Results 51 to 60 of about 3,764 (237)

Seasonal Malaria Chemoprevention Coverage Survey Guinea, 2017 [PDF]

, 2018
Loua, K, Milligan, P
core   +2 more sources

Efficacy and safety of primaquine and methylene blue for prevention of Plasmodium falciparum transmission in Mali: a phase 2, single-blind, randomised controlled trial. [PDF]

, 2018
BACKGROUND: Primaquine and methylene blue are gametocytocidal compounds that could prevent Plasmodium falciparum transmission to mosquitoes. We aimed to assess the efficacy and safety of primaquine and methylene blue in preventing human to mosquito ...
Bousema, Teun, Bradley, John, Brown, Joelle M, Chen, Ingrid, Diarra, Kalifa, Diawara, Halimatou, Dicko, Alassane, Drakeley, Chris, Gosling, Roly, Hwang, Jimee, Issiaka, Djibrilla, Keita, Sekouba, Kone, Daouda T, Lanke, Kjerstin, Mahamar, Almahamoudou, McCulloch, Charles, Müller, Olaf, Roh, Michelle E, Sanogo, Koualy, Soumare, Harouna M, Srinivasan, Vinay, Stone, Will JR, Traore, Sekou F   +22 more
core   +2 more sources

Analysis of Preventive Interventions for Malaria: Exploring Partial and Complete Protection and Total and Primary Intervention Effects. [PDF]

, 2015
Event dependence, the phenomenon in which future risk depends on past disease history, is not commonly accounted for in the statistical models used by malaria researchers. However, recently developed methods for the analysis of repeated events allow this
Asante, Kwaku Poku, Cairns, Matthew, Chandramohan, Daniel, Cheung, Yin Bun, Diallo, Diadier, Dicko, Alassane, Greenwood, Brian, Konate, Amadou T, Milligan, Paul, Owusu-Agyei, Seth, Xu, Ying   +10 more
core   +2 more sources

Evaluation of seasonal malaria chemoprevention implementation in the Upper East region of Northern Ghana. [PDF]

Malar J
Ghana adopted the WHO-recommended Seasonal Malaria Chemoprevention (SMC) in 2016 following a pilot study as a vital strategy for malaria control. SMC is the intermittent administration of a preventive and curative dose of anti-malarial medicine (Sulfadoxine-Pyrimetamine + Amodiaquine) during four months of the malaria season.
Ayamba EY, Dzotsi EK, Dormechele W, Ansah NA, Bangre O, Nyuzaghl JA, Abilba SA, Boakye-Boateng SK, Ansah PO.   +8 more
europepmc   +4 more sources

Intermittent preventive treatment with dihydroartemisinin-piperaquine in Ugandan schoolchildren selects for Plasmodium falciparum transporter polymorphisms that modify drug sensitivity. [PDF]

, 2016
Dihydroartemisinin-piperaquine (DP) offers prolonged protection against malaria, but its impact on Plasmodium falciparum drug sensitivity is uncertain. In a trial of intermittent preventive treatment in schoolchildren in Tororo, Uganda, in 2011 to 2012 ...
Brooker, SJ, Conrad, MD, Dorsey, G, Kamya, MR, Legac, J, Nankabirwa, JI, Nsobya, SL, Rosenthal, PJ, Staedke, SG, Tukwasibwe, S, Tumwebaze, P, Wandera, B   +11 more
core   +3 more sources

Seasonal malaria vaccination: protocol of a phase 3 trial of seasonal vaccination with the RTS,S/AS01_Evaccine, seasonal malaria chemoprevention and the combination of vaccination and chemoprevention

BMJ Open, 2020
IntroductionSeasonal malaria chemoprevention (SMC), with sulphadoxine–pyrimethamine plus amodiaquine (SP+AQ) is effective but does not provide complete protection against clinical malaria. The RTS,S/AS01Emalaria vaccine provides a high level of protection shortly after vaccination, but this wanes rapidly.
Ismaila Thera, Irene Kuepfer, Daniel Chandramohan, Alassane Dicko, Issaka Zongo, Issaka Sagara, Matthew Cairns, Modibo Diarra, Amadou Tapily, Djibrilla Issiaka, Koualy Sanogo, Almahamoudou Mahamar, Frederic Sompougdou, Serge Yerbanga, Paul Milligan, Halidou Tinto, Opokua Ofori-Anyinam, Jean-Bosco Ouedraogo, B Greenwood   +18 more
openaire   +3 more sources

Effect of Seasonal Malaria Chemoprevention on Immune Markers of Exhaustion and Regulation [PDF]

The Journal of Infectious Diseases, 2019
Abstract Background Seasonal malaria chemoprevention (SMC) is a novel strategy to reduce malaria infections in children. Infection with Plasmodium falciparum results in immune dysfunction characterized by elevated expression of markers associated with exhaustion, such as PD1 and LAG3, and regulatory ...
Oumar, Attaher, Irfan, Zaidi, Jennifer L, Kwan, Djibrilla, Issiaka, Mamoudou B, Samassekou, Kadidia B, Cisse, Barou, Coulibaly, Sekouba, Keita, Sibiri, Sissoko, Tiangoua, Traore, Kalifa, Diarra, Bacary S, Diarra, Adama, Dembele, Moussa B, Kanoute, Almahamoudou, Mahamar, Amadou, Barry, Michal, Fried, Alassane, Dicko, Patrick E, Duffy   +18 more
openaire   +2 more sources

Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda. [PDF]

, 2017
BackgroundPlasmodium falciparum genetic polymorphisms that mediate altered drug sensitivity may impact upon virulence. In a cross-sectional study, Ugandan children with infections mutant at pfcrt K76T, pfmdr1 N86Y, or pfmdr1 D1246Y had about one-fourth ...
Arinaitwe, Emmanuel, Conrad, Melissa, Dorsey, Grant, Greenhouse, Bryan, Kamya, Moses R, Nsobya, Samuel L, Rosenthal, Philip J, Tukwasibwe, Stephen, Tumwebaze, Patrick   +8 more
core   +1 more source

A Randomized Trial to Compare the Safety, Tolerability, and Effectiveness of 3 Antimalarial Regimens for the Prevention of Malaria in Nigerian Patients With Sickle Cell Disease. [PDF]

, 2015
BACKGROUND: Malaria prophylaxis is recommended for persons with sickle cell disease (SCD), but the value of this has been questioned. The aim of this study was to find out whether intermittent preventive treatment (IPT) with a fixed-dose combination of ...
Affara, Muna, Bello, Surajudeen, Bojang, Kalifa, Ernest, Kolade, Greenwood, Brian, Ibrahim, Olayinka, Kiechel, Jean-René, Lambe, Tosin, Milligan, Paul, Mokuolu, Olugbenga, Murtala, Rukayat, Nwakanma, Davis, Ogunkunle, Taofik, Ojuawo, Ayotade, Olagunju, Tope, Olaosebikan, Rasaq, Olorunsola, Benedict, Omefe, Peter, Rehman, Andrea M   +18 more
core   +2 more sources

Mass campaigns combining antimalarial drugs and anti-infective vaccines as seasonal interventions for malaria control, elimination and prevention of resurgence: a modelling study

BMC Infectious Diseases, 2019
Background The only licensed malaria vaccine, RTS,S/AS01, has been developed for morbidity-control in young children. The potential impact on transmission of deploying such anti-infective vaccines to wider age ranges, possibly with co-administration of ...
Flavia Camponovo, Chris F. Ockenhouse, Cynthia Lee, Melissa A. Penny   +3 more
doaj   +1 more source