A Randomized Trial to Compare the Safety, Tolerability, and Effectiveness of 3 Antimalarial Regimens for the Prevention of Malaria in Nigerian Patients With Sickle Cell Disease. [PDF]
, 2015 BACKGROUND: Malaria prophylaxis is recommended for persons with sickle cell disease (SCD), but the value of this has been questioned. The aim of this study was to find out whether intermittent preventive treatment (IPT) with a fixed-dose combination of ...
Affara, Muna +18 more
core +2 more sources
BMC Infectious Diseases, 2019 Background The only licensed malaria vaccine, RTS,S/AS01, has been developed for morbidity-control in young children. The potential impact on transmission of deploying such anti-infective vaccines to wider age ranges, possibly with co-administration of ...
Flavia Camponovo +3 more
doaj +1 more source
Seasonal Malaria Chemoprevention Coverage in Guinea in 2019 [PDF]
, 2020 SMC involves the administration of a treatment course of sulfadoxine-pyrimethamine plus amodiaquine once a month to children aged 3 59 months during the high risk period each year to prevent malaria. SMC over 4 months of the year was introduced in Guinea in 2015 in 6 prefectures, scaling up to 13 prefectures by 2018.
Loua, Kovana Marcel, Milligan, Paul
openaire +1 more source
Malaria Journal, 2023 Background Malaria is the leading cause of morbidity and mortality among infants and children under-five in sub-Saharan Africa. In the Sahel, seasonal malaria chemoprevention (SMC) is delivered door-to-door in monthly cycles.
Taiwo Ibinaiye +6 more
doaj +1 more source
Independent origin of plasmodium falciparum antifolate super-resistance, Uganda, Tanzania, and Ethiopia. [PDF]
, 2014 Super-resistant Plasmodium falciparum threatens the effectiveness of sulfadoxine-pyrimethamine in intermittent preventive treatment for malaria during pregnancy. It is characterized by the A581G Pfdhps mutation on a background of the double-mutant Pfdhps
Alifrangis, Michael +15 more
core +3 more sources
Gametocyte carriage after seasonal malaria chemoprevention in Plasmodium falciparum infected asymptomatic children [PDF]
Malaria Journal, 2020 Abstract Background Treatment of clinical Plasmodium falciparum malaria with sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ) is associated with increased post-treatment gametocyte carriage.
Abdullahi Ahmad +10 more
openaire +7 more sources
Entomological impact of indoor residual spraying with pirimiphos-methyl: a pilot study in an area of low malaria transmission in Senegal. [PDF]
, 2018 BACKGROUND: Scaling-up of effective anti-malarial control strategies in Central-West region of Senegal has resulted in the sharp decline in malaria prevalence in this area.
Ba, Elhadji Conco Ciré +10 more
core +2 more sources
Molecular monitoring of Plasmodium falciparum super-resistance to sulfadoxine-pyrimethamine in Tanzania. [PDF]
, 2016 BACKGROUND: Sulfadoxine-pyrimethamine (SP) is recommended for prophylactic treatment of malaria in pregnancy while artemisinin combination therapy is the recommended first-line anti-malarial treatment.
Alifrangis, Michael +8 more
core +4 more sources
Delivery strategies for malaria vaccination in areas with seasonal malaria transmission
BMJ Global Health, 2023 Background Seasonal vaccination with the RTS,S/AS01E malaria vaccine given alongside seasonal malaria chemoprevention (SMC) substantially reduces malaria in young children.
Jayne Webster +9 more
doaj +1 more source
Malaria in school-age children in Africa: an increasingly important challenge. [PDF]
, 2014 School-age children have attracted relatively little attention as a group in need of special measures to protect them against malaria. However, increasing success in lowering the level of malaria transmission in many previously highly endemic areas will ...
Brooker, Simon J +6 more
core +2 more sources