Results 81 to 90 of about 1,581,172 (300)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Reliability of recording uterine cancer in death certification in France and age-specific proportions of deaths from cervix and corpus uteri. [PDF]

, 2011
French uterine cancer recordings in death certificates include 60% of "uterine cancer, Not Otherwise Specified (NOS)"; this hampers the estimation of mortalities from cervix and corpus uteri cancers. The aims of this work were to study the reliability of
Velten, Michel, Rogel, Agnès, Buémi, A., Laurence Chérié-Challine, Arveux, Patrick, Chérié-Challine, Laurence, Velten, M., Colonna, Marc, Boussac, Marjorie, Iwaz, J., Remontet, Laurent, Antoine Buémi, Arveux, P., Esteve, J., Florence Suzan, Grosclaude, Pascale, Jacques Estève, Guizard, A-V., Marjorie Boussac, Jean Iwaz, Boussac, M., Laurent Remontet, Aurélien Belot, Ganry, O., Olivier Ganry, Agnès Rogel, Guizard, Anne-Valérie, Chérié-Challine, L., Nadine Bossard, Arlette Danzon, Danzon, A., Jougla, E., Iwaz, Jean, Michel Velten, Patrick Arveux, Marc Colonna, Belot, Aurélien, Estève, Jacques, Jougla, Eric, Ganry, Olivier, Danzon, Arlette, Buémi, Antoine, Eric Jougla, Rogel, A., Colonna, M., Grosclaude, P., Anne-Valérie Guizard, Suzan, Florence, Belot, A., Pascale Grosclaude, Remontet, L., Suzan, F., Bossard, Nadine   +52 more
core   +1 more source

Differential Second Primary Malignancy Occurrence After Breast Cancer According to HER2 Status: A Population-Based Study

International Journal of General Medicine, 2021
Xiaoyi Lin,1,2,* Xin Lin,1,3,* Yingzi Li,1,2,* Yuchen Zhang,1,4 Jiali Lin,1 Guochun Zhang1 1Department of Breast Cancer, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People’s Republic of
Lin X, Lin X, Li Y, Zhang Y, Lin J, Zhang G   +5 more
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Field Cancerisation of the Upper Aerodigestive Tract: Screening for Second Primary Cancers of the Oesophagus in Cancer Survivors [PDF]

, 2015
Tobacco, alcohol, and betel quid are the main causes of squamous cell cancers of the upper aerodigestive tract. These substances can cause multifocal carcinogenesis leading to multiple synchronous or metachronous cancers of the oesophagus, head and neck
Güllü Cataldegirmen, Jan Eick, Christoph Schwertner, Joachim Steinberg, Hermann Herbst3, Wanda Ring   +5 more
core  

The long-term outcomes of metachronous tumors for non-small cell lung cancer

Clinical Surgical Oncology
Background: We aimed to identify prognostic factors for mortality and survival in patients operated on for metachronous primary lung cancer (MPLC).
Celalettin Kocaturk, Cem Emrah Kalafat, Celal Bugra Sezen, Mustafa Vedat Dogru, Levent Cansever, Muzaffer Metin, Mehmet Ali Bedirhan   +6 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Recurrences and second primary breast cancers in older women with initial early-stage disease. [PDF]

, 2009
BACKGROUND: The association between common breast cancer therapies and recurrences and second primary breast cancers in older women is unclear, although older women are less likely to receive common therapies.
Enger, Shelley M., Thwin, Soe Soe, Geiger, Ann M., Buist, Diana S. M., Prout, Marianne N., Field, Terry S., Frost, Floyd J., Yood, Marianne Ulcickas, Wei, Feifei, Lash, Timothy L., Silliman, Rebecca A.   +10 more
core   +1 more source