Results 91 to 100 of about 1,581,172 (300)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Risk of second primary thyroid cancer in cancer survivors

Scientific Reports
A risk factor for thyroid cancer (TC) may be a history of former cancer and cancer therapy. The precise risk of a second primary thyroid carcinoma has not yet been revealed.
Yewei Yuan, Peng Sun, Hualin Xiao, Lingfan Li, Junyan Li, Xiang Ai   +5 more
doaj   +1 more source

Surgery for lung cancer as the second primary malignancy

Acta Medica Lituanica, 2013
Following a successful treatment of the first oncological disease, the second malignancy can develop. This retrospective study was designed to evaluate the efficacy of surgical treatment results for patients with the second primary lung cancer (2PLC ...
Arnoldas Krasauskas, Renatas Aškinis, Sigitas Zaremba, Giedrė Smailytė, Saulius Cicėnas   +4 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Risk of second primary malignancies in women with breast cancer: Results from the European prospective investigation into cancer and nutrition (EPIC) [PDF]

, 2015
Women with a diagnosis of breast cancer are at increased risk of second primary cancers, and the identification of risk factors for the latter may have clinical implications.
Tjonneland, Anne, Chirlaque, Maria-Dolores, Vineis, Paolo, Benetou, Vassiliki, Borgquist, Signe, Weiderpass, Elisabete, Travis, Ruth C., Bueno-De-Mesquita, H. Bas, Khaw, Kay-Tee, Sund, Malin, Clavel-Chapelon, Françoise, Trichopoulou, Antonia, Romieu, Isabelle, Riboli, Elio, Ricceri, Fulvio, Tumino, Rosario, Peeters, Petra H., Gunter, Marc, Adarakis, George, Mattiello, Amalia, Bueno-De-Mesquita, H B As, Butt, Salma, Sacerdote, Carlotta, Sieri, Sabina, Rinaldi, Sabina, Ardanaz, Eva, Andersson, Anne, Giraudo, Maria Teresa, Lund University., Masala, Giovanna, Kaaks, Rudolf, Peeters, Petra H, Olsen, Anja, Skeie, Guri, Chirlaque, María Dolores, Sund, Malin,, Kadi, Mai, Kvaskoff, Marina, Chang-Claude, Jenny, Clavel-Chapelon, Franc Oise, Travier, Noemie, Borgquist, Signe,, Quirós, J Ramón, Overvad, Kim, Khaw, Kay Tee, Sanchez, Maria-Jose, Fasanelli, Francesca, Andersson, Anne,, Travis, Ruth C, Bueno-de-Mesquita, H. B(As), Dossus, Laure, Larranaga, Nerea, Ramon Quiros, J., Quirõs, J. Ramõn, Vagliano, Liliana, Sánchez, María José, Boeing, Heiner   +56 more
core   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Does muscle invasive bladder cancer following pelvic radiotherapy portend worse prognosis? A seer-based study

Cancer Treatment and Research Communications, 2020
Background: Although emerging evidence demonstrates increased risk of secondary bladder cancer following pelvic radiotherapy, the aggressiveness of these tumors is not well-characterized. Materials and Methods: A search of the Surveillance, Epidemiology,
Caleb Natale, Gabriel Leinwand, Farid Zeineddine, Jonathan L Silberstein, Louis S Krane   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source