Results 61 to 70 of about 5,985 (143)

Pharmacokinetic considerations in seasonal malaria chemoprevention

Trends in Parasitology, 2022
Los niños africanos menores de 5 años soportan la principal carga de la mortalidad mundial por malaria. La quimioprevención estacional de la malaria (SMC) con sulfadoxina-pirimetamina (SP) más amodiaquina (AQ) administrada mensualmente durante la temporada de lluvias es una intervención altamente efectiva contra la malaria para niños de entre 3 meses y
Chotsiri, P, White, NJ, Tarning, J
openaire   +2 more sources

Interplay among malnutrition, chemoprevention, and the risk of malaria in young Ugandan children: Longitudinal pharmacodynamic and growth analysis

CPT: Pharmacometrics &Systems Pharmacology, Volume 12, Issue 5, Page 656-667, May 2023., 2023
Abstract African children are at risk of malaria and malnutrition. We quantified relationships between malaria and malnutrition among young Ugandan children in a high malaria transmission region. Data were used from a randomized controlled trial where Ugandan HIV‐unexposed (n = 393) and HIV‐exposed (n = 186) children were randomized to receive no ...
Ali Mohamed Ali, Erika Wallender, Emma Hughes, Grant Dorsey, Radojka M. Savic   +4 more
wiley   +1 more source

Seasonal malaria vaccination: protocol of a phase 3 trial of seasonal vaccination with the RTS,S/AS01_Evaccine, seasonal malaria chemoprevention and the combination of vaccination and chemoprevention

BMJ Open, 2020
IntroductionSeasonal malaria chemoprevention (SMC), with sulphadoxine–pyrimethamine plus amodiaquine (SP+AQ) is effective but does not provide complete protection against clinical malaria. The RTS,S/AS01Emalaria vaccine provides a high level of protection shortly after vaccination, but this wanes rapidly.
Daniel Chandramohan, Frederic Sompougdou, Issaka Zongo, Alassane Dicko, Issaka Sagara, Irene Kuepfer, Opokua Ofori-Anyinam, Halidou Tinto, Almahamoudou Mahamar, Serge Yerbanga, Brian Greenwood, Amadou Tapily, Ismaila Thera, Jean-Bosco Ouédraogo, Koualy Sanogo, Matthew Cairns, Paul Milligan, Modibo Diarra, Djibrilla Issiaka   +18 more
openaire   +4 more sources

Evaluation of direct and indirect effects of seasonal malaria chemoprevention in Mali [PDF]

Scientific Reports, 2018
AbstractRandomized controlled trials have established that seasonal malaria chemoprevention (SMC) in children is a promising strategy to reduce malaria transmission in Sahelian West Africa. This strategy was recently introduced in a dozen countries, and about 12 million children received SMC in 2016. However, evidence on SMC effectiveness under routine
Thomas Druetz, Thomas Druetz
openaire   +3 more sources

“We witnessed medicines help our children, then we became proud”: experiences and acceptability of seasonal malaria chemoprevention in Aweil, South Sudan [PDF]

Malar J
Okot F, Sans M, Viganò E, Rom A, Mubiru D, Baker K, Khan J, Julla A.   +7 more
europepmc   +3 more sources

Community Informed Approach for Designing Seasonal Malaria Chemoprevention Delivery in Semi-Nomadic Population in Turkana Central Sub-County, Kenya: Results from Baseline Mixed-Methods Study

medRxiv
N. Kostandova, C. Kafu, T. Chepkwony, G. Ambani, L. Abel, B. Rotich, J. Kipkoech, E. Kimachas, E. Robie, K. Lowoi, D. Ekai, G. Lokoel, O. Orinda, S. Van Hulle, R. Mgeni, W. O'Meara, A. Wesolowski, B. Genberg, D. Menya   +18 more
semanticscholar   +2 more sources

Seasonal Malaria Chemoprevention in Guinea in 2020: coverage survey results [PDF]

, 2021
In 2020 SMC was implemented in 17 out of 33 prefectures, which include 50% of the population outside the city of Conakry. The COVID-19 pandemic, and the presidential elections in Guinea, could potentially have affected SMC campaigns in 2020, it was therefore important to evaluate coverage of SMC given these challenges and the increased area of ...
Loua, Kovana Marcel, Milligan, Paul
openaire   +2 more sources

Effect of Seasonal Malaria Chemoprevention on Immune Markers of Exhaustion and Regulation [PDF]

The Journal of Infectious Diseases, 2019
Abstract Background Seasonal malaria chemoprevention (SMC) is a novel strategy to reduce malaria infections in children. Infection with Plasmodium falciparum results in immune dysfunction characterized by elevated expression of markers associated with exhaustion, such as PD1 and LAG3, and regulatory ...
Patrick E. Duffy, Sekouba Keita, Jennifer Kwan, Adama B. Dembele, Oumar Attaher, Almahamoudou Mahamar, Alassane Dicko, Mamoudou B Samassekou, Michal Fried, Barou Coulibaly, Sibiri Sissoko, Moussa B. Kanoute, Bacary S. Diarra, Djibrilla Issiaka, Amadou Barry, Kadidia B. Cisse, Kalifa Diarra, Tiangoua Traore, Irfan Zaidi   +18 more
openaire   +3 more sources

Sub-national tailoring of seasonal malaria chemoprevention in Mali based on malaria surveillance and rainfall data

Parasites & Vectors, 2022
Abstract Background In malaria endemic countries, seasonal malaria chemoprevention (SMC) interventions are performed during the high malaria transmission in accordance with epidemiological surveillance data. In this study we propose a predictive approach for tailoring the timing and number of cycles of SMC in all health ...
Cissoko, Mady, Sagara, Issaka, Landier, Jordi, Guindo, Abdoulaye, Sanogo, Vincent, Coulibaly, Oumou, Dembélé, Pascal, Dieng, Sokhna, Bationo, Cedric, Diarra, Issa, Magassa, Mahamadou, Berthé, Ibrahima, Katilé, Abdoulaye, Traoré, Diahara, Dessay, Nadine, Gaudart, Jean   +15 more
openaire   +4 more sources

The use of video job-aids to improve the quality of seasonal malaria chemoprevention delivery

PLOS Digital Health, 2022
Mobile phones are increasingly used in community health programmes, but the use of video job-aids that can be displayed on smart phones has not been widely exploited. We investigated the use of video job-aids to support the delivery of seasonal malaria chemoprevention (SMC) in countries in West and Central Africa. The study was prompted by the need for
Susana Scott, Bienvenu Salim Camara, Michael Hill, Eugène Kaman Lama, Lansana Barry, Aurore Ogouyemi-Hounto, William Houndjo, Gauthier Tougri, Nombre Yacouba, Dorothy Achu, Marcellin Ateba, Mahamat Saleh Issakha Diar, Keziah L. Malm, Kofi Adomako, Paolo Djata, Wica Da Silva, Idrissa Cissé, Vincent Sanogo, Hadiza Jackou, Nnenna Ogbulafor, Bala M. Adu, Jamilu Nikau, Seynabou Gaye, Alioune Badara Gueye, Balla Kandeh, Olimatou Kolley, Tinah Atcha-Oubou, Tchassama Tchadjobo, Kovana Marcel Loua, Andre-Marie Tchouatieu, Ibrahima Mbaye, Maria-Angeles Lima-Parra, Abena Poku-Awuku, Jean Louis Ndiaye, Corinne Merle, Liz Thomas, Paul Milligan   +36 more
openaire   +4 more sources