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Second Messenger System in Neoplasia
Oncology, 2009Hormones have been observed to initiate tumors in animals and are thought to be involved in cellular selection and/or progression of neoplastic lesions in humans. Hormones are the ‘First messengers’ in mammalian systems as they allow cell to cell and organ to organ communication A ‘second messenger’ system is currently being elucidated.
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Cyclic AMP second messenger systems
Current Opinion in Cell Biology, 1991Cells carefully regulate the generation and destruction of cAMP using diverse families of adenylate cyclases and phosphodiesterases. Genes for several cyclases have now been cloned, giving structural information about the enzymes and providing access to the remaining members of this family.
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NEW TOOLS FOR THE LOCALIZATION OF SECOND MESSENGER SYSTEMS
Clinical and Experimental Pharmacology and Physiology, 1989SUMMARY1. Probes available for the localization of components of second messenger systems include G‐protein oligonucleotides which have been used to produce cDNA probes to label G‐protein mRNA by in situ hybridization histochemistry.2. Enzymes involved in second messenger responses have been labelled with [3H]‐forskolin (Gs‐linked adenylate cyclase ...
R J, Summers, L R, McMartin
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The second messenger system as the morphogenetic field
Biochemical and Biophysical Research Communications, 1989For sixty years morphogenetic fields have been assumed. We suggest a realization for such a field: the second messenger (in particular cyclic AMP) and its substrate (in particular ATP) are suggested to be the activator-morphogen and inhibitor respectively. Gene transcription is derived as an hysteretic function of the second messenger (cyclic AMP).
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EXTENDED ROLES IN THE BRAIN FOR SECOND-MESSENGER SYSTEMS
Neuroscience, 1977Publisher Summary The term 'second messenger' is of biochemical origin and refers to an intracellular component of linked reaction-sequences by which cells or organs interact with each other. As a second messenger, cyclic AMP also performs several roles in the brain but the scope and coordination of these actions are still in the course of being ...
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Second Messenger Systems in the Brain
1982About 25 years ago, Sutherland and his colleagues made an important discovery. Epinephrine and glucagon, acting as hormones, were both known to be able to profoundly affect the activity of the liver phosphorylase that catalyzes the conversion of glycogen to glucose 1-phosphate. Sutherland and Rail (1958), however, noted that the hormonal stimulation of
Stanislav Reinis, Jerome M. Goldman
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Immunocytochemistry of second messenger systems
Trends in Neurosciences, 1981Abstract The physiological response of a cell to a neurotransmitter is dependent upon a chain of intracellular biochemical events, involving the cyclic nucleotides and Ca 2+ . These ‘second messenger' systems may occur in a variety of neuronal, glial, vascular or connective tissue cell types in the brain.
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Neurotransmitters and Second Messenger Systems in the Carotid Body
1993It is well known that multiple cellular events are regulated by second messenger systems (Greengard and Costa, 1970; Sekar et al., 1986; Hockberger et al., 1987). Among second messengers, cAMP have been shown to modulate several ionic channels and neurotransmitter synthesis and release in different structures (Joh et al.,1978; Hockberger et al., 1987 ...
M T, Pérez-García +3 more
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Regulation of Second Messenger Systems and Intracellular Pathways
2009The A3 adenosine receptor is a G protein-coupled receptor linked to classical second messenger pathways such as those for cAMP production and phospholipase C. In addition, the receptor couples to mitogen-activated protein kinases (MAPK) and to the phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt) pathway which could give it a role in cell ...
MERIGHI, Stefania +3 more
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Calmodulin and Its Role in the Second-Messenger System
1979Publisher Summary This chapter provides an overview of calmodulin and its role in the second-messenger system. Calmodulin is a ubiquitous regulatory protein of the second-messenger system. It exhibits Ca2+-dependent regulatory activities toward several enzymes and proteins.
J H, Wang, D M, Waisman
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