Results 101 to 110 of about 1,581,172 (300)

Epidemiology and pathophysiology of cancer-associated thrombosis [PDF]

, 2010
Venous thromboembolism (VTE) is a common complication in patients with malignant disease. First recognised by Bouillard in 1823 and later described by Trousseau in 1844, multiple studies have since provided considerable evidence for a clinical ...
Pasi, J, S Noble, J Pasi, Noble, Simon Ian Robert, Pasi, J., Noble, S   +5 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Mortality of lung cancer as a second primary malignancy: A population-based cohort study. [PDF]

, 2019
To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked DownloadLung cancer as a second primary malignancy (lung-2) is increasingly common ...
Deng, L, Loo, BW, Xiao, Zhengrui, Donghao Lu, Billy W. Loo, Unnur Valdimarsdóttir, Zhengrui Xiao, Changchuan Jiang, Haiying Cheng, Deng, Lei, Valdimarsdóttir, Unnur, Hardardottir, H, Song, Huan, Lu, Donghao, Hrönn Harðardottír, Wang, Q, Xiao, Z, Jiang, C, Loo, Billy W, Qian Wang, Valdimarsdottir, U,, Lu, D,, Cheng, Haiying, Loo, Billy W., Song, H, Lei Deng, Cheng, H, Harðardottír, Hrönn, Jiang, Changchuan, Wang, Qian, Huan Song   +30 more
core   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Mode of primary cancer detection as an indicator of screening practice for second primary cancer in cancer survivors: a nationwide survey in Korea. [PDF]

, 2012
BACKGROUND: While knowledge and risk perception have been associated with screening for second primary cancer (SPC), there are no clinically useful indicators to identify who is at risk of not being properly screened for SPC.
박은철
core  

Trends in the epidemiology of larynx and lung cancer in south-east England, 1985-2004. [PDF]

, 2008
We analysed data on 8987 larynx and 174060 lung cancer patients diagnosed between 1985 and 2004, of which 17.3% of larynx and 35.5% of lung cancers were in females.
Davies, E. A.; id_orcid, Moller, H.; id_orcid, Davies, EA, Sehgal, A., H Møller, Chapman, P., Sehgal, A, V H Coupland, Chapman, P, A Sehgal, Møller, H, Coupland, V. H., K M Linklater, Coupland, VH, Linklater, KM, P Chapman, E A Davies, Linklater, K. M.   +17 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Synchronous Squamous Cell Carcinoma of the Hypopharynx and Adenocarcinoma of the Lung: A Report of Two Cases Treated with Definitive Radiotherapy

Journal of Radiation and Cancer Research
Head and neck squamous cell carcinoma with second primary lung adenocarcinoma is relatively rare. Because of the rarity of such a clinical scenario, there is no standard guideline on the treatment protocol for such patients. Here, we present two cases of
Jyotiman Nath, Mouchumee Bhattacharyya, Saswati Datta, Shiraj Ahmed, Jahnabi Das, Yanpothung Yanthan   +5 more
doaj   +1 more source

Impact of BRCA1/2 germline mutation on the incidence of second primary cancer following postoperative radiotherapy in patients with triple-negative breast cancer [PDF]

Zhongguo aizheng zazhi
Background and purpose: BRCA1/2 plays an important role in maintaining the genome stability. Whether BRCA1/2 germline mutation could increase the tumor sensitivity to radiotherapy, thereby inducing secondary primary cancer after radiotherapy is unclear ...
HU Xiaoyu, CAI Yuwen, YE Fugui, SHAO Zhimin, HU Weigang, YU Keda
doaj   +1 more source