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Mediation of serotonin hyperalgesia by the cAMP second messenger system
Neuroscience, 1992In this study we have evaluated the second messenger system that might couple 5-HT1A receptor activation to produce peripheral hyperalgesia. The intradermal injection of the serotonin (5-hydroxytryptamine; 5-HT) receptor agonist for the 1A receptor subset (5-HT1A), (+/-)-2-dipropylamino-8-hydroxy-1,2,3,4-tetrahydronaphthaline hydrobromide (8-OH DPAT ...
Y O, Taiwo, P H, Heller, J D, Levine
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Differentiation of second messenger systems in mast cell activation
Agents and Actions, 1989Pretreatment of rat peritoneal mast cells with either Staurosporine or an analog K-252a, lead to a dose-related inhibition of histamine release when stimulated with Anti-IgE (IC50: Staurosporine = 110 nM; K-252a = 100 nM). In contrast, the two PKC inhibitors (1-1000 nM) failed to inhibit histamine release induced by compound 48/80 (0.5-1 micrograms/ml).
J R, White, D, Zembryki
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A role for glucocorticoids in the polyphosphoinositide second messenger system
Medical Hypotheses, 1987Glucocorticoids have been shown to be involved in numerous secretory and activation processes which are known to be mediated by the polyphosphoinositide second messenger system. A connection between glucocorticoids and the polyphosphoinositide system has not been made because of the marked temporal differences in their effects and the fact that most of
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Dynamic Interactions of the Second Messenger Systems
1988The response of living cells to changes in cell environment depends on the production and actions of second messenger molecules. The two most extensively studied second messengers are Ca2+ and cAMP, each of which has been demonstrated to regulate unique metabolic reactions and pathways.
Chiayeng Wang +2 more
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Second Messenger Systems and Signal Transduction Mechanisms
1997Hormones are secreted, reach their target, and bind to a receptor. The interaction of the hormone with the receptor produces an initial signal that, through a series of steps, results in the final hormone action. How does the binding of a hormone to a receptor result in a cellular action?
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Astrocytic receptors and second messenger systems
2003Publisher Summary This chapter reviews that glial cells support neuronal activity and create opportunities for the dynamics and plasticity of the central nervous system (CNS). After injury, metabolic disturbance or toxic influence, and in degenerative disease, glial cell reactions protect neurons and facilitate rebuilding. It explores that astrocytes
Elisabeth Hansson∗, Lars Rönnbäck
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Hepoxilins Modulate Second Messenger Systems in the Human Neutrophil
1991In this chapter, we will review recent findings which implicate the hepoxilins as modulators of second messenger systems in the human neutrophil. We have shown that the hepoxilins affect calcium homeostasis in the cell and that they stimulate the release of arachidonic acid and diradylglycerol but not inositol phosphate indicating a mode of action for ...
C R, Pace-Asciak, S, Nigam
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Opioid-Coupled Second Messenger Systems
1988Receptors are normally considered as composed of two separate parts: a specific ligand binding site and an effector component that causes a specific biological response subsequent to agonist binding. Historically, neurotransmitter receptors have been identifed by both properties.
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Targeting the Action of Antidepressant Drugs on Second-Messenger Systems
1996Studies of the function of neuronal systems in depression have shifted in the last years from investigations of neurotransmitter turnover/metabolism and receptor binding to more molecular assessment strategies such as intracellular targets beyond the receptors. G proteins (Lesch et al.
G. Racagni +4 more
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Zebrafish Melanophores: A Model for Teaching Second Messenger Systems
Zebrafish, 2016A strong literature base supports the notion that active learning improves retention in the science classroom. To that end, a course was designed to allow students to develop their own experiments around a central biological question. The model system used in this particular course is control of melanosome dispersal via second messenger systems in ...
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