Results 81 to 90 of about 81,661 (282)

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Exploring the single-cell RNA-seq analysis landscape with the scRNA-tools database.

PLoS Computational Biology, 2018
As single-cell RNA-sequencing (scRNA-seq) datasets have become more widespread the number of tools designed to analyse these data has dramatically increased.
Luke Zappia, Belinda Phipson, Alicia Oshlack   +2 more
doaj   +1 more source

An accessible, interactive GenePattern Notebook for analysis and exploration of single-cell transcriptomic data [version 2; peer review: 2 approved]

F1000Research, 2019
Single-cell RNA sequencing (scRNA-seq) has emerged as a popular method to profile gene expression at the resolution of individual cells. While there have been methods and software specifically developed to analyze scRNA-seq data, they are most accessible
Clarence K. Mah, Alexander T. Wenzel, Edwin F. Juarez, Thorin Tabor, Michael M. Reich, Jill P. Mesirov   +5 more
doaj   +1 more source

Bayesian gamma-negative binomial modeling of single-cell RNA sequencing data

BMC Genomics, 2020
Background Single-cell RNA sequencing (scRNA-seq) is a powerful profiling technique at the single-cell resolution. Appropriate analysis of scRNA-seq data can characterize molecular heterogeneity and shed light into the underlying cellular process to ...
Siamak Zamani Dadaneh, Paul de Figueiredo, Sing-Hoi Sze, Mingyuan Zhou, Xiaoning Qian   +4 more
doaj   +1 more source

The molecular landscape of neurological disorders: insights from single-cell RNA sequencing in neurology and neurosurgery

European Journal of Medical Research, 2023
Single-cell ribonucleic acid sequencing (scRNA-seq) has emerged as a transformative technology in neurological and neurosurgical research, revolutionising our comprehension of complex neurological disorders.
Wireko Andrew Awuah, Arjun Ahluwalia, Shankaneel Ghosh, Sakshi Roy, Joecelyn Kirani Tan, Favour Tope Adebusoye, Tomas Ferreira, Hareesha Rishab Bharadwaj, Vallabh Shet, Mrinmoy Kundu, Amanda Leong Weng Yee, Toufik Abdul-Rahman, Oday Atallah   +12 more
doaj   +1 more source

Predicting lung aging using scRNA-Seq data

PLOS Computational Biology
Age prediction based on single cell RNA-Sequencing data (scRNA-Seq) can provide information for patients’ susceptibility to various diseases and conditions. In addition, such analysis can be used to identify aging related genes and pathways. To enable age prediction based on scRNA-Seq data, we developed PolyEN, a new regression model which learns ...
Song, Qi, Singh, Alex, Mcdonough, John E., Adams, Taylor S., Vos, Robin, De Man, Ruben, Myers, Greg, Ceulemans, Laurens J., Vanaudenaerde, Bart M., Wuyts, Wim A., Yan, Xiting, Schuppe, Jonas, Hagood, James S., Kaminski, Naftali, Bar-Joseph, Ziv   +14 more
openaire   +3 more sources

Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis Care &Research, EarlyView.
Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla, Robert Lafyatis, Kevin F. Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J. Kass   +13 more
wiley   +1 more source

SCALE method for single-cell ATAC-seq analysis via latent feature extraction. [PDF]

, 2019
Single-cell ATAC-seq (scATAC-seq) profiles the chromatin accessibility landscape at single cell level, thus revealing cell-to-cell variability in gene regulation.
Gao, Ge, Jiang, Tao, Shao, Yanqiu, Tang, Lei, Tian, Kang, Xiong, Lei, Xu, Kui, Zhang, Michael, Zhang, Qiangfeng Cliff   +8 more
core  

Interfacial Bioengineering of Dynamic Networks Hybrid Hydrogel for Programmed Intervention in Oral Precancerous Epithelial States

Advanced Healthcare Materials, EarlyView.
This study develops a dual‐bioinspired hydrogel, MSA@PGel (macrophage membrane‐coated and salvianolic acid B/5‐aminolevulinic acid co‐loaded liposomes embedded in a polydopamine‐based gel), that integrates macrophage membrane‐mediated active targeting and mussel‐inspired wet adhesion for programmed intervention in oral precancerous lesions.
Xiaoxian Zhao, Ao Zheng, Zhengyan Zhao, Qilin Li, Tianhao Wan, Tanjun Deng, Ying Zhang, Lingyan Cao, Lan Wu   +8 more
wiley   +1 more source

Kidney Organoids in Drug Development: Integrating Technological Advances and Standardization for Effective Implementation

Advanced Healthcare Materials, EarlyView.
This review examines how emerging enabling technologies enhance the physiological relevance, scalability, and reproducibility of kidney organoids, while advanced analytical approaches support model validation and deepen mechanistic insight into nephrotoxicity.
Helen Kearney, Silvia M. Mihăilă, Lorenzo Moroni, Carlos Mota   +3 more
wiley   +1 more source