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γ-Secretase as a Target for Alzheimer’s Disease
2007γ-Secretase is a protease complex responsible for cutting the transmembrane domain of the amyloid β-protein precursor (APP) to form the amyloid β-protein (Aβ), an aggregation-prone product that accumulates in the brain in Alzheimer's disease. As evidence suggests that Aβ is critical to Alzheimer pathogenesis, γ-secretase is considered a key target for ...
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Alpha-Secretase As a Therapeutic Target
Current Alzheimer Research, 2007In the non-amyloidogenic pathway the alpha-secretase cleaves the amyloid precursor protein (APP) within the sequence of Abeta-peptides and precludes their formation. In addition, alpha-secretase cleavage releases an N-terminal extracellular domain with neurotrophic and neuroprotective properties.
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Activation of α‐secretase cleavage
Journal of Neurochemistry, 2011J. Neurochem. (2012) 120 (Suppl. 1), 46–54.AbstractAlpha‐secretase‐mediated cleavage of the amyloid precursor protein (APP) releases the neuroprotective APP fragment sαAPP and prevents amyloid β peptide (Aβ) generation. Moreover, α‐secretase‐like cleavage of the Aβ transporter ‘receptor for advanced glycation end products’ counteracts the import of ...
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Structural basis of γ-secretase inhibition and modulation by small molecule drugs
Cell, 2021Guanghui Yang, Rui Zhou, Xuefei Guo
exaly
The substrate repertoire of γ-secretase/presenilin
Seminars in Cell and Developmental Biology, 2020Gokhan Guner, Stefan F Lichtenthaler
exaly
Alzheimer’s-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions
Cell, 2017Maria Szaruga +2 more
exaly