 more source

Infection Risk From Humans and Animals in the Anatomy Laboratory: A Scoping Review

Clinical Anatomy, Volume 39, Issue 3, Page 346-367, April 2026.
ABSTRACT Whole‐body dissection is a cornerstone of anatomy education. During and following the COVID‐19 pandemic, exposure to infectious agents and other risks of dissection were highlighted. To identify potential risks, one must have the data outlining these risks in specific situations.
Margaret A. McNulty, Elizabeth R. Agosto
wiley   +1 more source

Evidence of scrapie transmission via milk

BMC Veterinary Research, 2008
Background The risk of scrapie infection increases with increased duration and proximity of contact between sheep at lambing. Scrapie infectivity has not been detected in milk but cellular prion protein, the precursor of disease-associated prion protein ...
Moore S Jo, Konold Timm, Bellworthy Susan J, Simmons Hugh A   +3 more
doaj   +1 more source