Results 101 to 110 of about 14,604,770 (257)

Biopsy confirmation of metastatic sites in breast cancer patients:clinical impact and future perspectives [PDF]

, 2014
Determination of hormone receptor (estrogen receptor and progesterone receptor) and human epidermal growth factor receptor 2 status in the primary tumor is clinically relevant to define breast cancer subtypes, clinical outcome, and the choice of therapy.
Carmen Criscitiello, Thompson, Alastair M., Locatelli, Marzia, Curigliano, Giuseppe, Orsi, Franco, F. Orsi, Fabrice André, Criscitiello, Carmen, Minchella, Ida, M. Locatelli, F. André, Thompson, Alastair M, Marzia Locatelli, Giuseppe Curigliano, Curigliano, Guiseppe, Ida Minchella, De Laurentiis, Michele, Lucia Gelao, Luca Fumagalli, Franco Orsi, Esposito, Angela, Goldhirsch, Aron, Angela Esposito, A. M. Thompson, DE LAURENTIIS, MICHELINO, L. Fumagalli, A. Goldhirsch, André, Fabrice, Michele De Laurentiis, Alastair M Thompson, A. Esposito, Fumagalli, Luca, G. Curigliano, M. De Laurentiis, Aron Goldhirsch, C. Criscitiello, L. Gelao, Gelao, Lucia, I. Minchella   +38 more
core   +2 more sources

Synchronous Squamous Cell Carcinoma of the Hypopharynx and Adenocarcinoma of the Lung: A Report of Two Cases Treated with Definitive Radiotherapy

Journal of Radiation and Cancer Research
Head and neck squamous cell carcinoma with second primary lung adenocarcinoma is relatively rare. Because of the rarity of such a clinical scenario, there is no standard guideline on the treatment protocol for such patients. Here, we present two cases of
Jyotiman Nath, Mouchumee Bhattacharyya, Saswati Datta, Shiraj Ahmed, Jahnabi Das, Yanpothung Yanthan   +5 more
doaj   +1 more source

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Cancer Trends: Cancer of the pancreas

, 2012
Cancer of the pancreas accounts for approximately 2.5% of all invasive cancers and is the 9th most commonly diagnosed cancer in Ireland.1 Almost 400 cases of pancreatic cancer were diagnosed annually between 1994 and 2010 (Table 1).
National Cancer Registry Ireland (NCRI)
core  

Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells.

, 2016
Resistance to available hormone therapies in prostate cancer has been associated with alternative splicing of androgen receptor (AR) and specifically, the expression of truncated and constitutively active AR variant 7 (AR-V7).
Yuan, W, Crespo, M, Lyons, JF, Plymate, SR, Ferraldeschi, R, Riisnaes, R, Hedayat, S, Carreira, S, Nava Rodrigues, D, de Bono, JS, Wang, H, Miranda, S, Figueiredo, I, Attard, G, Smyth, T, Welti, J, Powers, MV, Wallis, N, Sharp, S, Seed, G, Workman, P   +20 more
core   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Cancer Trends: Childhood cancer

, 2017
This is the second trends report NCRI has published on childhood cancers, updating a previous report covering 1994-20111. To facilitate summary of the amount and complexity of material included, presentation and layout has been in general retained from ...
National Cancer Registry Ireland (NCRI)
core  

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Young patients with colorectal cancer have increased risk of second primary cancers

, 2017
Objective: Because the number of long-term survivors of colorectal cancer has increased, second primary cancer has become an important issue. However, previous studies were heterogeneous in design, and few data for Asia-Pacific area were available ...
梁逸歆;邵幼雲;賴美淑;林宗哲;鄭安理;葉坤輝;郭年真, Liang, Yi-Hsin;Shao, Yu-Yun;Chen, Ho-Min;Lai, Chiu-Lin;Lin, Zhong-Zhe;Kuo, Raymond Nien-Chen;Cheng, Ann-Lii;Yeh, Kun-Huei;Lai, Mei-Shu   +1 more
core   +1 more source